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Can Stoss Therapy Be Used in Children with Vitamin D Deficiency or Insufficiency without Rickets?
J Clin Res Pediatr Endocrinol 2017; 9(2):150-155JC

Abstract

OBJECTIVE

Stoss vitamin D treatment has been recommended for its non-skeletal benefits in adults, but there is a lack of data on the optimal dose of vitamin D stoss therapy in children with vitamin D deficiency/insufficiency without rickets. This study aimed to compare efficiency/side effects of two different stoss therapy regimens (10 000 IU/kg and 300 000 IU vitamin D3) administered in children with vitamin D deficiency/insufficiency without rickets.

METHODS

Sixty-four children who had vitamin D deficiency/insufficiency were studied. A serum 25-hydroxyvitamin-D (25-OH-D) level of 15-20 ng/mL was considered as vitamin D insufficient and <15 ng/mL was considered as vitamin D deficient. The patients were divided into two groups according to the stoss therapy doses they received. Serum calcium, phosphate, alkaline phosphatase, 25-OH-D, parathyroid hormone levels, and spot urine calcium/creatinine ratios before/after treatment were recorded. Wrist radiography and renal ultrasonography were performed.

RESULTS

The mean age of the subjects was 10.6±4.4 years. Thirty-two children were treated with a single vitamin D3 dose of 10 000 IU/kg and 32 patients received 300 000 IU. No difference was found in 25-OH-D levels between the two groups at presentation. The mean level of 25-OH-D was higher in the 10 000 IU/kg group at the second week of therapy. There was no difference between the groups at post-treatment weeks 4 and 12. The 25-OH-D was found to be below optimal levels (≥30 ng/mL) in 66.5% and <20 ng/mL in 21.8% of patients at the third month in both groups. None developed hypercalcemia and/or hypercalciuria. Nephrolithiasis was not detected in any patient.

CONCLUSION

This study showed that both doses of stoss therapy used in the treatment of vitamin D insufficiency/deficiency are effective and safe. However, an optimal level of 25-OH-D cannot be maintained for more than three months.

Authors+Show Affiliations

İzmir Katip Çelebi University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, Turkey, E-mail: dr.cmlkcygt@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28077342

Citation

Koçyiğit, Cemil, et al. "Can Stoss Therapy Be Used in Children With Vitamin D Deficiency or Insufficiency Without Rickets?" Journal of Clinical Research in Pediatric Endocrinology, vol. 9, no. 2, 2017, pp. 150-155.
Koçyiğit C, Çatlı G, İnce G, et al. Can Stoss Therapy Be Used in Children with Vitamin D Deficiency or Insufficiency without Rickets? J Clin Res Pediatr Endocrinol. 2017;9(2):150-155.
Koçyiğit, C., Çatlı, G., İnce, G., Özkan, E. B., & Dündar, B. N. (2017). Can Stoss Therapy Be Used in Children with Vitamin D Deficiency or Insufficiency without Rickets? Journal of Clinical Research in Pediatric Endocrinology, 9(2), pp. 150-155. doi:10.4274/jcrpe.3842.
Koçyiğit C, et al. Can Stoss Therapy Be Used in Children With Vitamin D Deficiency or Insufficiency Without Rickets. J Clin Res Pediatr Endocrinol. 2017 Jun 1;9(2):150-155. PubMed PMID: 28077342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can Stoss Therapy Be Used in Children with Vitamin D Deficiency or Insufficiency without Rickets? AU - Koçyiğit,Cemil, AU - Çatlı,Gönül, AU - İnce,Gülberat, AU - Özkan,Elif Büşra, AU - Dündar,Bumin Nuri, Y1 - 2017/01/12/ PY - 2017/1/13/pubmed PY - 2018/3/20/medline PY - 2017/1/13/entrez KW - Vitamin D deficiency KW - rickets stoss therapy. SP - 150 EP - 155 JF - Journal of clinical research in pediatric endocrinology JO - J Clin Res Pediatr Endocrinol VL - 9 IS - 2 N2 - OBJECTIVE: Stoss vitamin D treatment has been recommended for its non-skeletal benefits in adults, but there is a lack of data on the optimal dose of vitamin D stoss therapy in children with vitamin D deficiency/insufficiency without rickets. This study aimed to compare efficiency/side effects of two different stoss therapy regimens (10 000 IU/kg and 300 000 IU vitamin D3) administered in children with vitamin D deficiency/insufficiency without rickets. METHODS: Sixty-four children who had vitamin D deficiency/insufficiency were studied. A serum 25-hydroxyvitamin-D (25-OH-D) level of 15-20 ng/mL was considered as vitamin D insufficient and <15 ng/mL was considered as vitamin D deficient. The patients were divided into two groups according to the stoss therapy doses they received. Serum calcium, phosphate, alkaline phosphatase, 25-OH-D, parathyroid hormone levels, and spot urine calcium/creatinine ratios before/after treatment were recorded. Wrist radiography and renal ultrasonography were performed. RESULTS: The mean age of the subjects was 10.6±4.4 years. Thirty-two children were treated with a single vitamin D3 dose of 10 000 IU/kg and 32 patients received 300 000 IU. No difference was found in 25-OH-D levels between the two groups at presentation. The mean level of 25-OH-D was higher in the 10 000 IU/kg group at the second week of therapy. There was no difference between the groups at post-treatment weeks 4 and 12. The 25-OH-D was found to be below optimal levels (≥30 ng/mL) in 66.5% and <20 ng/mL in 21.8% of patients at the third month in both groups. None developed hypercalcemia and/or hypercalciuria. Nephrolithiasis was not detected in any patient. CONCLUSION: This study showed that both doses of stoss therapy used in the treatment of vitamin D insufficiency/deficiency are effective and safe. However, an optimal level of 25-OH-D cannot be maintained for more than three months. SN - 1308-5735 UR - https://www.unboundmedicine.com/medline/citation/28077342/Can_Stoss_Therapy_Be_Used_in_Children_with_Vitamin_D_Deficiency_or_Insufficiency_without_Rickets L2 - https://doi.org/10.4274/jcrpe.3842 DB - PRIME DP - Unbound Medicine ER -