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[Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze].

Abstract

During four weeks rats were learned to visit consequently 4 baited arms in the 8-armed radial maze. Picamilone (nicotinoyl-GABA) in a dose of 10 mg/kg daily accelerated rats to reach 80% level of learning (to 20-28 trials). After picamilone injections rats obtained the maximal level of short-term memory as just 3-5 trials. Piracetam in a dose of 200 mg/kg daily exerted no effects on long-term and short-term memory of rats in the radial maze.

Authors

, ,

Source

MeSH

Animals
Learning
Male
Memory
Memory, Short-Term
Piracetam
Pyrrolidinones
Rats
gamma-Aminobutyric Acid

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

2806520

Citation

Voznesenskiĭ, A G., et al. "[Comparative Study of the Effect of Picamilone and Piracetam On Learning in Rats in a Radial Maze]." Farmakologiia I Toksikologiia, vol. 52, no. 4, 1989, pp. 14-7.
Voznesenskiĭ AG, Kovalev GV, Sazhin VA. [Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze]. Farmakol Toksikol. 1989;52(4):14-7.
Voznesenskiĭ, A. G., Kovalev, G. V., & Sazhin, V. A. (1989). [Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze]. Farmakologiia I Toksikologiia, 52(4), pp. 14-7.
Voznesenskiĭ AG, Kovalev GV, Sazhin VA. [Comparative Study of the Effect of Picamilone and Piracetam On Learning in Rats in a Radial Maze]. Farmakol Toksikol. 1989;52(4):14-7. PubMed PMID: 2806520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze]. AU - Voznesenskiĭ,A G, AU - Kovalev,G V, AU - Sazhin,V A, PY - 1989/7/1/pubmed PY - 1989/7/1/medline PY - 1989/7/1/entrez SP - 14 EP - 7 JF - Farmakologiia i toksikologiia JO - Farmakol Toksikol VL - 52 IS - 4 N2 - During four weeks rats were learned to visit consequently 4 baited arms in the 8-armed radial maze. Picamilone (nicotinoyl-GABA) in a dose of 10 mg/kg daily accelerated rats to reach 80% level of learning (to 20-28 trials). After picamilone injections rats obtained the maximal level of short-term memory as just 3-5 trials. Piracetam in a dose of 200 mg/kg daily exerted no effects on long-term and short-term memory of rats in the radial maze. SN - 0014-8318 UR - https://www.unboundmedicine.com/medline/citation/2806520/ DB - PRIME DP - Unbound Medicine ER -