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Effect of Phenolic Compounds from Elderflowers on Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells.
Molecules. 2017 Jan 06; 22(1)M

Abstract

Type 2 diabetes (T2D) is manifested by progressive metabolic impairments in tissues such as skeletal muscle and liver, and these tissues become less responsive to insulin, leading to hyperglycemia. In the present study, stimulation of glucose and oleic acid uptake by elderflower extracts, constituents and metabolites were tested in vitro using the HepG2 hepatocellular liver carcinoma cell line and human skeletal muscle cells. Among the crude extracts, the 96% EtOH extract showed the highest increase in glucose and oleic acid uptake in human skeletal muscle cells and HepG2-cells. The flavonoids and phenolic acids contained therein were potent stimulators of glucose and fatty acid uptake in a dose-dependent manner. Most of the phenolic constituents and several of the metabolites showed high antioxidant activity and showed considerably higher α-amylase and α-glucosidase inhibition than acarbose. Elderflower might therefore be valuable as a functional food against diabetes.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway. g.t.t.ho@farmasi.uio.no.Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway. e.t.kase@farmasi.uio.no.Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway. helle.wangensteen@farmasi.uio.no.Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway. hilde.barsett@farmasi.uio.no.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28067838

Citation

Ho, Giang Thanh Thi, et al. "Effect of Phenolic Compounds From Elderflowers On Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells." Molecules (Basel, Switzerland), vol. 22, no. 1, 2017.
Ho GT, Kase ET, Wangensteen H, et al. Effect of Phenolic Compounds from Elderflowers on Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells. Molecules. 2017;22(1).
Ho, G. T., Kase, E. T., Wangensteen, H., & Barsett, H. (2017). Effect of Phenolic Compounds from Elderflowers on Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells. Molecules (Basel, Switzerland), 22(1). https://doi.org/10.3390/molecules22010090
Ho GT, et al. Effect of Phenolic Compounds From Elderflowers On Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells. Molecules. 2017 Jan 6;22(1) PubMed PMID: 28067838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Phenolic Compounds from Elderflowers on Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells. AU - Ho,Giang Thanh Thi, AU - Kase,Eili Tranheim, AU - Wangensteen,Helle, AU - Barsett,Hilde, Y1 - 2017/01/06/ PY - 2016/10/31/received PY - 2016/12/19/revised PY - 2016/12/29/accepted PY - 2017/1/10/entrez PY - 2017/1/10/pubmed PY - 2017/4/22/medline KW - HepG2-cell KW - Sambucus nigra KW - antioxidant KW - elderflower KW - glucose uptake KW - human skeletal muscle KW - metabolic disorder KW - oleic acid uptake KW - type 2 diabetes JF - Molecules (Basel, Switzerland) JO - Molecules VL - 22 IS - 1 N2 - Type 2 diabetes (T2D) is manifested by progressive metabolic impairments in tissues such as skeletal muscle and liver, and these tissues become less responsive to insulin, leading to hyperglycemia. In the present study, stimulation of glucose and oleic acid uptake by elderflower extracts, constituents and metabolites were tested in vitro using the HepG2 hepatocellular liver carcinoma cell line and human skeletal muscle cells. Among the crude extracts, the 96% EtOH extract showed the highest increase in glucose and oleic acid uptake in human skeletal muscle cells and HepG2-cells. The flavonoids and phenolic acids contained therein were potent stimulators of glucose and fatty acid uptake in a dose-dependent manner. Most of the phenolic constituents and several of the metabolites showed high antioxidant activity and showed considerably higher α-amylase and α-glucosidase inhibition than acarbose. Elderflower might therefore be valuable as a functional food against diabetes. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/28067838/Effect_of_Phenolic_Compounds_from_Elderflowers_on_Glucose__and_Fatty_Acid_Uptake_in_Human_Myotubes_and_HepG2_Cells_ L2 - https://www.mdpi.com/resolver?pii=molecules22010090 DB - PRIME DP - Unbound Medicine ER -