Tags

Type your tag names separated by a space and hit enter

Mineral metabolism and cardiovascular disease in CKD.
Clin Exp Nephrol. 2017 Mar; 21(Suppl 1):53-63.CE

Abstract

The mineral bone disorder of CKD, called Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD), has a major role in the etiology and progression of cardiovascular disease in CKD patients. Since the main emphasis in CKD-MBD is on three categories (bone abnormalities, laboratory abnormalities, and vascular calcifications), we have routinely accepted ectopic cardiovascular calcifications as a central risk factor in the pathophysiology of CKD-MBD for cardiac events. However, recent compelling evidence suggests that some CKD-MBD-specific factors other than vascular calcification might contribute to the onset of cardiovascular disease. Most notable is fibroblast growth factor-23 (FGF23), which is thought to be independently associated with cardiac remodeling. Slow progression of cardiac disorders, such as vascular calcification and cardiac remodeling, characterizes cardiac disease due to CKD-MBD. In contrast, fatal arrhythmia may be induced when QT prolongation occurs with CKD-MBD treatment, such as with lower Ca dialysate or the use of calcimimetics. Sudden onset of fatal cardiac events, such as heart failure and sudden cardiac death, due to fatal arrhythmia would be another distinctive phenomenon of CKD-MBD. This may be defined as CKD-MBD-specific cardiac complex syndrome.

Authors+Show Affiliations

Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan.Division of Nephrology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-Ku, Tokyo, 153-8515, Japan. jokinobuhiko@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28062938

Citation

Fujii, Hideki, and Nobuhiko Joki. "Mineral Metabolism and Cardiovascular Disease in CKD." Clinical and Experimental Nephrology, vol. 21, no. Suppl 1, 2017, pp. 53-63.
Fujii H, Joki N. Mineral metabolism and cardiovascular disease in CKD. Clin Exp Nephrol. 2017;21(Suppl 1):53-63.
Fujii, H., & Joki, N. (2017). Mineral metabolism and cardiovascular disease in CKD. Clinical and Experimental Nephrology, 21(Suppl 1), 53-63. https://doi.org/10.1007/s10157-016-1363-8
Fujii H, Joki N. Mineral Metabolism and Cardiovascular Disease in CKD. Clin Exp Nephrol. 2017;21(Suppl 1):53-63. PubMed PMID: 28062938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mineral metabolism and cardiovascular disease in CKD. AU - Fujii,Hideki, AU - Joki,Nobuhiko, Y1 - 2017/01/06/ PY - 2016/10/01/received PY - 2016/11/24/accepted PY - 2017/1/8/pubmed PY - 2017/8/18/medline PY - 2017/1/8/entrez KW - Aortic valve calcification KW - Bradyarrhythmia KW - Coronary atherosclerosis KW - FGF23 KW - Klotho KW - Left ventricular hypertrophy KW - Sudden cardiac death KW - Valvular heart disease KW - Vitamin D SP - 53 EP - 63 JF - Clinical and experimental nephrology JO - Clin Exp Nephrol VL - 21 IS - Suppl 1 N2 - The mineral bone disorder of CKD, called Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD), has a major role in the etiology and progression of cardiovascular disease in CKD patients. Since the main emphasis in CKD-MBD is on three categories (bone abnormalities, laboratory abnormalities, and vascular calcifications), we have routinely accepted ectopic cardiovascular calcifications as a central risk factor in the pathophysiology of CKD-MBD for cardiac events. However, recent compelling evidence suggests that some CKD-MBD-specific factors other than vascular calcification might contribute to the onset of cardiovascular disease. Most notable is fibroblast growth factor-23 (FGF23), which is thought to be independently associated with cardiac remodeling. Slow progression of cardiac disorders, such as vascular calcification and cardiac remodeling, characterizes cardiac disease due to CKD-MBD. In contrast, fatal arrhythmia may be induced when QT prolongation occurs with CKD-MBD treatment, such as with lower Ca dialysate or the use of calcimimetics. Sudden onset of fatal cardiac events, such as heart failure and sudden cardiac death, due to fatal arrhythmia would be another distinctive phenomenon of CKD-MBD. This may be defined as CKD-MBD-specific cardiac complex syndrome. SN - 1437-7799 UR - https://www.unboundmedicine.com/medline/citation/28062938/Mineral_metabolism_and_cardiovascular_disease_in_CKD_ L2 - https://dx.doi.org/10.1007/s10157-016-1363-8 DB - PRIME DP - Unbound Medicine ER -