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Aortic-Radial Pulse Wave Velocity Ratio in End-stage Renal Disease Patients: Association with Age, Body Tissue Hydration Status, Renal Failure Etiology and Five Years of Hemodialysis.
High Blood Press Cardiovasc Prev. 2017 Mar; 24(1):37-48.HB

Abstract

INTRODUCTION

The etiology of the end-stage renal disease (ESRD) and the hydration status may be involved in the arterial stiffening process observed in hemodialyzed patients. The ratio between carotid-femoral and carotid-radial pulse wave velocity (PWV ratio) was recently proposed to characterize the patient-specific stiffening process.

AIMS

to analyze: (1) the PWV-ratio in healthy and hemodialyzed subjects, analyzing potential changes associated to etiologies of the ESRD, (2) the PWV-ratio and hydration status using multiple-frequency bioimpedance and, (3) the effects of hemodialysis on PWV-ratio in a 5-year follow-up.

METHODS

PWV-ratio was evaluated in 151 patients differentiated by the pathology determining their ESRD. Total body fluid (TBF), intra and extra cellular fluid (ICF, ECF) were measured in 65 of these patients using bioelectrical-impedance. The association between arterial, hemodynamic or fluid parameters was analyzed. PWV-ratio was evaluated in a group of patients (n = 25) 5 years later (follow-up study).

RESULTS

PWV-ratio increased in the ESRD cohort with respect to the control group (1.03 ± 0.23 vs. 1.31 ± 0.37; p < 0.001). PWV-ratio in the diabetic nephropathy group was higher than in all other etiological groups (1.61 ± 0.33; p < 0.05). PWV-ratio was associated with TBF (r = -0.238; p < 0.05), ICF (r = -0.323; p < 0.01), ECF/ICF (r = 0.400; p < 0.001) and ECF/TBF (r = 0.403; p < 0.001). PWV-ratio calculated in ESRD patients in 2007 increased 5 years later (1.14 ± 0.32 vs. 1.43 ± 0.44; p < 0.005).

CONCLUSIONS

PWV-ratio increased the most in patients with diabetic nephropathy. PWV ratio was significantly associated with age and body hydration status, but not with the blood pressure. PWV-ratio could be considered a blood pressure-independent parameter, associated with the age and hydration status of the patient.

Authors+Show Affiliations

Physiology Department, School of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay. dbia@fmed.edu.uy.Fresenius FME Burzaco, Av. Tomás Espora 2289, B1852FZD, Buenos Aires, Argentina.Nephrology and Dialysis Unit, Santojanni Hospital, Pilar 950, C1408INH, Buenos Aires, Argentina.Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Solís 453, C1078AAI, Buenos Aires, Argentina.Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Solís 453, C1078AAI, Buenos Aires, Argentina. Technological National University, Medrano 951, C1179AAQ, Buenos Aires, Argentina.Physiology Department, School of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay.Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Solís 453, C1078AAI, Buenos Aires, Argentina.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28102499

Citation

Bia, Daniel, et al. "Aortic-Radial Pulse Wave Velocity Ratio in End-stage Renal Disease Patients: Association With Age, Body Tissue Hydration Status, Renal Failure Etiology and Five Years of Hemodialysis." High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension, vol. 24, no. 1, 2017, pp. 37-48.
Bia D, Valtuille R, Galli C, et al. Aortic-Radial Pulse Wave Velocity Ratio in End-stage Renal Disease Patients: Association with Age, Body Tissue Hydration Status, Renal Failure Etiology and Five Years of Hemodialysis. High Blood Press Cardiovasc Prev. 2017;24(1):37-48.
Bia, D., Valtuille, R., Galli, C., Wray, S., Armentano, R., Zócalo, Y., & Cabrera-Fischer, E. (2017). Aortic-Radial Pulse Wave Velocity Ratio in End-stage Renal Disease Patients: Association with Age, Body Tissue Hydration Status, Renal Failure Etiology and Five Years of Hemodialysis. High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension, 24(1), 37-48. https://doi.org/10.1007/s40292-017-0178-3
Bia D, et al. Aortic-Radial Pulse Wave Velocity Ratio in End-stage Renal Disease Patients: Association With Age, Body Tissue Hydration Status, Renal Failure Etiology and Five Years of Hemodialysis. High Blood Press Cardiovasc Prev. 2017;24(1):37-48. PubMed PMID: 28102499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aortic-Radial Pulse Wave Velocity Ratio in End-stage Renal Disease Patients: Association with Age, Body Tissue Hydration Status, Renal Failure Etiology and Five Years of Hemodialysis. AU - Bia,Daniel, AU - Valtuille,Rodolfo, AU - Galli,Cintia, AU - Wray,Sandra, AU - Armentano,Ricardo, AU - Zócalo,Yanina, AU - Cabrera-Fischer,Edmundo, Y1 - 2017/01/19/ PY - 2016/11/21/received PY - 2017/01/05/accepted PY - 2017/1/20/pubmed PY - 2017/9/7/medline PY - 2017/1/20/entrez KW - Arterial stiffness KW - Body hydration status KW - Hemodialysis KW - Pulse wave velocity ratio SP - 37 EP - 48 JF - High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension JO - High Blood Press Cardiovasc Prev VL - 24 IS - 1 N2 - INTRODUCTION: The etiology of the end-stage renal disease (ESRD) and the hydration status may be involved in the arterial stiffening process observed in hemodialyzed patients. The ratio between carotid-femoral and carotid-radial pulse wave velocity (PWV ratio) was recently proposed to characterize the patient-specific stiffening process. AIMS: to analyze: (1) the PWV-ratio in healthy and hemodialyzed subjects, analyzing potential changes associated to etiologies of the ESRD, (2) the PWV-ratio and hydration status using multiple-frequency bioimpedance and, (3) the effects of hemodialysis on PWV-ratio in a 5-year follow-up. METHODS: PWV-ratio was evaluated in 151 patients differentiated by the pathology determining their ESRD. Total body fluid (TBF), intra and extra cellular fluid (ICF, ECF) were measured in 65 of these patients using bioelectrical-impedance. The association between arterial, hemodynamic or fluid parameters was analyzed. PWV-ratio was evaluated in a group of patients (n = 25) 5 years later (follow-up study). RESULTS: PWV-ratio increased in the ESRD cohort with respect to the control group (1.03 ± 0.23 vs. 1.31 ± 0.37; p < 0.001). PWV-ratio in the diabetic nephropathy group was higher than in all other etiological groups (1.61 ± 0.33; p < 0.05). PWV-ratio was associated with TBF (r = -0.238; p < 0.05), ICF (r = -0.323; p < 0.01), ECF/ICF (r = 0.400; p < 0.001) and ECF/TBF (r = 0.403; p < 0.001). PWV-ratio calculated in ESRD patients in 2007 increased 5 years later (1.14 ± 0.32 vs. 1.43 ± 0.44; p < 0.005). CONCLUSIONS: PWV-ratio increased the most in patients with diabetic nephropathy. PWV ratio was significantly associated with age and body hydration status, but not with the blood pressure. PWV-ratio could be considered a blood pressure-independent parameter, associated with the age and hydration status of the patient. SN - 1179-1985 UR - https://www.unboundmedicine.com/medline/citation/28102499/Aortic_Radial_Pulse_Wave_Velocity_Ratio_in_End_stage_Renal_Disease_Patients:_Association_with_Age_Body_Tissue_Hydration_Status_Renal_Failure_Etiology_and_Five_Years_of_Hemodialysis_ L2 - https://dx.doi.org/10.1007/s40292-017-0178-3 DB - PRIME DP - Unbound Medicine ER -