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The growth-inhibitory properties of meropenem against anaerobes of clinical importance.
J Antimicrob Chemother. 1989 Sep; 24 Suppl A:119-24.JA

Abstract

The in-vitro activity of meropenem against anaerobic bacteria was assessed by an agar dilution procedure. MICs were measured for 449 clinical isolates and reference strains. Meropenem showed excellent activity against both Gram-negative anaerobes, including Bacteroides fragilis (MIC90 0.25 mg/l), and Gram-positive anaerobes. The MIC90 for Clostridium perfringens was 0.01 mg/l. Meropenem had comparable activity to imipenem against Gram-negative anaerobes but was more active than imipenem against clostridia, including C. difficile (MIC90 2 mg/l compared with 8 mg/l). Meropenem was more active against anaerobes than was cefoxitin, metronidazole or clindamycin.

Authors+Show Affiliations

Bacteriology Laboratory, City Hospital, Edinburgh, UK.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2808203

Citation

Watt, B, and M Naden. "The Growth-inhibitory Properties of Meropenem Against Anaerobes of Clinical Importance." The Journal of Antimicrobial Chemotherapy, vol. 24 Suppl A, 1989, pp. 119-24.
Watt B, Naden M. The growth-inhibitory properties of meropenem against anaerobes of clinical importance. J Antimicrob Chemother. 1989;24 Suppl A:119-24.
Watt, B., & Naden, M. (1989). The growth-inhibitory properties of meropenem against anaerobes of clinical importance. The Journal of Antimicrobial Chemotherapy, 24 Suppl A, 119-24.
Watt B, Naden M. The Growth-inhibitory Properties of Meropenem Against Anaerobes of Clinical Importance. J Antimicrob Chemother. 1989;24 Suppl A:119-24. PubMed PMID: 2808203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The growth-inhibitory properties of meropenem against anaerobes of clinical importance. AU - Watt,B, AU - Naden,M, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 119 EP - 24 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 24 Suppl A N2 - The in-vitro activity of meropenem against anaerobic bacteria was assessed by an agar dilution procedure. MICs were measured for 449 clinical isolates and reference strains. Meropenem showed excellent activity against both Gram-negative anaerobes, including Bacteroides fragilis (MIC90 0.25 mg/l), and Gram-positive anaerobes. The MIC90 for Clostridium perfringens was 0.01 mg/l. Meropenem had comparable activity to imipenem against Gram-negative anaerobes but was more active than imipenem against clostridia, including C. difficile (MIC90 2 mg/l compared with 8 mg/l). Meropenem was more active against anaerobes than was cefoxitin, metronidazole or clindamycin. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/2808203/The_growth_inhibitory_properties_of_meropenem_against_anaerobes_of_clinical_importance_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/24.suppl_a.119 DB - PRIME DP - Unbound Medicine ER -