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Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma.
Am J Ophthalmol. 2017 Apr; 176:53-60.AJ

Abstract

PURPOSE

To study the relationship between horizontal central retinal vessel trunk location (CRVTL) on glaucomatous optic discs and sector-specific visual field (VF) loss.

DESIGN

Retrospective cross-sectional study.

METHODS

CRVTL of 421 eyes from 421 patients was manually tracked on the horizontal optic disc axis on fundus images. Focal circumpapillary retinal nerve fiber layer thickness (cpRNFLT) measurements were extracted from optical coherence tomography (OCT). The relationship between focal visual field (VF) loss and CRVTL and focal cpRNFLT was studied by linear regression models. Furthermore, we related central VF loss to CRVTL and focal cpRNFLT separately for mild (VF mean deviation [MD] ≥-6 dB), moderate (-12 dB ≤ MD <-6 dB), and severe (MD <-12 dB) glaucoma.

RESULTS

CRVTL nasalization was significantly correlated only to central VF loss (Garway-Heath scheme [central 6 locations, C6]: correlation: r = -0.16, P < .001; macular vulnerability zone [central 2 locations, C2]: r = -0.14, P = .003; central 4 locations [C4]: r = -0.17, P < .001). While focal cpRNFLT at the sectors corresponding to C2 and C6 was significantly correlated to the respective VF sectors as well (C2: r = 0.15, P = .002; C6: r = 0.10, P = .03), multivariate models combining cpRNFLT and CRVTL substantially improved structure-function models compared with cpRNFLT alone (likelihood ratio tests, C2 and C6: P < .001). The correlations between CRVTL and central VF loss of C4 were -0.11 (P = .04), -0.39 (P = .01), and -0.63 (P = .002) for mild, moderate, and severe glaucoma, respectively.

CONCLUSIONS

CRVTL nasalization is significantly and exclusively correlated to central VF loss for all glaucoma severities independent of cpRNFLT, and thus might be a structural biomarker of central VF loss.

Authors+Show Affiliations

Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts.Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts; Institute for Psychology and Behavior, Jilin University of Finance and Economics, Changchun, China.Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts; Department of Biomedical Engineering and Biotechnology, University of Massachusetts, Lowell, Massachusetts.Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.Department of Psychology, Northeastern University, Boston, Massachusetts.Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts; Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany. Electronic address: tobias-elze@tobias-elze.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28088508

Citation

Wang, Mengyu, et al. "Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma." American Journal of Ophthalmology, vol. 176, 2017, pp. 53-60.
Wang M, Wang H, Pasquale LR, et al. Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma. Am J Ophthalmol. 2017;176:53-60.
Wang, M., Wang, H., Pasquale, L. R., Baniasadi, N., Shen, L. Q., Bex, P. J., & Elze, T. (2017). Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma. American Journal of Ophthalmology, 176, 53-60. https://doi.org/10.1016/j.ajo.2017.01.001
Wang M, et al. Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma. Am J Ophthalmol. 2017;176:53-60. PubMed PMID: 28088508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma. AU - Wang,Mengyu, AU - Wang,Hui, AU - Pasquale,Louis R, AU - Baniasadi,Neda, AU - Shen,Lucy Q, AU - Bex,Peter J, AU - Elze,Tobias, Y1 - 2017/01/11/ PY - 2016/11/14/received PY - 2017/01/02/revised PY - 2017/01/04/accepted PY - 2017/1/16/pubmed PY - 2017/5/10/medline PY - 2017/1/16/entrez SP - 53 EP - 60 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 176 N2 - PURPOSE: To study the relationship between horizontal central retinal vessel trunk location (CRVTL) on glaucomatous optic discs and sector-specific visual field (VF) loss. DESIGN: Retrospective cross-sectional study. METHODS: CRVTL of 421 eyes from 421 patients was manually tracked on the horizontal optic disc axis on fundus images. Focal circumpapillary retinal nerve fiber layer thickness (cpRNFLT) measurements were extracted from optical coherence tomography (OCT). The relationship between focal visual field (VF) loss and CRVTL and focal cpRNFLT was studied by linear regression models. Furthermore, we related central VF loss to CRVTL and focal cpRNFLT separately for mild (VF mean deviation [MD] ≥-6 dB), moderate (-12 dB ≤ MD <-6 dB), and severe (MD <-12 dB) glaucoma. RESULTS: CRVTL nasalization was significantly correlated only to central VF loss (Garway-Heath scheme [central 6 locations, C6]: correlation: r = -0.16, P < .001; macular vulnerability zone [central 2 locations, C2]: r = -0.14, P = .003; central 4 locations [C4]: r = -0.17, P < .001). While focal cpRNFLT at the sectors corresponding to C2 and C6 was significantly correlated to the respective VF sectors as well (C2: r = 0.15, P = .002; C6: r = 0.10, P = .03), multivariate models combining cpRNFLT and CRVTL substantially improved structure-function models compared with cpRNFLT alone (likelihood ratio tests, C2 and C6: P < .001). The correlations between CRVTL and central VF loss of C4 were -0.11 (P = .04), -0.39 (P = .01), and -0.63 (P = .002) for mild, moderate, and severe glaucoma, respectively. CONCLUSIONS: CRVTL nasalization is significantly and exclusively correlated to central VF loss for all glaucoma severities independent of cpRNFLT, and thus might be a structural biomarker of central VF loss. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/28088508/Relationship_Between_Central_Retinal_Vessel_Trunk_Location_and_Visual_Field_Loss_in_Glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(17)30006-5 DB - PRIME DP - Unbound Medicine ER -