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Short-term treatment with oral amiodarone resulting in bilateral optic neuropathy and permanent blindness.
BMJ Case Rep. 2017 Jan 09; 2017BC

Abstract

A 66-year-old man was hospitalised due to worsening of his atrial fibrillation, and successfully underwent an electrocardioversion to restore sinus rhythm. He was discharged with a prescription of 600 mg amiodarone daily to retain the sinus rhythm prospectively. 3 weeks after discharge, he noticed that his vision became blurry with cloudy areas spreading throughout his field of view on both eyes simultaneously. The visual symptoms gradually worsened throughout the following 5 months, and the patient was hospitalised in the department of ophthalmology. At this point, his vision had dramatically decreased and visual acuity was measured to 0.05 (1.3 LogMAR) on both eyes. After a thorough medical examination, the patient was diagnosed with an amiodarone-induced toxic optic neuropathy. Regular follow-ups conducted throughout 7 years have shown that the patient's vision has stabilised, but remains limited to the ability of recognising hand motions on both eyes, thus characterising him as blind.

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Authors+Show Affiliations

Knudsen A
University of Southern Denmark, Faculty of Health Sciences, Odense M, Denmark.

MeSH

Administration, OralAftercareAgedAmiodaroneAnti-Arrhythmia AgentsAtrial FibrillationBlindnessDiagnosis, DifferentialHumansMaleOptic Nerve Diseases

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28069784

Citation

Knudsen, Arnon. "Short-term Treatment With Oral Amiodarone Resulting in Bilateral Optic Neuropathy and Permanent Blindness." BMJ Case Reports, vol. 2017, 2017.
Knudsen A. Short-term treatment with oral amiodarone resulting in bilateral optic neuropathy and permanent blindness. BMJ Case Rep. 2017;2017.
Knudsen, A. (2017). Short-term treatment with oral amiodarone resulting in bilateral optic neuropathy and permanent blindness. BMJ Case Reports, 2017. https://doi.org/10.1136/bcr-2016-217436
Knudsen A. Short-term Treatment With Oral Amiodarone Resulting in Bilateral Optic Neuropathy and Permanent Blindness. BMJ Case Rep. 2017 Jan 9;2017 PubMed PMID: 28069784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term treatment with oral amiodarone resulting in bilateral optic neuropathy and permanent blindness. A1 - Knudsen,Arnon, Y1 - 2017/01/09/ PY - 2017/1/11/entrez PY - 2017/1/11/pubmed PY - 2017/3/7/medline JF - BMJ case reports JO - BMJ Case Rep VL - 2017 N2 - A 66-year-old man was hospitalised due to worsening of his atrial fibrillation, and successfully underwent an electrocardioversion to restore sinus rhythm. He was discharged with a prescription of 600 mg amiodarone daily to retain the sinus rhythm prospectively. 3 weeks after discharge, he noticed that his vision became blurry with cloudy areas spreading throughout his field of view on both eyes simultaneously. The visual symptoms gradually worsened throughout the following 5 months, and the patient was hospitalised in the department of ophthalmology. At this point, his vision had dramatically decreased and visual acuity was measured to 0.05 (1.3 LogMAR) on both eyes. After a thorough medical examination, the patient was diagnosed with an amiodarone-induced toxic optic neuropathy. Regular follow-ups conducted throughout 7 years have shown that the patient's vision has stabilised, but remains limited to the ability of recognising hand motions on both eyes, thus characterising him as blind. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/28069784/Short_term_treatment_with_oral_amiodarone_resulting_in_bilateral_optic_neuropathy_and_permanent_blindness_ DB - PRIME DP - Unbound Medicine ER -