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Exposure to famine in early life and the risk of obesity in adulthood in Qingdao: Evidence from the 1959-1961 Chinese famine.
Nutr Metab Cardiovasc Dis 2017; 27(2):154-160NM

Abstract

BACKGROUND AND AIMS

We aimed to evaluate the association between famine exposure during early life and obesity and obesitymax (obese at the highest weight) in adulthood.

METHODS AND RESULTS

Data were from two population-based cross-sectional surveys conducted in 2006 and 2009 in Qingdao, China. A total of 8185 subjects born between 1/1/1941 and 12/31/1971 were categorized into unexposed (born between 01/01/1962 and 12/31/1971), fetal/infant exposed (born between 01/01/1959 and 12/31/1961), childhood exposed (born between 01/01/1949 and 12/31/1958) and adolescence exposed (born between 01/01/1941 and 12/31/1948) according to their age when exposed to the Chinese famine from 1959 to 1961. Obesity was defined as BMI (body mass index) ≥28.0 and obesitymax was defined as BMImax (BMI at the highest weight) ≥28.0. We compared fetal/infant exposed, childhood exposed and adolescence exposed to the unexposed using logistic regression models to assess the effect of famine exposure on later obesity and obesitymax. Fetal/infant exposed (OR = 1.59, P < 0.001), childhood exposed (OR = 1.42, P < 0.01) and adolescence exposed (OR = 1.86, P < 0.01) all had higher risks of obesity than the unexposed. Exposure groups were more likely to be obese at their highest weight than the unexposed, and ORs (95%CIs) for obesitymax in the fetal/infant exposed, childhood exposed and adolescence exposed were 1.49(1.20-1.86), 1.24(1.02-1.49) and 1.64 (1.40-1.93), respectively. Similar results were found in both men and women.

CONCLUSION

Exposure to famine in early life was associated with increased risks of obesity and obesitymax in adulthood. Preventing undernutrition in early life appears beneficial to reduce the prevalence of later obesity.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, Qingdao University Medical College, Qingdao 266021, Shandong Province, China; Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, Shandong Province, China.Department of Nutrition and Food Hygiene, Qingdao University Medical College, Qingdao 266021, Shandong Province, China; Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, Shandong Province, China. Electronic address: 15726227711@163.com.Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, Shandong Province, China.Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, Shandong Province, China.Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, Shandong Province, China.Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, Shandong Province, China.Department of Public Health, University of Helsinki, Helsinki 00014, Finland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28081988

Citation

Liu, L, et al. "Exposure to Famine in Early Life and the Risk of Obesity in Adulthood in Qingdao: Evidence From the 1959-1961 Chinese Famine." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 27, no. 2, 2017, pp. 154-160.
Liu L, Pang ZC, Sun JP, et al. Exposure to famine in early life and the risk of obesity in adulthood in Qingdao: Evidence from the 1959-1961 Chinese famine. Nutr Metab Cardiovasc Dis. 2017;27(2):154-160.
Liu, L., Pang, Z. C., Sun, J. P., Xue, B., Wang, S. J., Ning, F., & Qiao, Q. (2017). Exposure to famine in early life and the risk of obesity in adulthood in Qingdao: Evidence from the 1959-1961 Chinese famine. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 27(2), pp. 154-160. doi:10.1016/j.numecd.2016.11.125.
Liu L, et al. Exposure to Famine in Early Life and the Risk of Obesity in Adulthood in Qingdao: Evidence From the 1959-1961 Chinese Famine. Nutr Metab Cardiovasc Dis. 2017;27(2):154-160. PubMed PMID: 28081988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to famine in early life and the risk of obesity in adulthood in Qingdao: Evidence from the 1959-1961 Chinese famine. AU - Liu,L, AU - Pang,Z C, AU - Sun,J P, AU - Xue,B, AU - Wang,S J, AU - Ning,F, AU - Qiao,Q, Y1 - 2016/12/05/ PY - 2016/09/08/received PY - 2016/11/26/revised PY - 2016/11/29/accepted PY - 2017/1/14/pubmed PY - 2017/8/30/medline PY - 2017/1/14/entrez KW - Adulthood KW - Early life KW - Famine exposure KW - Obesity SP - 154 EP - 160 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 27 IS - 2 N2 - BACKGROUND AND AIMS: We aimed to evaluate the association between famine exposure during early life and obesity and obesitymax (obese at the highest weight) in adulthood. METHODS AND RESULTS: Data were from two population-based cross-sectional surveys conducted in 2006 and 2009 in Qingdao, China. A total of 8185 subjects born between 1/1/1941 and 12/31/1971 were categorized into unexposed (born between 01/01/1962 and 12/31/1971), fetal/infant exposed (born between 01/01/1959 and 12/31/1961), childhood exposed (born between 01/01/1949 and 12/31/1958) and adolescence exposed (born between 01/01/1941 and 12/31/1948) according to their age when exposed to the Chinese famine from 1959 to 1961. Obesity was defined as BMI (body mass index) ≥28.0 and obesitymax was defined as BMImax (BMI at the highest weight) ≥28.0. We compared fetal/infant exposed, childhood exposed and adolescence exposed to the unexposed using logistic regression models to assess the effect of famine exposure on later obesity and obesitymax. Fetal/infant exposed (OR = 1.59, P < 0.001), childhood exposed (OR = 1.42, P < 0.01) and adolescence exposed (OR = 1.86, P < 0.01) all had higher risks of obesity than the unexposed. Exposure groups were more likely to be obese at their highest weight than the unexposed, and ORs (95%CIs) for obesitymax in the fetal/infant exposed, childhood exposed and adolescence exposed were 1.49(1.20-1.86), 1.24(1.02-1.49) and 1.64 (1.40-1.93), respectively. Similar results were found in both men and women. CONCLUSION: Exposure to famine in early life was associated with increased risks of obesity and obesitymax in adulthood. Preventing undernutrition in early life appears beneficial to reduce the prevalence of later obesity. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/28081988/Exposure_to_famine_in_early_life_and_the_risk_of_obesity_in_adulthood_in_Qingdao:_Evidence_from_the_1959_1961_Chinese_famine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(16)30330-1 DB - PRIME DP - Unbound Medicine ER -