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Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease.
Mov Disord 2017; 32(4):610-614MD

Abstract

BACKGROUND

Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD.

OBJECTIVES

This study investigated heart rate variability in LRRK2-associated PD.

METHODS

Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls. Linear regression modelling compared time and frequency domain values, adjusting for age, sex, heart rate, and disease duration.

RESULTS

Low-frequency power and the ratio of low-high frequency power were reduced in idiopathic PD versus controls (P < .008, P < .029 respectively). In contrast, individuals with LRRK2-associated PD were not statistically different from controls in any parameter measured. Furthermore, all parameters trended toward being higher in LRRK2-associated PD when compared with idiopathic PD.

CONCLUSIONS

Heart rate variability may remain intact in LRRK2-associated PD, adding to a growing literature supporting clinical-pathologic differences between LRRK2-associated and idiopathic PD. © 2017 International Parkinson and Movement Disorder Society.

Authors+Show Affiliations

Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.The Parkinson's Institute and Clinical Center, Sunnyvale, California, USA.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.The Parkinson's Institute and Clinical Center, Sunnyvale, California, USA.The Parkinson's Institute and Clinical Center, Sunnyvale, California, USA.The Parkinson's Institute and Clinical Center, Sunnyvale, California, USA.Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.The Parkinson's Institute and Clinical Center, Sunnyvale, California, USA.University of California, San Francisco, San Francisco, California, USA. San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.The Parkinson's Institute and Clinical Center, Sunnyvale, California, USA.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.University of California, San Francisco, San Francisco, California, USA. San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.Morton and Gloria Shulman Movement Disorders Centre and Edmund J Saffra Program in Parkinson's Disease, Tornto Western Hospital, Toronto, Ontario, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28071824

Citation

Visanji, Naomi P., et al. "Heart Rate Variability in Leucine-rich Repeat Kinase 2-associated Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 32, no. 4, 2017, pp. 610-614.
Visanji NP, Bhudhikanok GS, Mestre TA, et al. Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease. Mov Disord. 2017;32(4):610-614.
Visanji, N. P., Bhudhikanok, G. S., Mestre, T. A., Ghate, T., Udupa, K., AlDakheel, A., ... Marras, C. (2017). Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 32(4), pp. 610-614. doi:10.1002/mds.26896.
Visanji NP, et al. Heart Rate Variability in Leucine-rich Repeat Kinase 2-associated Parkinson's Disease. Mov Disord. 2017;32(4):610-614. PubMed PMID: 28071824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease. AU - Visanji,Naomi P, AU - Bhudhikanok,Grace S, AU - Mestre,Tiago A, AU - Ghate,Taneera, AU - Udupa,Kaviraj, AU - AlDakheel,Amaal, AU - Connolly,Barbara S, AU - Gasca-Salas,Carmen, AU - Kern,Drew S, AU - Jain,Jennifer, AU - Slow,Elizabeth J, AU - Faust-Socher,Achinoam, AU - Kim,Sam, AU - Azhu Valappil,Ruksana, AU - Kausar,Farah, AU - Rogaeva,Ekaterina, AU - William Langston,J, AU - Tanner,Caroline M, AU - Schüle,Birgitt, AU - Lang,Anthony E, AU - Goldman,Samuel M, AU - Marras,Connie, Y1 - 2017/01/10/ PY - 2016/07/05/received PY - 2016/11/15/revised PY - 2016/11/20/accepted PY - 2017/1/11/pubmed PY - 2017/8/26/medline PY - 2017/1/11/entrez KW - LRRK2 KW - Parkinson's disease KW - autonomic dysfunction KW - heart rate variability SP - 610 EP - 614 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 32 IS - 4 N2 - BACKGROUND: Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD. OBJECTIVES: This study investigated heart rate variability in LRRK2-associated PD. METHODS: Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls. Linear regression modelling compared time and frequency domain values, adjusting for age, sex, heart rate, and disease duration. RESULTS: Low-frequency power and the ratio of low-high frequency power were reduced in idiopathic PD versus controls (P < .008, P < .029 respectively). In contrast, individuals with LRRK2-associated PD were not statistically different from controls in any parameter measured. Furthermore, all parameters trended toward being higher in LRRK2-associated PD when compared with idiopathic PD. CONCLUSIONS: Heart rate variability may remain intact in LRRK2-associated PD, adding to a growing literature supporting clinical-pathologic differences between LRRK2-associated and idiopathic PD. © 2017 International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/28071824/Heart_rate_variability_in_leucine_rich_repeat_kinase_2_associated_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.26896 DB - PRIME DP - Unbound Medicine ER -