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Evidences for amelioration of reserpine-induced fibromyalgia in rat by low dose of gamma irradiation and duloxetine.
Int J Radiat Biol 2017; 93(5):553-560IJ

Abstract

OBJECTIVE

Fibromyalgia is a prevalent disorder characterized by chronic widespread pain and complex symptoms. This study was conducted to investigate the potential therapeutic effect of low-dose irradiation (LDI) alone or in combination with duloxetine on the reserpine-induced fibromyalgia in rats.

METHODS

Fibromyalgia was induced by administration of reserpine (1 mg/kg/s.c) for 3 consecutive days. Duloxetine (30 mg/kg, p.o) was administered 60 min before a forced swimming test (FST), and rats were exposed to a single dose of γ-radiation (0.5 Gy) 1 day before the FST.

RESULTS

Reserpine significantly increased immobility time in the FST, decreased the amount of 5-hydroxytryptamine, dopamine, and norepinephrine in cerebral cortex. It also increased malondialdehyde and nitric oxide and reduced glutathione contents in brain tissue. LDI alone or combined with duloxetine completely antagonized reserpine-induced fibromyalgia as assessed by the measured parameters. One of the most significant findings in this study was that the therapeutic effect of duloxetine was more pronounced by its combination with LDI. A possible mechanism of action of LDI and duloxetine responsible for their therapeutic effect was discussed.

CONCLUSION

On the basis of the presented evidences, it could be concluded that LDI alone or combined with duloxetine could be of value in the management of fibromyalgia.

Authors+Show Affiliations

a Department of Drug Radiation Research , National Center for Radiation Research and Technology, Atomic Energy Authority , Cairo , Egypt.a Department of Drug Radiation Research , National Center for Radiation Research and Technology, Atomic Energy Authority , Cairo , Egypt.a Department of Drug Radiation Research , National Center for Radiation Research and Technology, Atomic Energy Authority , Cairo , Egypt.a Department of Drug Radiation Research , National Center for Radiation Research and Technology, Atomic Energy Authority , Cairo , Egypt.b Department of Pharmacology and Toxicology, Faculty of Pharmacy , Cairo University , Cairo , Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28067097

Citation

Shibrya, Eman E., et al. "Evidences for Amelioration of Reserpine-induced Fibromyalgia in Rat By Low Dose of Gamma Irradiation and Duloxetine." International Journal of Radiation Biology, vol. 93, no. 5, 2017, pp. 553-560.
Shibrya EE, Radwan RR, Abd El Fattah MA, et al. Evidences for amelioration of reserpine-induced fibromyalgia in rat by low dose of gamma irradiation and duloxetine. Int J Radiat Biol. 2017;93(5):553-560.
Shibrya, E. E., Radwan, R. R., Abd El Fattah, M. A., Shabaan, E. A., & Kenawy, S. A. (2017). Evidences for amelioration of reserpine-induced fibromyalgia in rat by low dose of gamma irradiation and duloxetine. International Journal of Radiation Biology, 93(5), pp. 553-560. doi:10.1080/09553002.2017.1270475.
Shibrya EE, et al. Evidences for Amelioration of Reserpine-induced Fibromyalgia in Rat By Low Dose of Gamma Irradiation and Duloxetine. Int J Radiat Biol. 2017;93(5):553-560. PubMed PMID: 28067097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidences for amelioration of reserpine-induced fibromyalgia in rat by low dose of gamma irradiation and duloxetine. AU - Shibrya,Eman E, AU - Radwan,Rasha R, AU - Abd El Fattah,Mai A, AU - Shabaan,Esmat A, AU - Kenawy,Sanaa A, Y1 - 2017/01/09/ PY - 2017/1/10/pubmed PY - 2017/8/19/medline PY - 2017/1/10/entrez KW - Fibromyalgia KW - biogenic amines KW - duloxetine KW - forced swimming test KW - low-dose γ-irradiation KW - reserpine SP - 553 EP - 560 JF - International journal of radiation biology JO - Int. J. Radiat. Biol. VL - 93 IS - 5 N2 - OBJECTIVE: Fibromyalgia is a prevalent disorder characterized by chronic widespread pain and complex symptoms. This study was conducted to investigate the potential therapeutic effect of low-dose irradiation (LDI) alone or in combination with duloxetine on the reserpine-induced fibromyalgia in rats. METHODS: Fibromyalgia was induced by administration of reserpine (1 mg/kg/s.c) for 3 consecutive days. Duloxetine (30 mg/kg, p.o) was administered 60 min before a forced swimming test (FST), and rats were exposed to a single dose of γ-radiation (0.5 Gy) 1 day before the FST. RESULTS: Reserpine significantly increased immobility time in the FST, decreased the amount of 5-hydroxytryptamine, dopamine, and norepinephrine in cerebral cortex. It also increased malondialdehyde and nitric oxide and reduced glutathione contents in brain tissue. LDI alone or combined with duloxetine completely antagonized reserpine-induced fibromyalgia as assessed by the measured parameters. One of the most significant findings in this study was that the therapeutic effect of duloxetine was more pronounced by its combination with LDI. A possible mechanism of action of LDI and duloxetine responsible for their therapeutic effect was discussed. CONCLUSION: On the basis of the presented evidences, it could be concluded that LDI alone or combined with duloxetine could be of value in the management of fibromyalgia. SN - 1362-3095 UR - https://www.unboundmedicine.com/medline/citation/28067097/Evidences_for_amelioration_of_reserpine_induced_fibromyalgia_in_rat_by_low_dose_of_gamma_irradiation_and_duloxetine_ L2 - http://www.tandfonline.com/doi/full/10.1080/09553002.2017.1270475 DB - PRIME DP - Unbound Medicine ER -