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Trans-Fatty Acid-Stimulated Mammary Gland Growth in Ovariectomized Mice is Fatty Acid Type and Isomer Specific.
Lipids. 2017 03; 52(3):223-233.L

Abstract

We previously reported that the trans-18:2 fatty acid trans-10, cis-12 conjugated linoleic acid (t10,c12-CLA) stimulates mammary gland development independent of estrogen and its receptor. Given the negative consequences of dietary trans-fatty acids on various aspects of human health, we sought to establish whether other trans-fatty acids could similarly induce ovary-independent mammary gland growth in mice. Prepubertal BALB/cJ mice were ovariectomized at 21 days of age then were fed diets enriched with cis-9, trans-11 CLA (c9,t11-CLA), or mixtures of trans-18:1 fatty acids supplied by partially hydrogenated sunflower, safflower, or linseed oil. The resultant mammary phenotype was evaluated 3 weeks later and compared to the growth response elicited by t10,c12-CLA, or the defined control diet. Whereas partially hydrogenated safflower oil increased mammary gland weight, none of the partially hydrogenated vegetable oils promoted mammary ductal growth. Similarly, the c9,t11-CLA supplemented diet was without effect on mammary development. Taken together, our data emphasize a unique effect of t10,c12-CLA in stimulating estrogen-independent mammary gland growth manifest as increased mammary ductal area and elongation that was not recapitulated by c9,t11-CLA or the partially hydrogenated vegetable oil diets.

Authors+Show Affiliations

Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, CA, 95616-8521, USA.Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, CA, 95616-8521, USA.Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, CA, 95616-8521, USA.Department of Animal and Veterinary Science, University of Vermont, 570 Main St., Burlington, VT, 05405-0148, USA.Department of Animal Science, Michigan State University, 474 S. Shaw Lane, East Lansing, MI, 48824-1225, USA.Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, CA, 95616-8521, USA. rchovey@ucdavis.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28074319

Citation

Berryhill, Grace E., et al. "Trans-Fatty Acid-Stimulated Mammary Gland Growth in Ovariectomized Mice Is Fatty Acid Type and Isomer Specific." Lipids, vol. 52, no. 3, 2017, pp. 223-233.
Berryhill GE, Miszewski SG, Trott JF, et al. Trans-Fatty Acid-Stimulated Mammary Gland Growth in Ovariectomized Mice is Fatty Acid Type and Isomer Specific. Lipids. 2017;52(3):223-233.
Berryhill, G. E., Miszewski, S. G., Trott, J. F., Kraft, J., Lock, A. L., & Hovey, R. C. (2017). Trans-Fatty Acid-Stimulated Mammary Gland Growth in Ovariectomized Mice is Fatty Acid Type and Isomer Specific. Lipids, 52(3), 223-233. https://doi.org/10.1007/s11745-016-4221-2
Berryhill GE, et al. Trans-Fatty Acid-Stimulated Mammary Gland Growth in Ovariectomized Mice Is Fatty Acid Type and Isomer Specific. Lipids. 2017;52(3):223-233. PubMed PMID: 28074319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trans-Fatty Acid-Stimulated Mammary Gland Growth in Ovariectomized Mice is Fatty Acid Type and Isomer Specific. AU - Berryhill,Grace E, AU - Miszewski,Susan G, AU - Trott,Josephine F, AU - Kraft,Jana, AU - Lock,Adam L, AU - Hovey,Russell C, Y1 - 2017/01/10/ PY - 2016/06/13/received PY - 2016/12/02/accepted PY - 2017/1/12/pubmed PY - 2017/7/22/medline PY - 2017/1/12/entrez KW - Conjugated linoleic acid KW - Mammary gland KW - Partially hydrogenated vegetable oil KW - Trans-fatty acids SP - 223 EP - 233 JF - Lipids JO - Lipids VL - 52 IS - 3 N2 - We previously reported that the trans-18:2 fatty acid trans-10, cis-12 conjugated linoleic acid (t10,c12-CLA) stimulates mammary gland development independent of estrogen and its receptor. Given the negative consequences of dietary trans-fatty acids on various aspects of human health, we sought to establish whether other trans-fatty acids could similarly induce ovary-independent mammary gland growth in mice. Prepubertal BALB/cJ mice were ovariectomized at 21 days of age then were fed diets enriched with cis-9, trans-11 CLA (c9,t11-CLA), or mixtures of trans-18:1 fatty acids supplied by partially hydrogenated sunflower, safflower, or linseed oil. The resultant mammary phenotype was evaluated 3 weeks later and compared to the growth response elicited by t10,c12-CLA, or the defined control diet. Whereas partially hydrogenated safflower oil increased mammary gland weight, none of the partially hydrogenated vegetable oils promoted mammary ductal growth. Similarly, the c9,t11-CLA supplemented diet was without effect on mammary development. Taken together, our data emphasize a unique effect of t10,c12-CLA in stimulating estrogen-independent mammary gland growth manifest as increased mammary ductal area and elongation that was not recapitulated by c9,t11-CLA or the partially hydrogenated vegetable oil diets. SN - 1558-9307 UR - https://www.unboundmedicine.com/medline/citation/28074319/Trans_Fatty_Acid_Stimulated_Mammary_Gland_Growth_in_Ovariectomized_Mice_is_Fatty_Acid_Type_and_Isomer_Specific_ L2 - https://link.springer.com/article/10.1007/s11745-016-4221-2 DB - PRIME DP - Unbound Medicine ER -