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An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study.
Metabolism. 2017 Feb; 67:54-61.M

Abstract

OBJECTIVE

Although metabolic abnormalities have been considered important risk factors of chronic kidney disease (CKD), the impact of metabolic syndrome (MS) and insulin resistance on renal function deterioration is poorly understood. We investigated the association between MS and incident CKD/rapid decline of estimated glomerular filtration rate (eGFR) in a 10-year population-based longitudinal study.

MATERIAL AND METHODS

Among 10,030 subjects, 6065 without history of CKD or cardiovascular disease at baseline were analyzed using data generated from the Ansan-Ansung cohort of the Korean Genome Epidemiology Study. Participants were categorized into two groups based on the presence of MS at baseline. Incident CKD was defined as eGFR <60ml/min per 1.73m2, and rapid decline of eGFR was defined as >3ml/min per 1.73m2/yr over 10years.

RESULTS

During the 10-year follow-up period, CKD developed in 893 subjects (14.7%). Compared to subjects without MS, the odds ratio (OR; 95% confidence interval, CI) of incident CKD in those with MS was 1.38 (1.16-1.64) after controlling for confounding factors. The risk of rapid decline of eGFR was also higher in subjects with MS than those without MS (OR: 1.20, 95% CI: 1.04-1.39). In addition, we found that higher levels of homeostatic model assessment of insulin resistance (HOMA-IR) were associated with incident CKD and rapid decline of eGFR independently of traditional CKD risk factors (OR: 1.24, 95% CI: 1.04-1.47).

CONCLUSION

Both MS and insulin resistance were independent risk factors of incident CKD and rapid decline of eGFR in healthy Korean population.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea.Department of Preventive Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea.Division of Nephrology, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea.Division of Cardiology, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea.Institute of Life Style Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea,. Electronic address: eunhee_choi@yonsei.ac.kr.Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Gyeonggi, South Korea.Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Gyeonggi, South Korea.Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.Division of Cardiology, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Republic of Korea,. Electronic address: kimjang713@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28081778

Citation

Huh, Ji Hye, et al. "An Association of Metabolic Syndrome and Chronic Kidney Disease From a 10-year Prospective Cohort Study." Metabolism: Clinical and Experimental, vol. 67, 2017, pp. 54-61.
Huh JH, Yadav D, Kim JS, et al. An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study. Metabolism. 2017;67:54-61.
Huh, J. H., Yadav, D., Kim, J. S., Son, J. W., Choi, E., Kim, S. H., Shin, C., Sung, K. C., & Kim, J. Y. (2017). An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study. Metabolism: Clinical and Experimental, 67, 54-61. https://doi.org/10.1016/j.metabol.2016.11.003
Huh JH, et al. An Association of Metabolic Syndrome and Chronic Kidney Disease From a 10-year Prospective Cohort Study. Metabolism. 2017;67:54-61. PubMed PMID: 28081778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study. AU - Huh,Ji Hye, AU - Yadav,Dhananjay, AU - Kim,Jae Seok, AU - Son,Jung-Woo, AU - Choi,Eunhee, AU - Kim,Seong Hwan, AU - Shin,Chol, AU - Sung,Ki-Chul, AU - Kim,Jang Young, Y1 - 2016/11/06/ PY - 2016/07/08/received PY - 2016/10/03/revised PY - 2016/11/02/accepted PY - 2017/1/14/entrez PY - 2017/1/14/pubmed PY - 2017/5/23/medline KW - Chronic kidney disease KW - Insulin resistance KW - Metabolic syndrome KW - Rapid decline of GFR SP - 54 EP - 61 JF - Metabolism: clinical and experimental JO - Metabolism VL - 67 N2 - OBJECTIVE: Although metabolic abnormalities have been considered important risk factors of chronic kidney disease (CKD), the impact of metabolic syndrome (MS) and insulin resistance on renal function deterioration is poorly understood. We investigated the association between MS and incident CKD/rapid decline of estimated glomerular filtration rate (eGFR) in a 10-year population-based longitudinal study. MATERIAL AND METHODS: Among 10,030 subjects, 6065 without history of CKD or cardiovascular disease at baseline were analyzed using data generated from the Ansan-Ansung cohort of the Korean Genome Epidemiology Study. Participants were categorized into two groups based on the presence of MS at baseline. Incident CKD was defined as eGFR <60ml/min per 1.73m2, and rapid decline of eGFR was defined as >3ml/min per 1.73m2/yr over 10years. RESULTS: During the 10-year follow-up period, CKD developed in 893 subjects (14.7%). Compared to subjects without MS, the odds ratio (OR; 95% confidence interval, CI) of incident CKD in those with MS was 1.38 (1.16-1.64) after controlling for confounding factors. The risk of rapid decline of eGFR was also higher in subjects with MS than those without MS (OR: 1.20, 95% CI: 1.04-1.39). In addition, we found that higher levels of homeostatic model assessment of insulin resistance (HOMA-IR) were associated with incident CKD and rapid decline of eGFR independently of traditional CKD risk factors (OR: 1.24, 95% CI: 1.04-1.47). CONCLUSION: Both MS and insulin resistance were independent risk factors of incident CKD and rapid decline of eGFR in healthy Korean population. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/28081778/An_association_of_metabolic_syndrome_and_chronic_kidney_disease_from_a_10_year_prospective_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(16)30149-4 DB - PRIME DP - Unbound Medicine ER -