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The Effect of Vitamin D on Thyroid Autoimmunity in Levothyroxine-Treated Women with Hashimoto's Thyroiditis and Normal Vitamin D Status.
Exp Clin Endocrinol Diabetes 2017; 125(4):229-233EC

Abstract

Background:

Low vitamin D status is associated with autoimmune thyroid disease. Oral vitamin D supplementation was found to reduce titers of thyroid antibodies in levothyroxine-treated women with postpartum thyroiditis and low vitamin D status.

Methods:

The study included 34 women with Hashimoto's thyroiditis and normal vitamin D status (serum 25-hydroxyvitamin D levels above 30 ng/mL) who had been treated for at least 6 months with levothyroxine. On the basis of patient preference, women were divided into 2 groups, receiving (n=18) or not receiving (n=16) oral vitamin D preparations (2000 IU daily). Serum levels of thyrotropin, free thyroxine, free triiodothyronine and 25-hydroxyvitamin D, as well as titers of thyroid peroxidase and thyroglobulin antibodies were measured at the beginning of the study and 6 months later.

Results:

There were no significant differences in baseline values between both study groups. 25-hydroxyvitamin D levels inversely correlated with titers of thyroid antibodies. No changes in hypothalamic-pituitary-thyroid axis activity and thyroid antibody titers were observed in vitamin-naïve patients. Vitamin D increased serum levels of 25-hydroxyvitamin D, as well as reduced titers of thyroid antibodies. This effect was more pronounced for thyroid peroxidase than for thyroglobulin antibodies and correlated with their baseline titers.

Conclusions:

Vitamin D preparations may reduce thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and normal vitamin D status.

Authors+Show Affiliations

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

28073128

Citation

Krysiak, Robert, et al. "The Effect of Vitamin D On Thyroid Autoimmunity in Levothyroxine-Treated Women With Hashimoto's Thyroiditis and Normal Vitamin D Status." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 125, no. 4, 2017, pp. 229-233.
Krysiak R, Szkróbka W, Okopień B. The Effect of Vitamin D on Thyroid Autoimmunity in Levothyroxine-Treated Women with Hashimoto's Thyroiditis and Normal Vitamin D Status. Exp Clin Endocrinol Diabetes. 2017;125(4):229-233.
Krysiak, R., Szkróbka, W., & Okopień, B. (2017). The Effect of Vitamin D on Thyroid Autoimmunity in Levothyroxine-Treated Women with Hashimoto's Thyroiditis and Normal Vitamin D Status. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 125(4), pp. 229-233. doi:10.1055/s-0042-123038.
Krysiak R, Szkróbka W, Okopień B. The Effect of Vitamin D On Thyroid Autoimmunity in Levothyroxine-Treated Women With Hashimoto's Thyroiditis and Normal Vitamin D Status. Exp Clin Endocrinol Diabetes. 2017;125(4):229-233. PubMed PMID: 28073128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of Vitamin D on Thyroid Autoimmunity in Levothyroxine-Treated Women with Hashimoto's Thyroiditis and Normal Vitamin D Status. AU - Krysiak,Robert, AU - Szkróbka,Witold, AU - Okopień,Bogusław, Y1 - 2017/01/10/ PY - 2017/1/11/pubmed PY - 2017/12/30/medline PY - 2017/1/11/entrez SP - 229 EP - 233 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp. Clin. Endocrinol. Diabetes VL - 125 IS - 4 N2 - Background: Low vitamin D status is associated with autoimmune thyroid disease. Oral vitamin D supplementation was found to reduce titers of thyroid antibodies in levothyroxine-treated women with postpartum thyroiditis and low vitamin D status. Methods: The study included 34 women with Hashimoto's thyroiditis and normal vitamin D status (serum 25-hydroxyvitamin D levels above 30 ng/mL) who had been treated for at least 6 months with levothyroxine. On the basis of patient preference, women were divided into 2 groups, receiving (n=18) or not receiving (n=16) oral vitamin D preparations (2000 IU daily). Serum levels of thyrotropin, free thyroxine, free triiodothyronine and 25-hydroxyvitamin D, as well as titers of thyroid peroxidase and thyroglobulin antibodies were measured at the beginning of the study and 6 months later. Results: There were no significant differences in baseline values between both study groups. 25-hydroxyvitamin D levels inversely correlated with titers of thyroid antibodies. No changes in hypothalamic-pituitary-thyroid axis activity and thyroid antibody titers were observed in vitamin-naïve patients. Vitamin D increased serum levels of 25-hydroxyvitamin D, as well as reduced titers of thyroid antibodies. This effect was more pronounced for thyroid peroxidase than for thyroglobulin antibodies and correlated with their baseline titers. Conclusions: Vitamin D preparations may reduce thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and normal vitamin D status. SN - 1439-3646 UR - https://www.unboundmedicine.com/medline/citation/28073128/The_Effect_of_Vitamin_D_on_Thyroid_Autoimmunity_in_Levothyroxine_Treated_Women_with_Hashimoto's_Thyroiditis_and_Normal_Vitamin_D_Status_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0042-123038 DB - PRIME DP - Unbound Medicine ER -