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Immunological findings in whole and parotid saliva of patients with ulcerative colitis and healthy controls.
Hepatogastroenterology 1989; 36(4):185-7H

Abstract

Since abnormal concentrations of immunoglobulins have previously been found in saliva of patients with Crohn's disease, we measured the concentrations of IgA, IgM, and IgG in whole and parotid saliva with the ELISA technique in 20 patients with ulcerative colitis (UC) and 19 healthy control subjects. IgA predominated in whole and parotid saliva in both patients and controls, and in both groups whole saliva had higher levels of IgA, IgM, and IgG than did parotid saliva. IgA and IgG levels were significantly (p less than 0.05) elevated in the whole saliva of UC patients as compared with the controls. IgM was also increased, but the difference did not reach statistical significance. No correlation was found between immunoglobulin levels and age, sex, duration of the disease, and extent of colitis. A significant negative correlation was found between the activity of the disease and the concentration of IgA in whole saliva. The present study therefore suggests that the previously reported abnormalities in the saliva of patients with Crohn's disease and presented as possible evidence for a disease affecting the whole of the gastrointestinal tract, are not specific, since similar findings are observed in UC.

Authors+Show Affiliations

Department of Gastroenterology, Leiden University Hospital, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2807134

Citation

Crama-Bohbouth, G, et al. "Immunological Findings in Whole and Parotid Saliva of Patients With Ulcerative Colitis and Healthy Controls." Hepato-gastroenterology, vol. 36, no. 4, 1989, pp. 185-7.
Crama-Bohbouth G, Peña AS, Verspaget HW, et al. Immunological findings in whole and parotid saliva of patients with ulcerative colitis and healthy controls. Hepatogastroenterology. 1989;36(4):185-7.
Crama-Bohbouth, G., Peña, A. S., Verspaget, H. W., vd Zon, A., Biemond, I., Weterman, I. T., & Lamers, C. B. (1989). Immunological findings in whole and parotid saliva of patients with ulcerative colitis and healthy controls. Hepato-gastroenterology, 36(4), pp. 185-7.
Crama-Bohbouth G, et al. Immunological Findings in Whole and Parotid Saliva of Patients With Ulcerative Colitis and Healthy Controls. Hepatogastroenterology. 1989;36(4):185-7. PubMed PMID: 2807134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunological findings in whole and parotid saliva of patients with ulcerative colitis and healthy controls. AU - Crama-Bohbouth,G, AU - Peña,A S, AU - Verspaget,H W, AU - vd Zon,A, AU - Biemond,I, AU - Weterman,I T, AU - Lamers,C B, PY - 1989/8/1/pubmed PY - 1989/8/1/medline PY - 1989/8/1/entrez SP - 185 EP - 7 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 36 IS - 4 N2 - Since abnormal concentrations of immunoglobulins have previously been found in saliva of patients with Crohn's disease, we measured the concentrations of IgA, IgM, and IgG in whole and parotid saliva with the ELISA technique in 20 patients with ulcerative colitis (UC) and 19 healthy control subjects. IgA predominated in whole and parotid saliva in both patients and controls, and in both groups whole saliva had higher levels of IgA, IgM, and IgG than did parotid saliva. IgA and IgG levels were significantly (p less than 0.05) elevated in the whole saliva of UC patients as compared with the controls. IgM was also increased, but the difference did not reach statistical significance. No correlation was found between immunoglobulin levels and age, sex, duration of the disease, and extent of colitis. A significant negative correlation was found between the activity of the disease and the concentration of IgA in whole saliva. The present study therefore suggests that the previously reported abnormalities in the saliva of patients with Crohn's disease and presented as possible evidence for a disease affecting the whole of the gastrointestinal tract, are not specific, since similar findings are observed in UC. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/2807134/Immunological_findings_in_whole_and_parotid_saliva_of_patients_with_ulcerative_colitis_and_healthy_controls_ L2 - http://www.diseaseinfosearch.org/result/7285 DB - PRIME DP - Unbound Medicine ER -