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Resting Energy Expenditure in Adults with Becker's Muscular Dystrophy.
PLoS One. 2017; 12(1):e0169848.Plos

Abstract

PURPOSE

The purpose of this study was: 1) To compare Resting energy expenditure (REE) in adult males with Becker's Muscular Dystrophy (BeMD, n = 21, 39 ±12 years) and healthy controls (CTRL, n = 12, 37 ±12 years) 2) Determine whether other physiological parameters correlate with REE in BeMD, and 3) Compare current prediction methods of REE with measured REE.

METHODS

REE was calculated via indirect calorimetry using continuous, expired gas analysis following an overnight fast. Fat free mass (FFM) and fat mass were measured by bioelectrical impedance. B-mode ultrasound measured Tibialis Anterior (TA) and Gastrocnemius Medialis (GM) anatomical cross sectional area (ACSA). The Bone Specific Physical Activity Questionnaire measured physical activity.

RESULTS

No difference in REE was found between CTRL and BeMD groups (1913 ±203 & 1786 ±324 Kcal respectively). Other physiological comparisons showed increased fat mass (+54%), decreased TA ACSA (-42%), increased GM ACSA (+25%) as well as reduced respiratory function (FVC -28%; FEV1-27%) in BeMD adults compared to controls. REE estimated from prediction equations (Schofield's) in Muscular Dystrophy were different from measured REE (P<0.05, bias = -728kcal), while the Mifflin equation was no different from measured REE (r2 = 0.58, Bias = -8kcal). Within the present BeMD, REE predicted from FFM (REE = FFM x 34.57-270; r2 = 0.85) and body mass (REE = BM x 15.65 + 421.5; r2 = 0.66), were not different from measured REE (bias equals 0 and 0.2kcals, respectively).

CONCLUSIONS

Despite no differences in REE between CTRL and BeMD adults, increased fat masses highlights the requirement for explicit nutritional guidelines, as well as maintenance of physical activity levels, where possible. Prediction equations are frequently used in clinical settings, however these have been shown to be less accurate in BeMD; therefore, the equations proposed here should be used where possible.

Authors+Show Affiliations

Health, Exercise & Active Living (HEAL) Research Centre, Manchester Metropolitan University, Cheshire Campus, Crewe, United Kingdom.The Neuromuscular Centre, Winsford, Cheshire, United Kingdom.The Neuromuscular Centre, Winsford, Cheshire, United Kingdom.Health, Exercise & Active Living (HEAL) Research Centre, Manchester Metropolitan University, Cheshire Campus, Crewe, United Kingdom.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28060911

Citation

Jacques, Matthew F., et al. "Resting Energy Expenditure in Adults With Becker's Muscular Dystrophy." PloS One, vol. 12, no. 1, 2017, pp. e0169848.
Jacques MF, Orme P, Smith J, et al. Resting Energy Expenditure in Adults with Becker's Muscular Dystrophy. PLoS ONE. 2017;12(1):e0169848.
Jacques, M. F., Orme, P., Smith, J., & Morse, C. I. (2017). Resting Energy Expenditure in Adults with Becker's Muscular Dystrophy. PloS One, 12(1), e0169848. https://doi.org/10.1371/journal.pone.0169848
Jacques MF, et al. Resting Energy Expenditure in Adults With Becker's Muscular Dystrophy. PLoS ONE. 2017;12(1):e0169848. PubMed PMID: 28060911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resting Energy Expenditure in Adults with Becker's Muscular Dystrophy. AU - Jacques,Matthew F, AU - Orme,Paul, AU - Smith,Jonathon, AU - Morse,Christopher I, Y1 - 2017/01/06/ PY - 2016/10/17/received PY - 2016/12/23/accepted PY - 2017/1/7/entrez PY - 2017/1/7/pubmed PY - 2017/8/10/medline SP - e0169848 EP - e0169848 JF - PloS one JO - PLoS ONE VL - 12 IS - 1 N2 - PURPOSE: The purpose of this study was: 1) To compare Resting energy expenditure (REE) in adult males with Becker's Muscular Dystrophy (BeMD, n = 21, 39 ±12 years) and healthy controls (CTRL, n = 12, 37 ±12 years) 2) Determine whether other physiological parameters correlate with REE in BeMD, and 3) Compare current prediction methods of REE with measured REE. METHODS: REE was calculated via indirect calorimetry using continuous, expired gas analysis following an overnight fast. Fat free mass (FFM) and fat mass were measured by bioelectrical impedance. B-mode ultrasound measured Tibialis Anterior (TA) and Gastrocnemius Medialis (GM) anatomical cross sectional area (ACSA). The Bone Specific Physical Activity Questionnaire measured physical activity. RESULTS: No difference in REE was found between CTRL and BeMD groups (1913 ±203 & 1786 ±324 Kcal respectively). Other physiological comparisons showed increased fat mass (+54%), decreased TA ACSA (-42%), increased GM ACSA (+25%) as well as reduced respiratory function (FVC -28%; FEV1-27%) in BeMD adults compared to controls. REE estimated from prediction equations (Schofield's) in Muscular Dystrophy were different from measured REE (P<0.05, bias = -728kcal), while the Mifflin equation was no different from measured REE (r2 = 0.58, Bias = -8kcal). Within the present BeMD, REE predicted from FFM (REE = FFM x 34.57-270; r2 = 0.85) and body mass (REE = BM x 15.65 + 421.5; r2 = 0.66), were not different from measured REE (bias equals 0 and 0.2kcals, respectively). CONCLUSIONS: Despite no differences in REE between CTRL and BeMD adults, increased fat masses highlights the requirement for explicit nutritional guidelines, as well as maintenance of physical activity levels, where possible. Prediction equations are frequently used in clinical settings, however these have been shown to be less accurate in BeMD; therefore, the equations proposed here should be used where possible. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/28060911/Resting_Energy_Expenditure_in_Adults_with_Becker's_Muscular_Dystrophy_ L2 - http://dx.plos.org/10.1371/journal.pone.0169848 DB - PRIME DP - Unbound Medicine ER -