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Cactus (Opuntia humifusa) water extract ameliorates loperamide-induced constipation in rats.
BMC Complement Altern Med. 2017 Jan 17; 17(1):49.BC

Abstract

BACKGROUND

Korean cactus Cheonnyuncho (Opuntia humifusa) is rich in pectin, phenols, flavonoids, and minerals such as calcium and phosphorus. Some Koreans drink Cheonnyuncho juice prepared by grinding Cheonnyuncho with water. Cheonnyuncho is well known for its functional properties and antioxidant effects, but its effect on constipation has not been sufficiently studied.

METHODS

Loperamide (2 mg/kg) was injected subcutaneously to induce constipation in rats. The animals were divided into four groups: a normal group (NOR), constipation control group (CON), and two constipation groups receiving the Cheonnyuncho extract (CE) at two different concentrations in drinking water, 3% (L-CE group) and 6% (H-CE group), for 25 days.

RESULTS

The fecal pellet numbers of NOR and L-CE were significantly increased from 35.67 ± 2.09 (CON) to 50.60 ± 1.38 and 46.50 ± 2.91 after loperamide treatment, respectively (p < 0.05). The water content of fecal excretions was significantly enhanced in only the L-CE group (33.05 ± 0.49%) compared to control (23.38 ± 1.26%) (p < 0.05) after loperamide treatment. The oral intake of CE (L-CE and H-CE groups) significantly increased levels of the intestinal transit ratio (45.25 ± 1.86% and 41.05 ± 2.47%, respectively) compared to the CON group (32.15 ± 2.05%) (p < 0.05). Treatment with the low concentration of CE significantly increased fecal levels of acetic, propionic, butyric, and valeric acids, as well as the total short-chain fatty acid (SCFA) concentration. Histological analyses revealed that the thickness of the distal colon also increased in the CE-treated groups in a dose-dependent manner.

CONCLUSIONS

Constipation decreased when CE was fed to the rats. In particular, the fecal pellet number and water content, as well as histological parameters such as distal colon thickness, improved. The CE treatment also increased the fecal SCFA content. These results show that the extract of Cheonnyuncho (O. humifusa) alleviated the symptoms of loperamide-induced constipation.

Authors+Show Affiliations

BK21Plus, College of Health Science, Korea University, Seoul, 02841, Republic of Korea.Regulatory Affairs & Product Compliance Korea and Philippines, Herbalife Korea, Seoul, 06052, Republic of Korea.Department of Food and Nutrition, Korea University, Seoul, 02841, Republic of Korea.Department of Food and Nutrition, Korea University, Seoul, 02841, Republic of Korea.Agency for Korea National Food Cluster, Iksan, 54622, Republic of Korea.Department of Public Health Sciences, Graduate School, Korea University, Seoul, 02841, Republic of Korea. suh1960@korea.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28095842

Citation

Han, Sung Hee, et al. "Cactus (Opuntia Humifusa) Water Extract Ameliorates Loperamide-induced Constipation in Rats." BMC Complementary and Alternative Medicine, vol. 17, no. 1, 2017, p. 49.
Han SH, Park K, Kim EY, et al. Cactus (Opuntia humifusa) water extract ameliorates loperamide-induced constipation in rats. BMC Complement Altern Med. 2017;17(1):49.
Han, S. H., Park, K., Kim, E. Y., Ahn, S. H., Lee, H. S., & Suh, H. J. (2017). Cactus (Opuntia humifusa) water extract ameliorates loperamide-induced constipation in rats. BMC Complementary and Alternative Medicine, 17(1), 49. https://doi.org/10.1186/s12906-016-1552-8
Han SH, et al. Cactus (Opuntia Humifusa) Water Extract Ameliorates Loperamide-induced Constipation in Rats. BMC Complement Altern Med. 2017 Jan 17;17(1):49. PubMed PMID: 28095842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cactus (Opuntia humifusa) water extract ameliorates loperamide-induced constipation in rats. AU - Han,Sung Hee, AU - Park,Kyungmi, AU - Kim,Eun Young, AU - Ahn,So Hyun, AU - Lee,Hyun-Sun, AU - Suh,Hyung Joo, Y1 - 2017/01/17/ PY - 2016/06/04/received PY - 2016/09/28/accepted PY - 2017/1/19/entrez PY - 2017/1/18/pubmed PY - 2017/1/26/medline KW - Cheonnyuncho KW - Constipation KW - Gastrointestinal transit KW - Loperamide KW - Opuntia humifusa SP - 49 EP - 49 JF - BMC complementary and alternative medicine JO - BMC Complement Altern Med VL - 17 IS - 1 N2 - BACKGROUND: Korean cactus Cheonnyuncho (Opuntia humifusa) is rich in pectin, phenols, flavonoids, and minerals such as calcium and phosphorus. Some Koreans drink Cheonnyuncho juice prepared by grinding Cheonnyuncho with water. Cheonnyuncho is well known for its functional properties and antioxidant effects, but its effect on constipation has not been sufficiently studied. METHODS: Loperamide (2 mg/kg) was injected subcutaneously to induce constipation in rats. The animals were divided into four groups: a normal group (NOR), constipation control group (CON), and two constipation groups receiving the Cheonnyuncho extract (CE) at two different concentrations in drinking water, 3% (L-CE group) and 6% (H-CE group), for 25 days. RESULTS: The fecal pellet numbers of NOR and L-CE were significantly increased from 35.67 ± 2.09 (CON) to 50.60 ± 1.38 and 46.50 ± 2.91 after loperamide treatment, respectively (p < 0.05). The water content of fecal excretions was significantly enhanced in only the L-CE group (33.05 ± 0.49%) compared to control (23.38 ± 1.26%) (p < 0.05) after loperamide treatment. The oral intake of CE (L-CE and H-CE groups) significantly increased levels of the intestinal transit ratio (45.25 ± 1.86% and 41.05 ± 2.47%, respectively) compared to the CON group (32.15 ± 2.05%) (p < 0.05). Treatment with the low concentration of CE significantly increased fecal levels of acetic, propionic, butyric, and valeric acids, as well as the total short-chain fatty acid (SCFA) concentration. Histological analyses revealed that the thickness of the distal colon also increased in the CE-treated groups in a dose-dependent manner. CONCLUSIONS: Constipation decreased when CE was fed to the rats. In particular, the fecal pellet number and water content, as well as histological parameters such as distal colon thickness, improved. The CE treatment also increased the fecal SCFA content. These results show that the extract of Cheonnyuncho (O. humifusa) alleviated the symptoms of loperamide-induced constipation. SN - 1472-6882 UR - https://www.unboundmedicine.com/medline/citation/28095842/Cactus__Opuntia_humifusa__water_extract_ameliorates_loperamide_induced_constipation_in_rats_ DB - PRIME DP - Unbound Medicine ER -