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Magnetic- and pH-responsive κ-carrageenan/chitosan complexes for controlled release of methotrexate anticancer drug.
Int J Biol Macromol. 2017 Apr; 97:209-217.IJ

Abstract

The aim of the present work was to develop green carriers for methotrexate using κ-carrageenan/chitosan complexes. Magnetic Fe3O4 nanoparticles were first synthesized in the presence of κ-carrageenan through in situ method. Then, the obtained magnetic κ-carrageenan was crosslinked using the polycation chitosan biopolymer. The physical and structural properties of hydrogels were investigated by FTIR, XRD, SEM, TEM, TGA, and VSM techniques. The pH-dependent swelling behavior of hydrogels was examined in various buffer solutions. All of the prepared hydrogels showed a high swelling capacity in basic solutions. The introduction of magnetite nanoparticles into κ-carrageenan/chitosan complexes had a significant effect on the swelling capacity of magnetic hydrogels, as the water absorbency of hydrogels decreased with increasing magnetite content. Methotrexate as an anticancer and model drug was loaded on hydrogels and the release profiles were investigated at pH=7.4 and 5.3. The methotrexate encapsulation efficiency was increased by increasing magnetite and chitosan contents. The results demonstrated that the release of methotrexate from magnetic hydrogels is pH-dependent with a high release content at pH=7.4. The release profiles were analyzed by Peppas's empirical model and the release of drug from hydrogels followed Fickian type of diffusion mechanism at both pHs.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mahdavinia GR
Polymer Research Laboratory, Department of Chemistry, Faculty of Science, University of Maragheh, P.O. Box 55181-83111, Maragheh, Iran. Electronic address: grmnia@maragheh.ac.ir.
Mosallanezhad A
Department of Materials Engineering, Faculty of Engineering, University of Maragheh, P.O. Box 55181-83111, Maragheh, Iran.
Soleymani M
Department of Chemical Engineering, Faculty of Engineering, University of Maragheh, P.O. Box 55181-83111, Maragheh, Iran.
Sabzi M
Department of Chemical Engineering, Faculty of Engineering, University of Maragheh, P.O. Box 55181-83111, Maragheh, Iran.

MeSH

Antineoplastic AgentsCarrageenanChitosanDelayed-Action PreparationsDrug CarriersDrug LiberationHydrogen-Ion ConcentrationMagnetite NanoparticlesMethotrexate

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28064053

Citation

Mahdavinia, Gholam Reza, et al. "Magnetic- and pH-responsive Κ-carrageenan/chitosan Complexes for Controlled Release of Methotrexate Anticancer Drug." International Journal of Biological Macromolecules, vol. 97, 2017, pp. 209-217.
Mahdavinia GR, Mosallanezhad A, Soleymani M, et al. Magnetic- and pH-responsive κ-carrageenan/chitosan complexes for controlled release of methotrexate anticancer drug. Int J Biol Macromol. 2017;97:209-217.
Mahdavinia, G. R., Mosallanezhad, A., Soleymani, M., & Sabzi, M. (2017). Magnetic- and pH-responsive κ-carrageenan/chitosan complexes for controlled release of methotrexate anticancer drug. International Journal of Biological Macromolecules, 97, 209-217. https://doi.org/10.1016/j.ijbiomac.2017.01.012
Mahdavinia GR, et al. Magnetic- and pH-responsive Κ-carrageenan/chitosan Complexes for Controlled Release of Methotrexate Anticancer Drug. Int J Biol Macromol. 2017;97:209-217. PubMed PMID: 28064053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic- and pH-responsive κ-carrageenan/chitosan complexes for controlled release of methotrexate anticancer drug. AU - Mahdavinia,Gholam Reza, AU - Mosallanezhad,Amirabbas, AU - Soleymani,Moslem, AU - Sabzi,Mohammad, Y1 - 2017/01/04/ PY - 2016/10/28/received PY - 2016/12/09/revised PY - 2017/01/02/accepted PY - 2017/1/9/pubmed PY - 2017/4/11/medline PY - 2017/1/9/entrez KW - Chitosan KW - Complex KW - Magnetic hydrogel KW - Methotrexate release KW - κ-Carrageenan SP - 209 EP - 217 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 97 N2 - The aim of the present work was to develop green carriers for methotrexate using κ-carrageenan/chitosan complexes. Magnetic Fe3O4 nanoparticles were first synthesized in the presence of κ-carrageenan through in situ method. Then, the obtained magnetic κ-carrageenan was crosslinked using the polycation chitosan biopolymer. The physical and structural properties of hydrogels were investigated by FTIR, XRD, SEM, TEM, TGA, and VSM techniques. The pH-dependent swelling behavior of hydrogels was examined in various buffer solutions. All of the prepared hydrogels showed a high swelling capacity in basic solutions. The introduction of magnetite nanoparticles into κ-carrageenan/chitosan complexes had a significant effect on the swelling capacity of magnetic hydrogels, as the water absorbency of hydrogels decreased with increasing magnetite content. Methotrexate as an anticancer and model drug was loaded on hydrogels and the release profiles were investigated at pH=7.4 and 5.3. The methotrexate encapsulation efficiency was increased by increasing magnetite and chitosan contents. The results demonstrated that the release of methotrexate from magnetic hydrogels is pH-dependent with a high release content at pH=7.4. The release profiles were analyzed by Peppas's empirical model and the release of drug from hydrogels followed Fickian type of diffusion mechanism at both pHs. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/28064053/Magnetic__and_pH_responsive_κ_carrageenan/chitosan_complexes_for_controlled_release_of_methotrexate_anticancer_drug_ DB - PRIME DP - Unbound Medicine ER -