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Examining the reliability and validity of the Clinical Assessment Interview for Negative Symptoms within the Management of Schizophrenia in Clinical Practice (MOSAIC) multisite national study.
Schizophr Res. 2017 07; 185:137-143.SR

Abstract

The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CAINS were examined within the Management of Schizophrenia in Clinical Practice (MOSAIC) schizophrenia registry. A total of 501 participants with a schizophrenia spectrum diagnosis who were receiving usual care were recruited across 15 national Patient Assessment Centers and evaluated with the CAINS, other negative symptom measures, and assessments of functioning, quality of life and cognition. Temporal stability of negative symptoms was assessed across a 3-month follow-up. Results replicated the two-factor structure of the CAINS reflecting Motivation and Pleasure and expression symptoms. The CAINS scales exhibited high internal consistency and temporal stability. Convergent validity was supported by significant correlations between the CAINS subscales with other negative symptom measures. Additionally, the CAINS was significantly correlated with functioning and quality of life. Discriminant validity was demonstrated by small to moderate associations between the CAINS and positive symptoms, depression, and cognition (and these associations were comparable to those found with other negative symptom scales). Findings suggest that the CAINS is a reliable and valid tool for measuring negative symptoms in schizophrenia across diverse clinical samples and settings.

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Authors+Show Affiliations

Blanchard JJ
University of Maryland, College Park, MD 20742, USA. Electronic address: jblancha@umd.edu.
Bradshaw KR
University of Maryland, College Park, MD 20742, USA.
Garcia CP
University of Maryland, College Park, MD 20742, USA.
Nasrallah HA
Saint Louis University, 1438 S. Grand Boulevard, Saint Louis, MO 63104 3, USA.
Harvey PD
University of Miami, Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136, USA.
Casey D
Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.
Csoboth CT
Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Hudson JI
Harvard Medical School/McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
Julian L
Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Lentz E
Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Nuechterlein KH
University of California, Los Angeles, 300 UCLA Medical Plaza, Los Angeles, CA 90095-6968, USA.
Perkins DO
University of North Carolina, Chapel Hill, NC, USA.
Skale TG
Greater Cincinnati Behavioral Health Services, 1501 Madison Road, Walnut Hills, OH 45206, USA.
Snowden LR
University of California, Berkeley, CA, USA.
Tandon R
University of Florida, Gainesville, FL 32611, USA.
Tek C
Yale University/Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA.
Velligan D
University of Texas Health Science Center, 7703 Floyd Curl Dr. San Antonio, San Antonio, TX 78240, USA.
Vinogradov S
University of California, San Francisco, 500 Parnassus Avenue, San Francisco, CA 94143, USA; San Francisco Veterans Administration Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA.
O'Gorman C
Formerly of Genentech. Currently at Intra-Cellular Therapies, Inc., 430 East 29th Street, New York City, NY 10016, USA.

MeSH

AdolescentAdultAgedAged, 80 and overCognition DisordersFactor Analysis, StatisticalFemaleHumansInternational CooperationInterview, PsychologicalMaleMiddle AgedPsychiatric Status Rating ScalesQuality of LifeReproducibility of ResultsSchizophreniaSchizophrenic PsychologyYoung Adult

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28087270

Citation

Blanchard, Jack J., et al. "Examining the Reliability and Validity of the Clinical Assessment Interview for Negative Symptoms Within the Management of Schizophrenia in Clinical Practice (MOSAIC) Multisite National Study." Schizophrenia Research, vol. 185, 2017, pp. 137-143.
Blanchard JJ, Bradshaw KR, Garcia CP, et al. Examining the reliability and validity of the Clinical Assessment Interview for Negative Symptoms within the Management of Schizophrenia in Clinical Practice (MOSAIC) multisite national study. Schizophr Res. 2017;185:137-143.
Blanchard, J. J., Bradshaw, K. R., Garcia, C. P., Nasrallah, H. A., Harvey, P. D., Casey, D., Csoboth, C. T., Hudson, J. I., Julian, L., Lentz, E., Nuechterlein, K. H., Perkins, D. O., Skale, T. G., Snowden, L. R., Tandon, R., Tek, C., Velligan, D., Vinogradov, S., & O'Gorman, C. (2017). Examining the reliability and validity of the Clinical Assessment Interview for Negative Symptoms within the Management of Schizophrenia in Clinical Practice (MOSAIC) multisite national study. Schizophrenia Research, 185, 137-143. https://doi.org/10.1016/j.schres.2017.01.011
Blanchard JJ, et al. Examining the Reliability and Validity of the Clinical Assessment Interview for Negative Symptoms Within the Management of Schizophrenia in Clinical Practice (MOSAIC) Multisite National Study. Schizophr Res. 2017;185:137-143. PubMed PMID: 28087270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Examining the reliability and validity of the Clinical Assessment Interview for Negative Symptoms within the Management of Schizophrenia in Clinical Practice (MOSAIC) multisite national study. AU - Blanchard,Jack J, AU - Bradshaw,Kristen R, AU - Garcia,Cristina P, AU - Nasrallah,Henry A, AU - Harvey,Philip D, AU - Casey,Daniel, AU - Csoboth,Csilla T, AU - Hudson,James I, AU - Julian,Laura, AU - Lentz,Ellen, AU - Nuechterlein,Keith H, AU - Perkins,Diana O, AU - Skale,Tracey G, AU - Snowden,Lonnie R, AU - Tandon,Rajiv, AU - Tek,Cenk, AU - Velligan,Dawn, AU - Vinogradov,Sophia, AU - O'Gorman,Cedric, Y1 - 2017/01/11/ PY - 2016/04/13/received PY - 2017/01/05/revised PY - 2017/01/05/accepted PY - 2017/1/15/pubmed PY - 2018/3/27/medline PY - 2017/1/15/entrez KW - Assessment KW - Clinical interview KW - Functioning KW - Negative symptoms KW - Schizophrenia SP - 137 EP - 143 JF - Schizophrenia research JO - Schizophr Res VL - 185 N2 - The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CAINS were examined within the Management of Schizophrenia in Clinical Practice (MOSAIC) schizophrenia registry. A total of 501 participants with a schizophrenia spectrum diagnosis who were receiving usual care were recruited across 15 national Patient Assessment Centers and evaluated with the CAINS, other negative symptom measures, and assessments of functioning, quality of life and cognition. Temporal stability of negative symptoms was assessed across a 3-month follow-up. Results replicated the two-factor structure of the CAINS reflecting Motivation and Pleasure and expression symptoms. The CAINS scales exhibited high internal consistency and temporal stability. Convergent validity was supported by significant correlations between the CAINS subscales with other negative symptom measures. Additionally, the CAINS was significantly correlated with functioning and quality of life. Discriminant validity was demonstrated by small to moderate associations between the CAINS and positive symptoms, depression, and cognition (and these associations were comparable to those found with other negative symptom scales). Findings suggest that the CAINS is a reliable and valid tool for measuring negative symptoms in schizophrenia across diverse clinical samples and settings. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/28087270/Examining_the_reliability_and_validity_of_the_Clinical_Assessment_Interview_for_Negative_Symptoms_within_the_Management_of_Schizophrenia_in_Clinical_Practice__MOSAIC__multisite_national_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(17)30011-7 DB - PRIME DP - Unbound Medicine ER -