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Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials.
Nutrients. 2017 Jan 06; 9(1)N

Abstract

Arthritis patients often take fish oil supplements to alleviate symptoms, but limited evidence exists regarding their efficacy. The objective was to evaluate whether marine oil supplements reduce pain and/or improve other clinical outcomes in patients with arthritis. Six databases were searched systematically (24 February 2015). We included randomized trials of oral supplements of all marine oils compared with a control in arthritis patients. The internal validity was assessed using the Cochrane Risk of Bias tool and heterogeneity was explored using restricted maximum of likelihood (REML)-based meta-regression analysis. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to rate the overall quality of the evidence. Forty-two trials were included; 30 trials reported complete data on pain. The standardized mean difference (SMD) suggested a favorable effect (-0.24; 95% confidence interval, CI, -0.42 to -0.07; heterogeneity, I² = 63%. A significant effect was found in patients with rheumatoid arthritis (22 trials; -0.21; 95% CI, -0.42 to -0.004) and other or mixed diagnoses (3 trials; -0.63; 95% CI, -1.20 to -0.06), but not in osteoarthritis patients (5 trials; -0.17; 95% CI, -0.57-0.24). The evidence for using marine oil to alleviate pain in arthritis patients was overall of low quality, but of moderate quality in rheumatoid arthritis patients.

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Authors+Show Affiliations

Senftleber NK
Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Copenhagen F, Denmark. ninnaks@hotmail.com. Department of Nutrition, Exercise and Sports, University of Copenhagen, 1958 FC Copenhagen, Denmark. ninnaks@hotmail.com.
Nielsen SM
Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Copenhagen F, Denmark. sabrina.mai.nielsen@regionh.dk. Department of Nutrition, Exercise and Sports, University of Copenhagen, 1958 FC Copenhagen, Denmark. sabrina.mai.nielsen@regionh.dk.
Andersen JR
Department of Nutrition, Exercise and Sports, University of Copenhagen, 1958 FC Copenhagen, Denmark. jra@nexs.ku.dk.
Bliddal H
Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Copenhagen F, Denmark. henning.bliddal@regionh.dk.
Tarp S
Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Copenhagen F, Denmark. simon.tarp@regionh.dk.
Lauritzen L
Department of Nutrition, Exercise and Sports, University of Copenhagen, 1958 FC Copenhagen, Denmark. ll@nexs.ku.dk.
Furst DE
Division of Rheumatology, University of California, Los Angeles, CA 90095, USA. defurst@mednet.ucla.edu.
Suarez-Almazor ME
The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. msalmazor@mdanderson.org.
Lyddiatt A
Musculoskeletal Group, Cochrane Collaboration, Ottawa, ON K1H 8L6, Canada. lyddiatt@lyddiatt.ca.
Christensen R
Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Copenhagen F, Denmark. robin.christensen@regionh.dk.

MeSH

Arthritis, RheumatoidDatabases, FactualDietary SupplementsDocosahexaenoic AcidsEicosapentaenoic AcidFish OilsHumansInflammationOsteoarthritisPainRandomized Controlled Trials as TopicTreatment Outcomealpha-Linolenic Acid

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

28067815

Citation

Senftleber, Ninna K., et al. "Marine Oil Supplements for Arthritis Pain: a Systematic Review and Meta-Analysis of Randomized Trials." Nutrients, vol. 9, no. 1, 2017.
Senftleber NK, Nielsen SM, Andersen JR, et al. Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials. Nutrients. 2017;9(1).
Senftleber, N. K., Nielsen, S. M., Andersen, J. R., Bliddal, H., Tarp, S., Lauritzen, L., Furst, D. E., Suarez-Almazor, M. E., Lyddiatt, A., & Christensen, R. (2017). Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials. Nutrients, 9(1). https://doi.org/10.3390/nu9010042
Senftleber NK, et al. Marine Oil Supplements for Arthritis Pain: a Systematic Review and Meta-Analysis of Randomized Trials. Nutrients. 2017 Jan 6;9(1) PubMed PMID: 28067815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials. AU - Senftleber,Ninna K, AU - Nielsen,Sabrina M, AU - Andersen,Jens R, AU - Bliddal,Henning, AU - Tarp,Simon, AU - Lauritzen,Lotte, AU - Furst,Daniel E, AU - Suarez-Almazor,Maria E, AU - Lyddiatt,Anne, AU - Christensen,Robin, Y1 - 2017/01/06/ PY - 2016/10/20/received PY - 2016/12/09/revised PY - 2016/12/21/accepted PY - 2017/1/10/entrez PY - 2017/1/10/pubmed PY - 2017/6/14/medline KW - arthritis KW - complementary medicine KW - fish oil KW - joint pain KW - marine oil KW - meta-analysis KW - randomized controlled trials KW - rheumatology JF - Nutrients JO - Nutrients VL - 9 IS - 1 N2 - Arthritis patients often take fish oil supplements to alleviate symptoms, but limited evidence exists regarding their efficacy. The objective was to evaluate whether marine oil supplements reduce pain and/or improve other clinical outcomes in patients with arthritis. Six databases were searched systematically (24 February 2015). We included randomized trials of oral supplements of all marine oils compared with a control in arthritis patients. The internal validity was assessed using the Cochrane Risk of Bias tool and heterogeneity was explored using restricted maximum of likelihood (REML)-based meta-regression analysis. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to rate the overall quality of the evidence. Forty-two trials were included; 30 trials reported complete data on pain. The standardized mean difference (SMD) suggested a favorable effect (-0.24; 95% confidence interval, CI, -0.42 to -0.07; heterogeneity, I² = 63%. A significant effect was found in patients with rheumatoid arthritis (22 trials; -0.21; 95% CI, -0.42 to -0.004) and other or mixed diagnoses (3 trials; -0.63; 95% CI, -1.20 to -0.06), but not in osteoarthritis patients (5 trials; -0.17; 95% CI, -0.57-0.24). The evidence for using marine oil to alleviate pain in arthritis patients was overall of low quality, but of moderate quality in rheumatoid arthritis patients. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/28067815/Marine_Oil_Supplements_for_Arthritis_Pain:_A_Systematic_Review_and_Meta_Analysis_of_Randomized_Trials_ DB - PRIME DP - Unbound Medicine ER -