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High density scalp EEG in frontal lobe epilepsy.
Epilepsy Res 2017; 129:157-161ER

Abstract

PURPOSE

Localization of seizures in frontal lobe epilepsy using the 10-20 system scalp EEG is often challenging because neocortical seizure can spread rapidly, significant muscle artifact, and the suboptimal spatial resolution for seizure generators involving mesial frontal lobe cortex. Our aim in this study was to determine the value of visual interpretation of 76 channel high density EEG (hdEEG) monitoring (10-10 system) in patients with suspected frontal lobe epilepsy, and to evaluate concordance with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional EEG, and intracranial EEG (iEEG).

METHODS

We performed a retrospective cohort study of 14 consecutive patients who underwent hdEEG monitoring for suspected frontal lobe seizures. The gold standard for localization was considered to be iEEG. Concordance of hdEEG findings with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional 10-20 EEG, and iEEG as well as correlation of hdEEG localization with surgical outcome were examined.

RESULTS

hdEEG localization was concordant with iEEG in 12/14 and was superior to conventional EEG 3/14 (p<0.01) and SISCOM 3/12 (p<0.01). hdEEG correctly lateralized seizure onset in 14/14 cases, compared to 9/14 (p=0.04) cases with conventional EEG. Seven patients underwent surgical resection, of whom five were seizure free.

CONCLUSIONS

hdEEG monitoring should be considered in patients with suspected frontal epilepsy requiring localization of epileptogenic brain. hdEEG may assist in developing a hypothesis for iEEG monitoring and could potentially augment EEG source localization.

Authors+Show Affiliations

Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, United States. Electronic address: Feyissa.Anteneh@mayo.edu.Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States. Electronic address: Britton.Jeffrey@mayo.edu.Departments of Neurological Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States. Electronic address: vangompel.jamie@mayo.edu.Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States. Electronic address: lagerlund.terrence@mayo.edu.Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States. Electronic address: eso@mayo.edu.Division of Child and Adolescent Neurology, Mayo Clinic Children's Center, 200 First Street SW, Rochester, MN, 55905, United States. Electronic address: WongKisiel.Lily@mayo.edu.Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States. Electronic address: gcascino@mayo.edu.Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States. Electronic address: Brinkmann.Benjamin@mayo.edu.Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States. Electronic address: Nelson.Cindy@mayo.edu.Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States. Electronic address: watson.robert16@mayo.edu.Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, United States. Electronic address: Worrell.Gregory@mayo.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28073096

Citation

Feyissa, Anteneh M., et al. "High Density Scalp EEG in Frontal Lobe Epilepsy." Epilepsy Research, vol. 129, 2017, pp. 157-161.
Feyissa AM, Britton JW, Van Gompel J, et al. High density scalp EEG in frontal lobe epilepsy. Epilepsy Res. 2017;129:157-161.
Feyissa, A. M., Britton, J. W., Van Gompel, J., Lagerlund, T. L., So, E., Wong-Kisiel, L. C., ... Worrell, G. A. (2017). High density scalp EEG in frontal lobe epilepsy. Epilepsy Research, 129, pp. 157-161. doi:10.1016/j.eplepsyres.2016.12.016.
Feyissa AM, et al. High Density Scalp EEG in Frontal Lobe Epilepsy. Epilepsy Res. 2017;129:157-161. PubMed PMID: 28073096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High density scalp EEG in frontal lobe epilepsy. AU - Feyissa,Anteneh M, AU - Britton,Jeffrey W, AU - Van Gompel,Jamie, AU - Lagerlund,Terrance L, AU - So,Elson, AU - Wong-Kisiel,Lilly C, AU - Cascino,Gregory C, AU - Brinkman,Benjamin H, AU - Nelson,Cindy L, AU - Watson,Robert, AU - Worrell,Gregory A, Y1 - 2017/01/02/ PY - 2016/07/31/received PY - 2016/12/27/revised PY - 2016/12/31/accepted PY - 2017/1/11/pubmed PY - 2018/1/4/medline PY - 2017/1/11/entrez KW - Drug resistant epilepsy KW - Epilepsy surgery KW - Frontal lobe epilepsy KW - High density EEG KW - Midline and parasagittal KW - SISCOM KW - Source localization SP - 157 EP - 161 JF - Epilepsy research JO - Epilepsy Res. VL - 129 N2 - PURPOSE: Localization of seizures in frontal lobe epilepsy using the 10-20 system scalp EEG is often challenging because neocortical seizure can spread rapidly, significant muscle artifact, and the suboptimal spatial resolution for seizure generators involving mesial frontal lobe cortex. Our aim in this study was to determine the value of visual interpretation of 76 channel high density EEG (hdEEG) monitoring (10-10 system) in patients with suspected frontal lobe epilepsy, and to evaluate concordance with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional EEG, and intracranial EEG (iEEG). METHODS: We performed a retrospective cohort study of 14 consecutive patients who underwent hdEEG monitoring for suspected frontal lobe seizures. The gold standard for localization was considered to be iEEG. Concordance of hdEEG findings with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional 10-20 EEG, and iEEG as well as correlation of hdEEG localization with surgical outcome were examined. RESULTS: hdEEG localization was concordant with iEEG in 12/14 and was superior to conventional EEG 3/14 (p<0.01) and SISCOM 3/12 (p<0.01). hdEEG correctly lateralized seizure onset in 14/14 cases, compared to 9/14 (p=0.04) cases with conventional EEG. Seven patients underwent surgical resection, of whom five were seizure free. CONCLUSIONS: hdEEG monitoring should be considered in patients with suspected frontal epilepsy requiring localization of epileptogenic brain. hdEEG may assist in developing a hypothesis for iEEG monitoring and could potentially augment EEG source localization. SN - 1872-6844 UR - https://www.unboundmedicine.com/medline/citation/28073096/High_density_scalp_EEG_in_frontal_lobe_epilepsy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-1211(16)30415-6 DB - PRIME DP - Unbound Medicine ER -