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Behavioral evidence for the abuse potential of the novel synthetic cathinone alpha-pyrrolidinopentiothiophenone (PVT) in rodents.
Psychopharmacology (Berl). 2017 Mar; 234(5):857-867.P

Abstract

RATIONALE

Synthetic cathinones are chemical derivatives of cathinone that are pharmacologically similar to cocaine and methamphetamine. Recently, abuse of synthetic cathinones among young people has increased.

OBJECTIVES

The present study aimed to characterize the behavioral effects of alpha-pyrrolidinopentiothiophenone (PVT), an analog of alpha-pyrrolidinovalerophenone and second-generation synthetic cathinone, as well as to evaluate its abuse potential, using conditioned place preference, intravenous self-administration (SA), and drug discrimination paradigms in rodent models.

RESULTS

Alpha-PVT produced a significant place preference in mice at doses of 10, 30, and 50 mg/kg. In the SA experiment, alpha-PVT (0.1, 0.3, and 1.0 mg/kg/infusion) produced an inverted U-shaped dose-effect curve in rats. Under a progressive ratio schedule of reinforcement, there appeared to be a positive relationship between alpha-PVT dose and the breakpoints for alpha-PVT reinforcement. Additionally, alpha-PVT fully substituted for the discriminative stimulus effects of both cocaine and methamphetamine in rats.

CONCLUSIONS

Our results indicate that alpha-PVT has rewarding and reinforcing effects and shares the interoceptive effects of cocaine and methamphetamine. To the best of our knowledge, the present study is the first to show that alpha-PVT has reinforcing properties when delivered on its own, which suggests possible abuse liability in humans.

Authors+Show Affiliations

Uimyung Research Institute for Neuroscience, School of Pharmacy, Sahmyook University, 26-21 Kongreung-2-dong, Hwarangro-815 Nowon-gu, Seoul, 01795, Republic of Korea.Research Center for Safety Pharmacology, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea.Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.Laboratory of Medicinal Chemistry, School of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea.College of Pharmacy, Keimyung University, 1095 Dalgubeoldaero, Dalseo-gu, Daegu, 42601, Republic of Korea.Uimyung Research Institute for Neuroscience, School of Pharmacy, Sahmyook University, 26-21 Kongreung-2-dong, Hwarangro-815 Nowon-gu, Seoul, 01795, Republic of Korea.Research Center for Safety Pharmacology, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea.Research Center for Safety Pharmacology, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea. ssyoon@kitox.re.kr. Human and Environmental Toxicology, University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea. ssyoon@kitox.re.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28070621

Citation

Cheong, Jae Hoon, et al. "Behavioral Evidence for the Abuse Potential of the Novel Synthetic Cathinone Alpha-pyrrolidinopentiothiophenone (PVT) in Rodents." Psychopharmacology, vol. 234, no. 5, 2017, pp. 857-867.
Cheong JH, Choi MJ, Jang CG, et al. Behavioral evidence for the abuse potential of the novel synthetic cathinone alpha-pyrrolidinopentiothiophenone (PVT) in rodents. Psychopharmacology (Berl). 2017;234(5):857-867.
Cheong, J. H., Choi, M. J., Jang, C. G., Lee, Y. S., Lee, S., Kim, H. J., Seo, J. W., & Yoon, S. S. (2017). Behavioral evidence for the abuse potential of the novel synthetic cathinone alpha-pyrrolidinopentiothiophenone (PVT) in rodents. Psychopharmacology, 234(5), 857-867. https://doi.org/10.1007/s00213-017-4526-8
Cheong JH, et al. Behavioral Evidence for the Abuse Potential of the Novel Synthetic Cathinone Alpha-pyrrolidinopentiothiophenone (PVT) in Rodents. Psychopharmacology (Berl). 2017;234(5):857-867. PubMed PMID: 28070621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioral evidence for the abuse potential of the novel synthetic cathinone alpha-pyrrolidinopentiothiophenone (PVT) in rodents. AU - Cheong,Jae Hoon, AU - Choi,Mee Jung, AU - Jang,Choon-Gon, AU - Lee,Yong Sup, AU - Lee,Sooyeun, AU - Kim,Hee Jin, AU - Seo,Joung-Wook, AU - Yoon,Seong Shoon, Y1 - 2017/01/09/ PY - 2016/09/27/received PY - 2016/12/29/accepted PY - 2017/1/11/pubmed PY - 2017/12/1/medline PY - 2017/1/11/entrez KW - Abuse potential KW - Alpha-pyrrolidinopentiothiophenone KW - Conditioned place preference KW - Drug discrimination KW - Rodents KW - Self-administration KW - Synthetic cathinone derivatives SP - 857 EP - 867 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 234 IS - 5 N2 - RATIONALE: Synthetic cathinones are chemical derivatives of cathinone that are pharmacologically similar to cocaine and methamphetamine. Recently, abuse of synthetic cathinones among young people has increased. OBJECTIVES: The present study aimed to characterize the behavioral effects of alpha-pyrrolidinopentiothiophenone (PVT), an analog of alpha-pyrrolidinovalerophenone and second-generation synthetic cathinone, as well as to evaluate its abuse potential, using conditioned place preference, intravenous self-administration (SA), and drug discrimination paradigms in rodent models. RESULTS: Alpha-PVT produced a significant place preference in mice at doses of 10, 30, and 50 mg/kg. In the SA experiment, alpha-PVT (0.1, 0.3, and 1.0 mg/kg/infusion) produced an inverted U-shaped dose-effect curve in rats. Under a progressive ratio schedule of reinforcement, there appeared to be a positive relationship between alpha-PVT dose and the breakpoints for alpha-PVT reinforcement. Additionally, alpha-PVT fully substituted for the discriminative stimulus effects of both cocaine and methamphetamine in rats. CONCLUSIONS: Our results indicate that alpha-PVT has rewarding and reinforcing effects and shares the interoceptive effects of cocaine and methamphetamine. To the best of our knowledge, the present study is the first to show that alpha-PVT has reinforcing properties when delivered on its own, which suggests possible abuse liability in humans. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/28070621/Behavioral_evidence_for_the_abuse_potential_of_the_novel_synthetic_cathinone_alpha_pyrrolidinopentiothiophenone__PVT__in_rodents_ L2 - https://dx.doi.org/10.1007/s00213-017-4526-8 DB - PRIME DP - Unbound Medicine ER -