Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement.
ImportanceNeural tube defects are among the most common major congenital anomalies in the United States and may lead to a range of disabilities or death. Daily folic acid supplementation in the periconceptional period can prevent neural tube defects. However, most women do not receive the recommended daily intake of folate from diet alone.
ObjectiveTo update the 2009 US Preventive Services Task Force (USPSTF) recommendation on folic acid supplementation in women of childbearing age.
Evidence ReviewIn 2009, the USPSTF reviewed the effectiveness of folic acid supplementation in women of childbearing age for the prevention of neural tube defects in infants. The current review assessed new evidence on the benefits and harms of folic acid supplementation.
FindingsThe USPSTF assessed the balance of the benefits and harms of folic acid supplementation in women of childbearing age and determined that the net benefit is substantial. Evidence is adequate that the harms to the mother or infant from folic acid supplementation taken at the usual doses are no greater than small. Therefore, the USPSTF reaffirms its 2009 recommendation.
Conclusions and RecommendationThe USPSTF recommends that all women who are planning or capable of pregnancy take a daily supplement containing 0.4 to 0.8 mg (400-800 µg) of folic acid. (A recommendation).
Authors+Show Affiliations, ,
University of California, San Francisco.,
Group Health Research Institute, Seattle, Washington.,
University of Iowa, Iowa City.,
Columbia University, New York, New York.,
State University of New York Upstate Medical University, Syracuse.,
Pima County Department of Health, Tucson, Arizona.,
Duke University, Durham, North Carolina.,
Fairfax Family Practice Residency, Fairfax, Virginia9Virginia Commonwealth University, Richmond.,
Yale University, New Haven, Connecticut.,
University of Alabama at Birmingham.,
University of California, Los Angeles.,
University of Washington, Seattle.,
Brown University, Providence, Rhode Island.,
University of Texas at Austin.,
Boston University, Boston, Massachusetts.
University of Hawaii, Manoa.
Neural Tube Defects
Recommended Dietary Allowances
Vitamin B Complex
Research Support, Non-U.S. Gov't