Tags

Type your tag names separated by a space and hit enter

Cutaneous Larva Migrans.

Abstract

BACKGROUND

Cutaneous larva migrans is one of the most common skin diseases reported in travelers returning from tropical regions. Western physicians, however, are often not familiar of this condition.

OBJECTIVE

To review in depth the epidemiology, pathophysiology, clinical manifestations, complications, and treatment of cutaneous larva migrans.

METHODS

A PubMed search was completed in Clinical Queries using the key term "cutaneous larva migrans". The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. Patents were searched using the key term "cutaneous larva migrans" from www.google.com/patents, www.uspto.gov, and www.freepatentsonline.com.

RESULTS

Cutaneous larva migrans is a zoonotic infestation caused by penetration and migration in the epidermis of filariform larva of different kinds of animal hookworms through contact with feces of infected animals. Cutaneous larva migrans is endemic in tropical and subtropical regions. Clinically, cutaneous larva migrans is characterized by an intensely pruritic erythematous migrating tortuous or serpiginous, slightly raised track. The diagnosis is mainly clinical, based on the history of travel to an endemic area and exposure to contaminated soil/sand and the characteristic serpiginous track. Treatment options as well as recent patents related to the management of cutaneous larva migrans are also discussed. Compared with oral antihelminthics, topical treatment over the affected area is less effective. Oral ivermectin is the treatment of choice.

CONCLUSION

The pruritic serpiginous track is pathognomonic. Oral ivermectin is the treatment of choice.

Authors+Show Affiliations

The University of Calgary, Alberta Children's Hospital, #200, 233 - 16th Avenue NW, Calgary, Alberta. Canada.Toronto Dermatology Centre, Toronto, Ontario. Canada.Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28078983

Citation

Leung, Alexander K C., et al. "Cutaneous Larva Migrans." Recent Patents On Inflammation & Allergy Drug Discovery, vol. 11, no. 1, 2017, pp. 2-11.
Leung AKC, Barankin B, Hon KLE. Cutaneous Larva Migrans. Recent Pat Inflamm Allergy Drug Discov. 2017;11(1):2-11.
Leung, A. K. C., Barankin, B., & Hon, K. L. E. (2017). Cutaneous Larva Migrans. Recent Patents On Inflammation & Allergy Drug Discovery, 11(1), 2-11. https://doi.org/10.2174/1872213X11666170110162344
Leung AKC, Barankin B, Hon KLE. Cutaneous Larva Migrans. Recent Pat Inflamm Allergy Drug Discov. 2017;11(1):2-11. PubMed PMID: 28078983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous Larva Migrans. AU - Leung,Alexander K C, AU - Barankin,Benjamin, AU - Hon,Kam L E, PY - 2016/12/20/received PY - 2017/01/09/revised PY - 2017/01/09/accepted PY - 2017/1/13/pubmed PY - 2017/11/29/medline PY - 2017/1/13/entrez KW - Ancylostoma braziliense KW - Ancylostoma caninum KW - cats KW - dogs KW - hookworm KW - pruritus KW - serpiginous track SP - 2 EP - 11 JF - Recent patents on inflammation & allergy drug discovery JO - Recent Pat Inflamm Allergy Drug Discov VL - 11 IS - 1 N2 - BACKGROUND: Cutaneous larva migrans is one of the most common skin diseases reported in travelers returning from tropical regions. Western physicians, however, are often not familiar of this condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications, and treatment of cutaneous larva migrans. METHODS: A PubMed search was completed in Clinical Queries using the key term "cutaneous larva migrans". The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. Patents were searched using the key term "cutaneous larva migrans" from www.google.com/patents, www.uspto.gov, and www.freepatentsonline.com. RESULTS: Cutaneous larva migrans is a zoonotic infestation caused by penetration and migration in the epidermis of filariform larva of different kinds of animal hookworms through contact with feces of infected animals. Cutaneous larva migrans is endemic in tropical and subtropical regions. Clinically, cutaneous larva migrans is characterized by an intensely pruritic erythematous migrating tortuous or serpiginous, slightly raised track. The diagnosis is mainly clinical, based on the history of travel to an endemic area and exposure to contaminated soil/sand and the characteristic serpiginous track. Treatment options as well as recent patents related to the management of cutaneous larva migrans are also discussed. Compared with oral antihelminthics, topical treatment over the affected area is less effective. Oral ivermectin is the treatment of choice. CONCLUSION: The pruritic serpiginous track is pathognomonic. Oral ivermectin is the treatment of choice. SN - 1872-213X UR - https://www.unboundmedicine.com/medline/citation/28078983/Cutaneous_Larva_Migrans_ DB - PRIME DP - Unbound Medicine ER -