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Maternal urinary paraben levels and offspring size at birth from a Chinese birth cohort.
Chemosphere. 2017 Apr; 172:29-36.C

Abstract

BACKGROUND

Parabens are suspected to impair fetal growth because of their endocrine disrupting effects. Epidemiological studies regarding the effects of prenatal exposure to parabens on birth outcomes are limited.

OBJECTIVES

Our aim was to evaluate the association between prenatal paraben exposure and size of infants at birth.

METHODS

Within the longitudinal Healthy Baby Cohort (HBC) in Hubei Province, China, we randomly selected 1006 mother-infant pairs recruited in Wuhan City in 2014. Concentrations of parabens were measured in maternal urine collected before delivery. General linear models were used to analyze the associations of maternal parabens exposure levels with birth weight and birth length.

RESULTS

The specific gravity adjusted geometric means for urinary concentrations of methyl paraben (MeP), ethyl paraben (EtP), and propyl paraben (PrP) were 5.41, 0.11, and 0.94 ng/mL, respectively. Maternal urinary concentrations of parabens tended to be positively associated with birth weight in boys, while opposite trends were found in girls, though these associations were not significant. Higher maternal urinary levels of MeP were positively associated with birth length in boys (β = 0.30, 95% CI: 0.01, 0.58 for the medium tertile, and β = 0.30, 95% CI: 0.01, 0.58 for the highest tertile compared to the lowest tertile); however, no significant associations with birth length were observed in girls.

CONCLUSIONS

Maternal urinary levels of MeP were positively associated with length at birth in boys. Besides, we did not find strong associations of the current exposure levels of parabens in Chinese pregnant women with size of infants at birth.

Authors+Show Affiliations

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Women and Children Medical and Healthcare Center of Wuhan, Wuhan, Hubei, China.CDC of Yangtze River Administration and Navigational Affairs, General Hospital of the Yangtze River Shipping, Wuhan, dc0019, China.Department of Epidemiology, Brown University, Providence, RI, USA.Women and Children Medical and Healthcare Center of Wuhan, Wuhan, Hubei, China.Women and Children Medical and Healthcare Center of Wuhan, Wuhan, Hubei, China.Department of Epidemiology, College for Public Health & Social Justice, Saint Louis University, Saint Louis, MO, USA.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: xiawei@hust.edu.cn.Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: xust@hust.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28061343

Citation

Wu, Chuansha, et al. "Maternal Urinary Paraben Levels and Offspring Size at Birth From a Chinese Birth Cohort." Chemosphere, vol. 172, 2017, pp. 29-36.
Wu C, Huo W, Li Y, et al. Maternal urinary paraben levels and offspring size at birth from a Chinese birth cohort. Chemosphere. 2017;172:29-36.
Wu, C., Huo, W., Li, Y., Zhang, B., Wan, Y., Zheng, T., Zhou, A., Chen, Z., Qian, M., Zhu, Y., Jiang, Y., Liu, H., Hu, J., Chen, X., Xu, B., Xia, W., & Xu, S. (2017). Maternal urinary paraben levels and offspring size at birth from a Chinese birth cohort. Chemosphere, 172, 29-36. https://doi.org/10.1016/j.chemosphere.2016.12.131
Wu C, et al. Maternal Urinary Paraben Levels and Offspring Size at Birth From a Chinese Birth Cohort. Chemosphere. 2017;172:29-36. PubMed PMID: 28061343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal urinary paraben levels and offspring size at birth from a Chinese birth cohort. AU - Wu,Chuansha, AU - Huo,Wenqian, AU - Li,Yuanyuan, AU - Zhang,Bin, AU - Wan,Yanjian, AU - Zheng,Tongzhang, AU - Zhou,Aifen, AU - Chen,Zhong, AU - Qian,Minzheng, AU - Zhu,Yingshuang, AU - Jiang,Yangqian, AU - Liu,Hongxiu, AU - Hu,Jie, AU - Chen,Xi, AU - Xu,Bing, AU - Xia,Wei, AU - Xu,Shunqing, Y1 - 2016/12/27/ PY - 2016/09/10/received PY - 2016/12/23/revised PY - 2016/12/26/accepted PY - 2017/1/7/pubmed PY - 2017/3/25/medline PY - 2017/1/7/entrez KW - Birth cohort KW - Birth size KW - Maternal urine KW - Parabens SP - 29 EP - 36 JF - Chemosphere JO - Chemosphere VL - 172 N2 - BACKGROUND: Parabens are suspected to impair fetal growth because of their endocrine disrupting effects. Epidemiological studies regarding the effects of prenatal exposure to parabens on birth outcomes are limited. OBJECTIVES: Our aim was to evaluate the association between prenatal paraben exposure and size of infants at birth. METHODS: Within the longitudinal Healthy Baby Cohort (HBC) in Hubei Province, China, we randomly selected 1006 mother-infant pairs recruited in Wuhan City in 2014. Concentrations of parabens were measured in maternal urine collected before delivery. General linear models were used to analyze the associations of maternal parabens exposure levels with birth weight and birth length. RESULTS: The specific gravity adjusted geometric means for urinary concentrations of methyl paraben (MeP), ethyl paraben (EtP), and propyl paraben (PrP) were 5.41, 0.11, and 0.94 ng/mL, respectively. Maternal urinary concentrations of parabens tended to be positively associated with birth weight in boys, while opposite trends were found in girls, though these associations were not significant. Higher maternal urinary levels of MeP were positively associated with birth length in boys (β = 0.30, 95% CI: 0.01, 0.58 for the medium tertile, and β = 0.30, 95% CI: 0.01, 0.58 for the highest tertile compared to the lowest tertile); however, no significant associations with birth length were observed in girls. CONCLUSIONS: Maternal urinary levels of MeP were positively associated with length at birth in boys. Besides, we did not find strong associations of the current exposure levels of parabens in Chinese pregnant women with size of infants at birth. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/28061343/Maternal_urinary_paraben_levels_and_offspring_size_at_birth_from_a_Chinese_birth_cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(16)31874-4 DB - PRIME DP - Unbound Medicine ER -