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Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: A review for the gastroenterologist.

Abstract

BACKGROUND

Joint hypermobility syndrome (JHS)/Ehlers-Danlos syndrome hypermobility type (EDS-HT) is the most common hereditary non-inflammatory disorder of connective tissue, characterized by a wide range of symptoms, mainly joint hyperextensibility and musculoskeletal symptoms. A majority of patients also experiences gastrointestinal (GI) symptoms. Furthermore, JHS/EDS-HT has specifically been shown to be highly prevalent in patients with functional GI disorders, such as functional dyspepsia and irritable bowel syndrome.

PURPOSE

The aim of this review was to examine the nature of GI symptoms and their underlying pathophysiology in JHS/EDS-HT. In addition, we consider the clinical implications of the diagnosis and treatment of JHS/EDS-HT for practicing clinicians in gastroenterology. Observations summarized in this review may furthermore represent the first step toward the identification of a new pathophysiological basis for a substantial subgroup of patients with functional GI disorders.

Authors+Show Affiliations

Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.Wingate Institute of Neurogastroenterology, Centre for Digestive Diseases, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.Wingate Institute of Neurogastroenterology, Centre for Digestive Diseases, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Department of Gastroenterology, University Hospitals of North Midlands, Stoke on Trent, Staffordshire, UK.Wingate Institute of Neurogastroenterology, Centre for Digestive Diseases, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28086259

Citation

Beckers, A B., et al. "Gastrointestinal Disorders in Joint Hypermobility syndrome/Ehlers-Danlos Syndrome Hypermobility Type: a Review for the Gastroenterologist." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 29, no. 8, 2017.
Beckers AB, Keszthelyi D, Fikree A, et al. Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: A review for the gastroenterologist. Neurogastroenterol Motil. 2017;29(8).
Beckers, A. B., Keszthelyi, D., Fikree, A., Vork, L., Masclee, A., Farmer, A. D., & Aziz, Q. (2017). Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: A review for the gastroenterologist. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 29(8), doi:10.1111/nmo.13013.
Beckers AB, et al. Gastrointestinal Disorders in Joint Hypermobility syndrome/Ehlers-Danlos Syndrome Hypermobility Type: a Review for the Gastroenterologist. Neurogastroenterol Motil. 2017;29(8) PubMed PMID: 28086259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: A review for the gastroenterologist. AU - Beckers,A B, AU - Keszthelyi,D, AU - Fikree,A, AU - Vork,L, AU - Masclee,A, AU - Farmer,A D, AU - Aziz,Q, Y1 - 2017/01/13/ PY - 2016/06/22/received PY - 2016/11/23/accepted PY - 2017/1/14/pubmed PY - 2018/5/1/medline PY - 2017/1/14/entrez KW - Ehlers-Danlos syndrome KW - functional GI disorders KW - functional dyspepsia KW - joint hypermobility syndrome JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol. Motil. VL - 29 IS - 8 N2 - BACKGROUND: Joint hypermobility syndrome (JHS)/Ehlers-Danlos syndrome hypermobility type (EDS-HT) is the most common hereditary non-inflammatory disorder of connective tissue, characterized by a wide range of symptoms, mainly joint hyperextensibility and musculoskeletal symptoms. A majority of patients also experiences gastrointestinal (GI) symptoms. Furthermore, JHS/EDS-HT has specifically been shown to be highly prevalent in patients with functional GI disorders, such as functional dyspepsia and irritable bowel syndrome. PURPOSE: The aim of this review was to examine the nature of GI symptoms and their underlying pathophysiology in JHS/EDS-HT. In addition, we consider the clinical implications of the diagnosis and treatment of JHS/EDS-HT for practicing clinicians in gastroenterology. Observations summarized in this review may furthermore represent the first step toward the identification of a new pathophysiological basis for a substantial subgroup of patients with functional GI disorders. SN - 1365-2982 UR - https://www.unboundmedicine.com/medline/citation/28086259/Gastrointestinal_disorders_in_joint_hypermobility_syndrome/Ehlers_Danlos_syndrome_hypermobility_type:_A_review_for_the_gastroenterologist_ L2 - https://doi.org/10.1111/nmo.13013 DB - PRIME DP - Unbound Medicine ER -