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Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins.Am J Clin Nutr. 2017 03; 105(3):626-634.AJ
Abstract
Background:
Although dietary flavonoid intake has been associated with less weight gain, there are limited data on its impact on fat mass, and to our knowledge, the contribution of genetic factors to this relation has not previously been assessed.Objective:
We examined the associations between flavonoid intakes and fat mass.Design:
In a study of 2734 healthy, female twins aged 18-83 y from the TwinsUK registry, intakes of total flavonoids and 7 subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers, and proanthocyanidins) were calculated with the use of food-frequency questionnaires. Measures of dual-energy X-ray absorptiometry-derived fat mass included the limb-to-trunk fat mass ratio (FMR), fat mass index, and central fat mass index.Results:
In cross-sectional multivariable analyses, higher intake of anthocyanins, flavonols, and proanthocyanidins were associated with a lower FMR with mean ± SE differences between extreme quintiles of -0.03 ± 0.02 (P-trend = 0.02), -0.03 ± 0.02 (P-trend = 0.03), and -0.05 ± 0.02 (P-trend < 0.01), respectively. These associations were not markedly changed after further adjustment for fiber and total fruit and vegetable intakes. In monozygotic, intake-discordant twin pairs, twins with higher intakes of flavan-3-ols (n = 154, P = 0.03), flavonols (n = 173, P = 0.03), and proanthocyanidins (n = 172, P < 0.01) had a significantly lower FMR than that of their co-twins with within-pair differences of 3-4%. Furthermore, in confirmatory food-based analyses, twins with higher intakes of flavonol-rich foods (onions, tea, and pears; P = 0.01) and proanthocyanidin-rich foods (apples and cocoa drinks; P = 0.04) and, in younger participants (aged <50 y) only, of anthocyanin-rich foods (berries, pears, grapes, and wine; P = 0.01) had a 3-9% lower FMR than that of their co-twins.Conclusions:
These data suggest that higher habitual intake of a number of flavonoids, including anthocyanins, flavan-3-ols, flavonols, and proanthocyanidins, are associated with lower fat mass independent of shared genetic and common environmental factors. Intervention trials are needed to further examine the effect of flavonoid-rich foods on body composition.Links
MeSH
Pub Type(s)
Journal Article
Twin Study
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
28100511
Citation
Jennings, Amy, et al. "Higher Dietary Flavonoid Intakes Are Associated With Lower Objectively Measured Body Composition in Women: Evidence From Discordant Monozygotic Twins." The American Journal of Clinical Nutrition, vol. 105, no. 3, 2017, pp. 626-634.
Jennings A, MacGregor A, Spector T, et al. Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins. Am J Clin Nutr. 2017;105(3):626-634.
Jennings, A., MacGregor, A., Spector, T., & Cassidy, A. (2017). Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins. The American Journal of Clinical Nutrition, 105(3), 626-634. https://doi.org/10.3945/ajcn.116.144394
Jennings A, et al. Higher Dietary Flavonoid Intakes Are Associated With Lower Objectively Measured Body Composition in Women: Evidence From Discordant Monozygotic Twins. Am J Clin Nutr. 2017;105(3):626-634. PubMed PMID: 28100511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins.
AU - Jennings,Amy,
AU - MacGregor,Alex,
AU - Spector,Tim,
AU - Cassidy,Aedín,
Y1 - 2017/01/18/
PY - 2016/08/23/received
PY - 2016/12/16/accepted
PY - 2017/1/20/pubmed
PY - 2017/6/22/medline
PY - 2017/1/20/entrez
KW - body composition
KW - diet
KW - fat distribution
KW - flavonoids
KW - twins
SP - 626
EP - 634
JF - The American journal of clinical nutrition
JO - Am J Clin Nutr
VL - 105
IS - 3
N2 - Background: Although dietary flavonoid intake has been associated with less weight gain, there are limited data on its impact on fat mass, and to our knowledge, the contribution of genetic factors to this relation has not previously been assessed.Objective: We examined the associations between flavonoid intakes and fat mass.Design: In a study of 2734 healthy, female twins aged 18-83 y from the TwinsUK registry, intakes of total flavonoids and 7 subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers, and proanthocyanidins) were calculated with the use of food-frequency questionnaires. Measures of dual-energy X-ray absorptiometry-derived fat mass included the limb-to-trunk fat mass ratio (FMR), fat mass index, and central fat mass index.Results: In cross-sectional multivariable analyses, higher intake of anthocyanins, flavonols, and proanthocyanidins were associated with a lower FMR with mean ± SE differences between extreme quintiles of -0.03 ± 0.02 (P-trend = 0.02), -0.03 ± 0.02 (P-trend = 0.03), and -0.05 ± 0.02 (P-trend < 0.01), respectively. These associations were not markedly changed after further adjustment for fiber and total fruit and vegetable intakes. In monozygotic, intake-discordant twin pairs, twins with higher intakes of flavan-3-ols (n = 154, P = 0.03), flavonols (n = 173, P = 0.03), and proanthocyanidins (n = 172, P < 0.01) had a significantly lower FMR than that of their co-twins with within-pair differences of 3-4%. Furthermore, in confirmatory food-based analyses, twins with higher intakes of flavonol-rich foods (onions, tea, and pears; P = 0.01) and proanthocyanidin-rich foods (apples and cocoa drinks; P = 0.04) and, in younger participants (aged <50 y) only, of anthocyanin-rich foods (berries, pears, grapes, and wine; P = 0.01) had a 3-9% lower FMR than that of their co-twins.Conclusions: These data suggest that higher habitual intake of a number of flavonoids, including anthocyanins, flavan-3-ols, flavonols, and proanthocyanidins, are associated with lower fat mass independent of shared genetic and common environmental factors. Intervention trials are needed to further examine the effect of flavonoid-rich foods on body composition.
SN - 1938-3207
UR - https://www.unboundmedicine.com/medline/citation/28100511/Higher_dietary_flavonoid_intakes_are_associated_with_lower_objectively_measured_body_composition_in_women:_evidence_from_discordant_monozygotic_twins_
L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.116.144394
DB - PRIME
DP - Unbound Medicine
ER -