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Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application.
Prog Lipid Res 2017; 66:1-13PL

Abstract

A body of evidence has implicated dietary deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and etiology of recurrent mood disorders including major depressive disorder (MDD) and bipolar disorder. Cross-national and cross-sectional evidence suggests that greater habitual intake of n-3 PUFA is associated with reduced risk for developing mood symptoms. Meta-analyses provide strong evidence that patients with mood disorders exhibit low blood n-3 PUFA levels which are associated with increased risk for the initial development of mood symptoms in response to inflammation. While the etiology of this n-3 PUFA deficit may be multifactorial, n-3 PUFA supplementation is sufficient to correct this deficit and may also have antidepressant effects. Rodent studies suggest that n-3 PUFA deficiency during perinatal development can recapitulate key neuropathological, neurochemical, and behavioral features associated with mood disorders. Clinical neuroimaging studies suggest that low n-3 PUFA biostatus is associated with abnormalities in cortical structure and function also observed in mood disorders. Collectively, these findings implicate dietary n-3 PUFA insufficiency, particularly during development, in the pathophysiology of mood dysregulation, and support implementation of routine screening for and treatment of n-3 PUFA deficiency in patients with mood disorders.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45219-0516, USA; Lindner Center of HOPE, Mason, OH, USA.Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45224, USA.Department of Pathology, University of Cincinnati, Cincinnati, OH 45237, USA.Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45219-0516, USA. Electronic address: robert.mcnamara@uc.edu.

Pub Type(s)

Journal Article
Review
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28069365

Citation

Messamore, Erik, et al. "Polyunsaturated Fatty Acids and Recurrent Mood Disorders: Phenomenology, Mechanisms, and Clinical Application." Progress in Lipid Research, vol. 66, 2017, pp. 1-13.
Messamore E, Almeida DM, Jandacek RJ, et al. Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application. Prog Lipid Res. 2017;66:1-13.
Messamore, E., Almeida, D. M., Jandacek, R. J., & McNamara, R. K. (2017). Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application. Progress in Lipid Research, 66, pp. 1-13. doi:10.1016/j.plipres.2017.01.001.
Messamore E, et al. Polyunsaturated Fatty Acids and Recurrent Mood Disorders: Phenomenology, Mechanisms, and Clinical Application. Prog Lipid Res. 2017;66:1-13. PubMed PMID: 28069365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application. AU - Messamore,Erik, AU - Almeida,Daniel M, AU - Jandacek,Ronald J, AU - McNamara,Robert K, Y1 - 2017/01/06/ PY - 2016/07/19/received PY - 2016/12/20/revised PY - 2017/01/05/accepted PY - 2017/1/11/pubmed PY - 2017/12/26/medline PY - 2017/1/11/entrez KW - Bipolar disorder KW - Docosahexaenoic acid (DHA) KW - Eicosapentaenoic acid (EPA) KW - Major depressive disorder KW - Omega-3 fatty acids SP - 1 EP - 13 JF - Progress in lipid research JO - Prog. Lipid Res. VL - 66 N2 - A body of evidence has implicated dietary deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and etiology of recurrent mood disorders including major depressive disorder (MDD) and bipolar disorder. Cross-national and cross-sectional evidence suggests that greater habitual intake of n-3 PUFA is associated with reduced risk for developing mood symptoms. Meta-analyses provide strong evidence that patients with mood disorders exhibit low blood n-3 PUFA levels which are associated with increased risk for the initial development of mood symptoms in response to inflammation. While the etiology of this n-3 PUFA deficit may be multifactorial, n-3 PUFA supplementation is sufficient to correct this deficit and may also have antidepressant effects. Rodent studies suggest that n-3 PUFA deficiency during perinatal development can recapitulate key neuropathological, neurochemical, and behavioral features associated with mood disorders. Clinical neuroimaging studies suggest that low n-3 PUFA biostatus is associated with abnormalities in cortical structure and function also observed in mood disorders. Collectively, these findings implicate dietary n-3 PUFA insufficiency, particularly during development, in the pathophysiology of mood dysregulation, and support implementation of routine screening for and treatment of n-3 PUFA deficiency in patients with mood disorders. SN - 1873-2194 UR - https://www.unboundmedicine.com/medline/citation/28069365/Polyunsaturated_fatty_acids_and_recurrent_mood_disorders:_Phenomenology_mechanisms_and_clinical_application_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-7827(16)30035-2 DB - PRIME DP - Unbound Medicine ER -