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Hepatotoxicity by herbs: a practical review of a neglected disease.
Rev Gastroenterol Peru 2016 Oct-Dec; 36(4):350-353RG

Abstract

Herbs are commonly used worldwide for the treatment of various diseases, constituting a multi-billion dollar market. Unfortunately, hepatotoxicity induced by herbs is also common. The true incidence and prevalence are not known. There is need for more strict regulations andexperimental and pre-clinical studies regarding its efficacy and safety. There is no gold standard for the diagnosis of herbs-induced liver injury (HILI) and it constitutes a diagnostic challenge for the clinician, whereestablishing causality could be cumbersome. Clinical presentation varies from asymptomatic cases with mildly abnormal liver tests to fulminant liver failure requiring liver transplantation. In this review, we will discuss the epidemiology, clinical manifestations, challenges and diagnostic approach of HILI and will also present some exemplary cases from the University of Miami, Division of Hepatology.

Authors+Show Affiliations

Division of Gastroenterology, University of Miami Leonard Miller School of Medicine, Miami, FL, USA.Division of Hepatology, Miller School of Medicine, University of Miami. Coral Gables, Florida, United States.University of Miami. Coral Gables, Florida, United States.Division of Hepatology, Miller School of Medicine, University of Miami. Coral Gables, Florida, United States.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28062872

Citation

Donet, Jean A., et al. "Hepatotoxicity By Herbs: a Practical Review of a Neglected Disease." Revista De Gastroenterologia Del Peru : Organo Oficial De La Sociedad De Gastroenterologia Del Peru, vol. 36, no. 4, 2016, pp. 350-353.
Donet JA, Sornmayura K, Gulau M, et al. Hepatotoxicity by herbs: a practical review of a neglected disease. Rev Gastroenterol Peru. 2016;36(4):350-353.
Donet, J. A., Sornmayura, K., Gulau, M., & Schiff, E. (2016). Hepatotoxicity by herbs: a practical review of a neglected disease. Revista De Gastroenterologia Del Peru : Organo Oficial De La Sociedad De Gastroenterologia Del Peru, 36(4), pp. 350-353.
Donet JA, et al. Hepatotoxicity By Herbs: a Practical Review of a Neglected Disease. Rev Gastroenterol Peru. 2016;36(4):350-353. PubMed PMID: 28062872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatotoxicity by herbs: a practical review of a neglected disease. AU - Donet,Jean A, AU - Sornmayura,Kay, AU - Gulau,Matthew, AU - Schiff,Eugene, PY - 2017/1/8/entrez PY - 2017/1/8/pubmed PY - 2017/5/26/medline SP - 350 EP - 353 JF - Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru JO - Rev Gastroenterol Peru VL - 36 IS - 4 N2 - Herbs are commonly used worldwide for the treatment of various diseases, constituting a multi-billion dollar market. Unfortunately, hepatotoxicity induced by herbs is also common. The true incidence and prevalence are not known. There is need for more strict regulations andexperimental and pre-clinical studies regarding its efficacy and safety. There is no gold standard for the diagnosis of herbs-induced liver injury (HILI) and it constitutes a diagnostic challenge for the clinician, whereestablishing causality could be cumbersome. Clinical presentation varies from asymptomatic cases with mildly abnormal liver tests to fulminant liver failure requiring liver transplantation. In this review, we will discuss the epidemiology, clinical manifestations, challenges and diagnostic approach of HILI and will also present some exemplary cases from the University of Miami, Division of Hepatology. SN - 1609-722X UR - https://www.unboundmedicine.com/medline/citation/28062872/Hepatotoxicity_by_herbs:_a_practical_review_of_a_neglected_disease_ L2 - https://medlineplus.gov/drugreactions.html DB - PRIME DP - Unbound Medicine ER -