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Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement.
JAMA 2017; 317(2):183-189JAMA

Abstract

Importance

Neural tube defects are among the most common major congenital anomalies in the United States and may lead to a range of disabilities or death. Daily folic acid supplementation in the periconceptional period can prevent neural tube defects. However, most women do not receive the recommended daily intake of folate from diet alone.

Objective

To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on folic acid supplementation in women of childbearing age.

Evidence Review

In 2009, the USPSTF reviewed the effectiveness of folic acid supplementation in women of childbearing age for the prevention of neural tube defects in infants. The current review assessed new evidence on the benefits and harms of folic acid supplementation.

Findings

The USPSTF assessed the balance of the benefits and harms of folic acid supplementation in women of childbearing age and determined that the net benefit is substantial. Evidence is adequate that the harms to the mother or infant from folic acid supplementation taken at the usual doses are no greater than small. Therefore, the USPSTF reaffirms its 2009 recommendation.

Conclusions and Recommendation

The USPSTF recommends that all women who are planning or capable of pregnancy take a daily supplement containing 0.4 to 0.8 mg (400-800 µg) of folic acid. (A recommendation).

Authors+Show Affiliations

No affiliation info availableUniversity of California, San Francisco.Group Health Research Institute, Seattle, Washington.University of Iowa, Iowa City.Columbia University, New York, New York.State University of New York Upstate Medical University, Syracuse.Pima County Department of Health, Tucson, Arizona.Duke University, Durham, North Carolina.Fairfax Family Practice Residency, Fairfax, Virginia9Virginia Commonwealth University, Richmond.Yale University, New Haven, Connecticut.University of Alabama at Birmingham.University of California, Los Angeles.University of Washington, Seattle.Brown University, Providence, Rhode Island.University of Texas at Austin.Boston University, Boston, Massachusetts.University of Hawaii, Manoa.

Pub Type(s)

Guideline
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28097362

Citation

US Preventive Services Task Force, et al. "Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement." JAMA, vol. 317, no. 2, 2017, pp. 183-189.
US Preventive Services Task Force, Bibbins-Domingo K, Grossman DC, et al. Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement. JAMA. 2017;317(2):183-189.
Bibbins-Domingo, K., Grossman, D. C., Curry, S. J., Davidson, K. W., Epling, J. W., García, F. A., ... Tseng, C. W. (2017). Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement. JAMA, 317(2), pp. 183-189. doi:10.1001/jama.2016.19438.
US Preventive Services Task Force, et al. Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement. JAMA. 2017 01 10;317(2):183-189. PubMed PMID: 28097362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement. AU - ,, AU - Bibbins-Domingo,Kirsten, AU - Grossman,David C, AU - Curry,Susan J, AU - Davidson,Karina W, AU - Epling,John W,Jr AU - García,Francisco A R, AU - Kemper,Alex R, AU - Krist,Alex H, AU - Kurth,Ann E, AU - Landefeld,C Seth, AU - Mangione,Carol M, AU - Phillips,William R, AU - Phipps,Maureen G, AU - Pignone,Michael P, AU - Silverstein,Michael, AU - Tseng,Chien-Wen, PY - 2017/1/19/entrez PY - 2017/1/18/pubmed PY - 2017/2/10/medline SP - 183 EP - 189 JF - JAMA JO - JAMA VL - 317 IS - 2 N2 - Importance: Neural tube defects are among the most common major congenital anomalies in the United States and may lead to a range of disabilities or death. Daily folic acid supplementation in the periconceptional period can prevent neural tube defects. However, most women do not receive the recommended daily intake of folate from diet alone. Objective: To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on folic acid supplementation in women of childbearing age. Evidence Review: In 2009, the USPSTF reviewed the effectiveness of folic acid supplementation in women of childbearing age for the prevention of neural tube defects in infants. The current review assessed new evidence on the benefits and harms of folic acid supplementation. Findings: The USPSTF assessed the balance of the benefits and harms of folic acid supplementation in women of childbearing age and determined that the net benefit is substantial. Evidence is adequate that the harms to the mother or infant from folic acid supplementation taken at the usual doses are no greater than small. Therefore, the USPSTF reaffirms its 2009 recommendation. Conclusions and Recommendation: The USPSTF recommends that all women who are planning or capable of pregnancy take a daily supplement containing 0.4 to 0.8 mg (400-800 µg) of folic acid. (A recommendation). SN - 1538-3598 UR - https://www.unboundmedicine.com/medline/citation/28097362/Folic_Acid_Supplementation_for_the_Prevention_of_Neural_Tube_Defects:_US_Preventive_Services_Task_Force_Recommendation_Statement_ L2 - https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2016.19438 DB - PRIME DP - Unbound Medicine ER -