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Alcohol consumption and dementia risk: a dose-response meta-analysis of prospective studies.
Eur J Epidemiol. 2017 01; 32(1):31-42.EJ

Abstract

It is widely believed that light-to-moderate alcohol intake may protect against dementia while excessive drinking may instead increase the risk. Nonetheless, these findings need cautious interpretations due to varying methodologies and lack of standard definition, which hindered our transferring into preventative practice. The objective of this study is to investigate the potential dose-response association between alcohol consumption and risk of dementia. A systematic search was conducted in electronic databases to identify relevant studies. Risk estimates were combined using a random-effect model. Eleven studies with 73,330 participants and 4586 cases for all-cause dementia (ACD), five studies with 52,715 participants and 1267 cases for Alzheimer's dementia (AD) and four studies with 49,535 participants and 542 cases for vascular dementia were included. We observed a nonlinear association between alcohol consumption and ACD risk (p nonlinearity < 0.05). The alcohol dose associated with lower risk of dementia was confined to at most 12.5 g/day, with the risk hitting bottom (RR ≈ 0.9) at roughly 6 g/day. Of note, the ACD risk seemed to be elevated (≈10%) when the dose surpasses certain levels: 23 drinks/week or 38 g/day. For the alcohol type, recommendation for wine is prioritized. The subgroup analysis further indicated that the effect of alcohol may be greater in younger adults (<60 years old) with regard to fighting against dementia. Modest alcohol consumption (≤12.5 g/day) is associated with a reduced risk of dementia with 6 g/day of alcohol conferring a lower risk than other levels while excessive drinking (≥38 g/day) may instead elevate the risk.

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Authors+Show Affiliations

Xu W
College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China.
Wang H
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Wan Y
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Tan C
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Li J
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Tan L
College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China. dr.tanlan@163.com. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China. dr.tanlan@163.com.
Yu JT
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China. yu-jintai@163.com.

MeSH

Alcohol DrinkingAlzheimer DiseaseDementiaDose-Response Relationship, DrugFemaleHumansMaleRisk Factors

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

28097521

Citation

Xu, Wei, et al. "Alcohol Consumption and Dementia Risk: a Dose-response Meta-analysis of Prospective Studies." European Journal of Epidemiology, vol. 32, no. 1, 2017, pp. 31-42.
Xu W, Wang H, Wan Y, et al. Alcohol consumption and dementia risk: a dose-response meta-analysis of prospective studies. Eur J Epidemiol. 2017;32(1):31-42.
Xu, W., Wang, H., Wan, Y., Tan, C., Li, J., Tan, L., & Yu, J. T. (2017). Alcohol consumption and dementia risk: a dose-response meta-analysis of prospective studies. European Journal of Epidemiology, 32(1), 31-42. https://doi.org/10.1007/s10654-017-0225-3
Xu W, et al. Alcohol Consumption and Dementia Risk: a Dose-response Meta-analysis of Prospective Studies. Eur J Epidemiol. 2017;32(1):31-42. PubMed PMID: 28097521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and dementia risk: a dose-response meta-analysis of prospective studies. AU - Xu,Wei, AU - Wang,Huifu, AU - Wan,Yu, AU - Tan,Chenchen, AU - Li,Jieqiong, AU - Tan,Lan, AU - Yu,Jin-Tai, Y1 - 2017/01/17/ PY - 2016/10/20/received PY - 2017/01/07/accepted PY - 2017/1/18/pubmed PY - 2017/12/30/medline PY - 2017/1/19/entrez KW - Alcohol KW - Dementia KW - Dose–response KW - Meta-analysis SP - 31 EP - 42 JF - European journal of epidemiology JO - Eur J Epidemiol VL - 32 IS - 1 N2 - It is widely believed that light-to-moderate alcohol intake may protect against dementia while excessive drinking may instead increase the risk. Nonetheless, these findings need cautious interpretations due to varying methodologies and lack of standard definition, which hindered our transferring into preventative practice. The objective of this study is to investigate the potential dose-response association between alcohol consumption and risk of dementia. A systematic search was conducted in electronic databases to identify relevant studies. Risk estimates were combined using a random-effect model. Eleven studies with 73,330 participants and 4586 cases for all-cause dementia (ACD), five studies with 52,715 participants and 1267 cases for Alzheimer's dementia (AD) and four studies with 49,535 participants and 542 cases for vascular dementia were included. We observed a nonlinear association between alcohol consumption and ACD risk (p nonlinearity < 0.05). The alcohol dose associated with lower risk of dementia was confined to at most 12.5 g/day, with the risk hitting bottom (RR ≈ 0.9) at roughly 6 g/day. Of note, the ACD risk seemed to be elevated (≈10%) when the dose surpasses certain levels: 23 drinks/week or 38 g/day. For the alcohol type, recommendation for wine is prioritized. The subgroup analysis further indicated that the effect of alcohol may be greater in younger adults (<60 years old) with regard to fighting against dementia. Modest alcohol consumption (≤12.5 g/day) is associated with a reduced risk of dementia with 6 g/day of alcohol conferring a lower risk than other levels while excessive drinking (≥38 g/day) may instead elevate the risk. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/28097521/Alcohol_consumption_and_dementia_risk:_a_dose_response_meta_analysis_of_prospective_studies_ DB - PRIME DP - Unbound Medicine ER -