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Advantages of Anterior Segment Optical Coherence Tomography Evaluation of the Kayser-Fleischer Ring in Wilson Disease.
Cornea 2017; 36(3):343-346C

Abstract

PURPOSE

To present anterior segment optical coherence tomography (AS-OCT) findings of the Kayser-Fleischer (KF) ring in Wilson disease (WD) and to discuss the potential advantages of evaluating the KF ring by AS-OCT.

METHODS

This is a retrospective case series of 7 patients with WD with KF rings seen in our institute during the study period (August 2015 to June 2016). All patients underwent slit-lamp examination of the cornea and AS-OCT (Optovue RTVue Premier). In 2 patients, the length of the KF ring was measured using the gray scale of AS-OCT.

RESULTS

The KF ring on the gray scale of AS-OCT was visualized as a hyperreflective deep corneal layer at the level of Descemet membrane in all eyes. The OCT color scale revealed the KF ring as a greenish, greenish-yellow, yellow, or yellow-orange band. The gray scale of AS-OCT could easily measure the length of the KF ring in patients 6 and 7.

CONCLUSIONS

AS-OCT is an alternative method of evaluating the KF ring in WD, which can be used in combination with slit-lamp examination. The KF ring can be easily measured using the gray scale of AS-OCT. Further studies are required to study the potential advantages of AS-OCT including assessing the density of the KF ring, as a tool to assess response to treatment in WD, in differentiating the KF ring of WD disease from copper deposits in other situations and pigmented corneal rings in non-Wilsonian liver disease.

Authors+Show Affiliations

Department of Ophthalmology, Krishna Institute of Medical Sciences, Hyderabad, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28060027

Citation

Sridhar, Mittanamalli S.. "Advantages of Anterior Segment Optical Coherence Tomography Evaluation of the Kayser-Fleischer Ring in Wilson Disease." Cornea, vol. 36, no. 3, 2017, pp. 343-346.
Sridhar MS. Advantages of Anterior Segment Optical Coherence Tomography Evaluation of the Kayser-Fleischer Ring in Wilson Disease. Cornea. 2017;36(3):343-346.
Sridhar, M. S. (2017). Advantages of Anterior Segment Optical Coherence Tomography Evaluation of the Kayser-Fleischer Ring in Wilson Disease. Cornea, 36(3), pp. 343-346. doi:10.1097/ICO.0000000000001126.
Sridhar MS. Advantages of Anterior Segment Optical Coherence Tomography Evaluation of the Kayser-Fleischer Ring in Wilson Disease. Cornea. 2017;36(3):343-346. PubMed PMID: 28060027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advantages of Anterior Segment Optical Coherence Tomography Evaluation of the Kayser-Fleischer Ring in Wilson Disease. A1 - Sridhar,Mittanamalli S, PY - 2017/1/7/pubmed PY - 2017/8/12/medline PY - 2017/1/7/entrez SP - 343 EP - 346 JF - Cornea JO - Cornea VL - 36 IS - 3 N2 - PURPOSE: To present anterior segment optical coherence tomography (AS-OCT) findings of the Kayser-Fleischer (KF) ring in Wilson disease (WD) and to discuss the potential advantages of evaluating the KF ring by AS-OCT. METHODS: This is a retrospective case series of 7 patients with WD with KF rings seen in our institute during the study period (August 2015 to June 2016). All patients underwent slit-lamp examination of the cornea and AS-OCT (Optovue RTVue Premier). In 2 patients, the length of the KF ring was measured using the gray scale of AS-OCT. RESULTS: The KF ring on the gray scale of AS-OCT was visualized as a hyperreflective deep corneal layer at the level of Descemet membrane in all eyes. The OCT color scale revealed the KF ring as a greenish, greenish-yellow, yellow, or yellow-orange band. The gray scale of AS-OCT could easily measure the length of the KF ring in patients 6 and 7. CONCLUSIONS: AS-OCT is an alternative method of evaluating the KF ring in WD, which can be used in combination with slit-lamp examination. The KF ring can be easily measured using the gray scale of AS-OCT. Further studies are required to study the potential advantages of AS-OCT including assessing the density of the KF ring, as a tool to assess response to treatment in WD, in differentiating the KF ring of WD disease from copper deposits in other situations and pigmented corneal rings in non-Wilsonian liver disease. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/28060027/Advantages_of_Anterior_Segment_Optical_Coherence_Tomography_Evaluation_of_the_Kayser_Fleischer_Ring_in_Wilson_Disease_ L2 - http://Insights.ovid.com/pubmed?pmid=28060027 DB - PRIME DP - Unbound Medicine ER -