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[Normoglycaemic ketoacidosis in pregnant patients with diabetes; early recognition is critical].
Ned Tijdschr Geneeskd. 2016; 160:D551.NT

Abstract

Diabetic ketoacidosis (DKA) during pregnancy is a rare but very serious complication that requires early recognition and treatment to prevent severe complications. Here we present three cases in which DKA occurred during normoglycaemia, demonstrating the importance of early recognition. In pregnancy, DKA can occur at lower blood glucose levels than usual due to several pregnancy-related factors, such as altered metabolism, increased insulin resistance, lower buffering capacity related to chronic hyperventilation and hunger. Symptoms that are common during pregnancy, such as vomiting, may be missed as a first sign of DKA. In patients with type 1 diabetes mellitus (especially those on continuous subcutaneous insulin infusion) insulin administration must never be discontinued, as this prevents lipolysis and ketone formation. Physicians and patients need to be aware of the risks and management of DKA in pregnancy.

Authors+Show Affiliations

Amphia Ziekenhuis, Breda.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

dut

PubMed ID

28074733

Citation

van der Valk, E S., et al. "[Normoglycaemic Ketoacidosis in Pregnant Patients With Diabetes; Early Recognition Is Critical]." Nederlands Tijdschrift Voor Geneeskunde, vol. 160, 2016, p. D551.
van der Valk ES, Smits M, Klomp CM, et al. [Normoglycaemic ketoacidosis in pregnant patients with diabetes; early recognition is critical]. Ned Tijdschr Geneeskd. 2016;160:D551.
van der Valk, E. S., Smits, M., Klomp, C. M., Lunshof, M. S., van Guldener, C., & van Thiel, S. W. (2016). [Normoglycaemic ketoacidosis in pregnant patients with diabetes; early recognition is critical]. Nederlands Tijdschrift Voor Geneeskunde, 160, D551.
van der Valk ES, et al. [Normoglycaemic Ketoacidosis in Pregnant Patients With Diabetes; Early Recognition Is Critical]. Ned Tijdschr Geneeskd. 2016;160:D551. PubMed PMID: 28074733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Normoglycaemic ketoacidosis in pregnant patients with diabetes; early recognition is critical]. AU - van der Valk,E S, AU - Smits,M, AU - Klomp,C M C, AU - Lunshof,M S, AU - van Guldener,C, AU - van Thiel,S W, PY - 2017/1/12/entrez PY - 2017/1/12/pubmed PY - 2018/2/10/medline SP - D551 EP - D551 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 160 N2 - Diabetic ketoacidosis (DKA) during pregnancy is a rare but very serious complication that requires early recognition and treatment to prevent severe complications. Here we present three cases in which DKA occurred during normoglycaemia, demonstrating the importance of early recognition. In pregnancy, DKA can occur at lower blood glucose levels than usual due to several pregnancy-related factors, such as altered metabolism, increased insulin resistance, lower buffering capacity related to chronic hyperventilation and hunger. Symptoms that are common during pregnancy, such as vomiting, may be missed as a first sign of DKA. In patients with type 1 diabetes mellitus (especially those on continuous subcutaneous insulin infusion) insulin administration must never be discontinued, as this prevents lipolysis and ketone formation. Physicians and patients need to be aware of the risks and management of DKA in pregnancy. SN - 1876-8784 UR - https://www.unboundmedicine.com/medline/citation/28074733/[Normoglycaemic_ketoacidosis_in_pregnant_patients_with_diabetes L2 - http://www.ntvg.nl/D551 DB - PRIME DP - Unbound Medicine ER -