TY - JOUR T1 - Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. AU - Rhodes,Andrew, AU - Evans,Laura E, AU - Alhazzani,Waleed, AU - Levy,Mitchell M, AU - Antonelli,Massimo, AU - Ferrer,Ricard, AU - Kumar,Anand, AU - Sevransky,Jonathan E, AU - Sprung,Charles L, AU - Nunnally,Mark E, AU - Rochwerg,Bram, AU - Rubenfeld,Gordon D, AU - Angus,Derek C, AU - Annane,Djillali, AU - Beale,Richard J, AU - Bellinghan,Geoffrey J, AU - Bernard,Gordon R, AU - Chiche,Jean-Daniel, AU - Coopersmith,Craig, AU - De Backer,Daniel P, AU - French,Craig J, AU - Fujishima,Seitaro, AU - Gerlach,Herwig, AU - Hidalgo,Jorge Luis, AU - Hollenberg,Steven M, AU - Jones,Alan E, AU - Karnad,Dilip R, AU - Kleinpell,Ruth M, AU - Koh,Younsuk, AU - Lisboa,Thiago Costa, AU - Machado,Flavia R, AU - Marini,John J, AU - Marshall,John C, AU - Mazuski,John E, AU - McIntyre,Lauralyn A, AU - McLean,Anthony S, AU - Mehta,Sangeeta, AU - Moreno,Rui P, AU - Myburgh,John, AU - Navalesi,Paolo, AU - Nishida,Osamu, AU - Osborn,Tiffany M, AU - Perner,Anders, AU - Plunkett,Colleen M, AU - Ranieri,Marco, AU - Schorr,Christa A, AU - Seckel,Maureen A, AU - Seymour,Christopher W, AU - Shieh,Lisa, AU - Shukri,Khalid A, AU - Simpson,Steven Q, AU - Singer,Mervyn, AU - Thompson,B Taylor, AU - Townsend,Sean R, AU - Van der Poll,Thomas, AU - Vincent,Jean-Louis, AU - Wiersinga,W Joost, AU - Zimmerman,Janice L, AU - Dellinger,R Phillip, Y1 - 2017/01/18/ PY - 2017/01/02/received PY - 2017/01/06/accepted PY - 2017/1/20/pubmed PY - 2017/7/22/medline PY - 2017/1/20/entrez KW - Evidence-based medicine KW - Grading of Recommendations Assessment, Development, and Evaluation criteria KW - Guidelines KW - Infection KW - Sepsis KW - Sepsis bundles KW - Sepsis syndrome KW - Septic shock KW - Surviving Sepsis Campaign SP - 304 EP - 377 JF - Intensive care medicine JO - Intensive Care Med VL - 43 IS - 3 N2 - OBJECTIVE: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012". DESIGN: A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development. METHODS: The panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable. RESULTS: The Surviving Sepsis Guideline panel provided 93 statements on early management and resuscitation of patients with sepsis or septic shock. Overall, 32 were strong recommendations, 39 were weak recommendations, and 18 were best-practice statements. No recommendation was provided for four questions. CONCLUSIONS: Substantial agreement exists among a large cohort of international experts regarding many strong recommendations for the best care of patients with sepsis. Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality. SN - 1432-1238 UR - https://www.unboundmedicine.com/medline/citation/28101605/Surviving_Sepsis_Campaign:_International_Guidelines_for_Management_of_Sepsis_and_Septic_Shock:_2016_ DB - PRIME DP - Unbound Medicine ER -