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White matter alterations in college football players: a longitudinal diffusion tensor imaging study.
Brain Imaging Behav 2018; 12(1):44-53BI

Abstract

The aim of this study was to evaluate longitudinal changes in the diffusion characteristics of brain white matter (WM) in collegiate athletes at three time points: prior to the start of the football season (T1), after one season of football (T2), followed by six months of no-contact rest (T3). Fifteen male collegiate football players and 5 male non-athlete student controls underwent diffusion MR imaging and computerized cognitive testing at all three timepoints. Whole-brain tract-based spatial statistics (TBSS) were used to compare fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and trace between all timepoints. Average diffusion values were obtained from statistically significant clusters for each individual. No athlete suffered a concussion during the study period. After one season of play (T1 to T2), we observed a significant increase in trace in a cluster located in the brainstem and left temporal lobe, and a significant increase in FA in the left parietal lobe. After six months of no-contact rest (T2 to T3), there was a significant decrease in trace and FA in clusters that were partially overlapping or in close proximity with the initial clusters (T1 to T2), with no significant changes from T1 to T3. Repetitive head impacts (RHI) sustained during a single football season may result in alterations of the brain's WM in collegiate football players. These changes appear to return to baseline after 6 months of no-contact rest, suggesting remission of WM alterations. Our preliminary results suggest that collegiate football players might benefit from periods without exposure to RHI.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany. Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Pediatric Neurology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians- Universität, Munich, Germany.Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Institute for Clinical Radiology, Ludwig-Maximilians-Universität, Munich, Germany.Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Institute for Clinical Radiology, Ludwig-Maximilians-Universität, Munich, Germany.Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. VA Boston Healthcare System, Brockton Division, Brockton, MA, USA.Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany. ikoerte@bwh.harvard.edu. Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ikoerte@bwh.harvard.edu.Psychiatry Neuroimaging Laboratory, Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28092023

Citation

Mayinger, Michael Christian, et al. "White Matter Alterations in College Football Players: a Longitudinal Diffusion Tensor Imaging Study." Brain Imaging and Behavior, vol. 12, no. 1, 2018, pp. 44-53.
Mayinger MC, Merchant-Borna K, Hufschmidt J, et al. White matter alterations in college football players: a longitudinal diffusion tensor imaging study. Brain Imaging Behav. 2018;12(1):44-53.
Mayinger, M. C., Merchant-Borna, K., Hufschmidt, J., Muehlmann, M., Weir, I. R., Rauchmann, B. S., ... Bazarian, J. J. (2018). White matter alterations in college football players: a longitudinal diffusion tensor imaging study. Brain Imaging and Behavior, 12(1), pp. 44-53. doi:10.1007/s11682-017-9672-4.
Mayinger MC, et al. White Matter Alterations in College Football Players: a Longitudinal Diffusion Tensor Imaging Study. Brain Imaging Behav. 2018;12(1):44-53. PubMed PMID: 28092023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White matter alterations in college football players: a longitudinal diffusion tensor imaging study. AU - Mayinger,Michael Christian, AU - Merchant-Borna,Kian, AU - Hufschmidt,Jakob, AU - Muehlmann,Marc, AU - Weir,Isabelle Ruth, AU - Rauchmann,Boris-Stephan, AU - Shenton,Martha Elizabeth, AU - Koerte,Inga Katharina, AU - Bazarian,Jeffrey John, PY - 2017/1/17/pubmed PY - 2018/8/28/medline PY - 2017/1/17/entrez KW - Athletics KW - Diffusion tensor imaging KW - Football KW - Fractional anisotropy KW - High magnitude impact KW - Human studies KW - Longitudinal KW - Repetitive head impacts KW - Sports KW - Subconcussive head trauma KW - TBSS KW - White matter SP - 44 EP - 53 JF - Brain imaging and behavior JO - Brain Imaging Behav VL - 12 IS - 1 N2 - The aim of this study was to evaluate longitudinal changes in the diffusion characteristics of brain white matter (WM) in collegiate athletes at three time points: prior to the start of the football season (T1), after one season of football (T2), followed by six months of no-contact rest (T3). Fifteen male collegiate football players and 5 male non-athlete student controls underwent diffusion MR imaging and computerized cognitive testing at all three timepoints. Whole-brain tract-based spatial statistics (TBSS) were used to compare fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and trace between all timepoints. Average diffusion values were obtained from statistically significant clusters for each individual. No athlete suffered a concussion during the study period. After one season of play (T1 to T2), we observed a significant increase in trace in a cluster located in the brainstem and left temporal lobe, and a significant increase in FA in the left parietal lobe. After six months of no-contact rest (T2 to T3), there was a significant decrease in trace and FA in clusters that were partially overlapping or in close proximity with the initial clusters (T1 to T2), with no significant changes from T1 to T3. Repetitive head impacts (RHI) sustained during a single football season may result in alterations of the brain's WM in collegiate football players. These changes appear to return to baseline after 6 months of no-contact rest, suggesting remission of WM alterations. Our preliminary results suggest that collegiate football players might benefit from periods without exposure to RHI. SN - 1931-7565 UR - https://www.unboundmedicine.com/medline/citation/28092023/White_matter_alterations_in_college_football_players:_a_longitudinal_diffusion_tensor_imaging_study_ L2 - https://dx.doi.org/10.1007/s11682-017-9672-4 DB - PRIME DP - Unbound Medicine ER -