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Helicobacter pylori and Risk of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis.
J Clin Gastroenterol. 2018 May/Jun; 52(5):386-391.JC

Abstract

BACKGROUND/OBJECTIVES

Helicobacter pylori (H. pylori) is the most common chronic bacterial infection. Patients with H. pylori infection may be at an increased risk of nonalcoholic fatty liver disease (NAFLD) because of chronic inflammation and insulin resistance. Several epidemiologic studies attempting to determine this risk have yielded inconsistent results. This meta-analysis was conducted with the aims to summarize all available evidence and estimate the risk of NAFLD in patients with H. pylori infection.

METHODS

A literature search was performed using MEDLINE and EMBASE database from inception to June 2016. Studies that reported relative risks, odd ratios, or hazard ratios comparing the risk of NAFLD among patients with H. pylori infection versus without H. pylori infection were included. Pooled odds ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance method.

RESULTS

Six studies met our eligibility criteria and were included in this analysis. We found a statistically significant increased risk of NAFLD among patients with H. pylori infection with the pooled odds ratios of 1.21 (95% confidence interval, 1.07-1.37). The statistical heterogeneity was low with an I of 49%.

CONCLUSIONS

A significantly increased risk of NAFLD among patients with H. pylori infection was demonstrated in this meta-analysis. Further studies are required to clarify how this risk should be addressed in clinical practice.

Authors+Show Affiliations

Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY.Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY.Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.Department of Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha, NE.Department of Internal Medicine, University of Hawaii, Honolulu, HI.Department of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN. Department of Medicine, Division of Rheumatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

28098578

Citation

Wijarnpreecha, Karn, et al. "Helicobacter Pylori and Risk of Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-analysis." Journal of Clinical Gastroenterology, vol. 52, no. 5, 2018, pp. 386-391.
Wijarnpreecha K, Thongprayoon C, Panjawatanan P, et al. Helicobacter pylori and Risk of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. J Clin Gastroenterol. 2018;52(5):386-391.
Wijarnpreecha, K., Thongprayoon, C., Panjawatanan, P., Manatsathit, W., Jaruvongvanich, V., & Ungprasert, P. (2018). Helicobacter pylori and Risk of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. Journal of Clinical Gastroenterology, 52(5), 386-391. https://doi.org/10.1097/MCG.0000000000000784
Wijarnpreecha K, et al. Helicobacter Pylori and Risk of Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-analysis. J Clin Gastroenterol. 2018 May/Jun;52(5):386-391. PubMed PMID: 28098578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori and Risk of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. AU - Wijarnpreecha,Karn, AU - Thongprayoon,Charat, AU - Panjawatanan,Panadeekarn, AU - Manatsathit,Wuttiporn, AU - Jaruvongvanich,Veeravich, AU - Ungprasert,Patompong, PY - 2017/1/19/pubmed PY - 2019/7/28/medline PY - 2017/1/19/entrez SP - 386 EP - 391 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 52 IS - 5 N2 - BACKGROUND/OBJECTIVES: Helicobacter pylori (H. pylori) is the most common chronic bacterial infection. Patients with H. pylori infection may be at an increased risk of nonalcoholic fatty liver disease (NAFLD) because of chronic inflammation and insulin resistance. Several epidemiologic studies attempting to determine this risk have yielded inconsistent results. This meta-analysis was conducted with the aims to summarize all available evidence and estimate the risk of NAFLD in patients with H. pylori infection. METHODS: A literature search was performed using MEDLINE and EMBASE database from inception to June 2016. Studies that reported relative risks, odd ratios, or hazard ratios comparing the risk of NAFLD among patients with H. pylori infection versus without H. pylori infection were included. Pooled odds ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance method. RESULTS: Six studies met our eligibility criteria and were included in this analysis. We found a statistically significant increased risk of NAFLD among patients with H. pylori infection with the pooled odds ratios of 1.21 (95% confidence interval, 1.07-1.37). The statistical heterogeneity was low with an I of 49%. CONCLUSIONS: A significantly increased risk of NAFLD among patients with H. pylori infection was demonstrated in this meta-analysis. Further studies are required to clarify how this risk should be addressed in clinical practice. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/28098578/Helicobacter_pylori_and_Risk_of_Nonalcoholic_Fatty_Liver_Disease:_A_Systematic_Review_and_Meta_analysis_ L2 - https://doi.org/10.1097/MCG.0000000000000784 DB - PRIME DP - Unbound Medicine ER -