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Meat intake and risk of diverticulitis among men.
Gut 2018; 67(3):466-472Gut

Abstract

OBJECTIVE

Diverticulitis is a common disease with a substantial clinical and economic burden. Besides dietary fibre, the role of other foods in the prevention of diverticulitis is underexplored.

DESIGN

We prospectively examined the association between consumption of meat (total red meat, red unprocessed meat, red processed meat, poultry and fish) with risk of incident diverticulitis among 46 461 men enrolled in the Health Professionals Follow-Up Study (1986-2012). Cox proportional hazards models were used to compute relative risks (RRs) and 95% CIs.

RESULTS

During 651 970 person-years of follow-up, we documented 764 cases of incident diverticulitis. Compared with men in the lowest quintile (Q1) of total red meat consumption, men in the highest quintile (Q5) had a multivariable RR of 1.58 (95% CI 1.19 to 2.11; p for trend=0.01). The increase in risk was non-linear, plateauing after six servings per week (p for non-linearity=0.002). The association was stronger for unprocessed red meat (RR for Q5 vs Q1: 1.51; 95% CI 1.12 to 2.03; p for trend=0.03) than for processed red meat (RR for Q5 vs Q1: 1.03; 95% CI 0.78 to 1.35; p for trend=0.26). Higher consumption of poultry or fish was not associated with risk of diverticulitis. However, the substitution of poultry or fish for one serving of unprocessed red meat per day was associated with a decrease in risk of diverticulitis (multivariable RR 0.80; 95% CI 0.63 to 0.99).

CONCLUSIONS

Red meat intake, particularly unprocessed red meat, was associated with an increased risk of diverticulitis. The findings provide practical dietary guidance for patients at risk of diverticulitis.

Authors+Show Affiliations

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.Division of Gastroenterology, University of Washington School of Medicine, Harborview Medical Center, Seattle, Washington, USA.Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.Tufts University School of Medicine, Boston, Massachusetts, USA.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28069830

Citation

Cao, Yin, et al. "Meat Intake and Risk of Diverticulitis Among Men." Gut, vol. 67, no. 3, 2018, pp. 466-472.
Cao Y, Strate LL, Keeley BR, et al. Meat intake and risk of diverticulitis among men. Gut. 2018;67(3):466-472.
Cao, Y., Strate, L. L., Keeley, B. R., Tam, I., Wu, K., Giovannucci, E. L., & Chan, A. T. (2018). Meat intake and risk of diverticulitis among men. Gut, 67(3), pp. 466-472. doi:10.1136/gutjnl-2016-313082.
Cao Y, et al. Meat Intake and Risk of Diverticulitis Among Men. Gut. 2018;67(3):466-472. PubMed PMID: 28069830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meat intake and risk of diverticulitis among men. AU - Cao,Yin, AU - Strate,Lisa L, AU - Keeley,Brieze R, AU - Tam,Idy, AU - Wu,Kana, AU - Giovannucci,Edward L, AU - Chan,Andrew T, Y1 - 2017/01/09/ PY - 2016/09/20/received PY - 2016/11/04/revised PY - 2016/11/20/accepted PY - 2017/1/11/pubmed PY - 2018/3/17/medline PY - 2017/1/11/entrez KW - DIETARY FACTORS KW - DIVERTICULAR DISEASE KW - EPIDEMIOLOGY SP - 466 EP - 472 JF - Gut JO - Gut VL - 67 IS - 3 N2 - OBJECTIVE: Diverticulitis is a common disease with a substantial clinical and economic burden. Besides dietary fibre, the role of other foods in the prevention of diverticulitis is underexplored. DESIGN: We prospectively examined the association between consumption of meat (total red meat, red unprocessed meat, red processed meat, poultry and fish) with risk of incident diverticulitis among 46 461 men enrolled in the Health Professionals Follow-Up Study (1986-2012). Cox proportional hazards models were used to compute relative risks (RRs) and 95% CIs. RESULTS: During 651 970 person-years of follow-up, we documented 764 cases of incident diverticulitis. Compared with men in the lowest quintile (Q1) of total red meat consumption, men in the highest quintile (Q5) had a multivariable RR of 1.58 (95% CI 1.19 to 2.11; p for trend=0.01). The increase in risk was non-linear, plateauing after six servings per week (p for non-linearity=0.002). The association was stronger for unprocessed red meat (RR for Q5 vs Q1: 1.51; 95% CI 1.12 to 2.03; p for trend=0.03) than for processed red meat (RR for Q5 vs Q1: 1.03; 95% CI 0.78 to 1.35; p for trend=0.26). Higher consumption of poultry or fish was not associated with risk of diverticulitis. However, the substitution of poultry or fish for one serving of unprocessed red meat per day was associated with a decrease in risk of diverticulitis (multivariable RR 0.80; 95% CI 0.63 to 0.99). CONCLUSIONS: Red meat intake, particularly unprocessed red meat, was associated with an increased risk of diverticulitis. The findings provide practical dietary guidance for patients at risk of diverticulitis. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/28069830/Meat_intake_and_risk_of_diverticulitis_among_men_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=28069830 DB - PRIME DP - Unbound Medicine ER -