Tags

Type your tag names separated by a space and hit enter

Optical Coherence Tomography Reveals Retinal Neuroaxonal Thinning in Frontotemporal Dementia as in Alzheimer's Disease.
J Alzheimers Dis. 2017; 56(3):1101-1107.JA

Abstract

BACKGROUND

Alzheimer's disease (AD) and frontotemporal dementia (FTD) are leading causes of cognitive decline. Optical coherence tomography (OCT) allows the measurement of thickness of retinal neuroaxonal layers. While in AD and mild cognitive impairment (MCI), retinal nerve fiber layer (RNFL) thinning is frequently reported, less information is available on ganglion cell layer-inner plexiform layer (GCL-IPL). Data on FTD are lacking.

OBJECTIVE

To obtain cross-sectional information on RNFL and GCL-IPL thickness among MCI, AD, FTD, and healthy controls (HC), and their correlations with dementia severity.

METHODS

Peripapillary OCT scans were obtained in 27 MCI, 39 AD, 17 FTD, 49 HC using high-definition Heidelberg Spectral-domain OCT, with RNFL and GCL-IPL thickness measurement. Statistical analysis tested group effects and correlation with gender, disease duration and severity (Mini-Mental State Examination, MMSE).

RESULTS

RNFL showed a significant group effect [F(4,132) = 3.786, p = 0.006], being reduced versus controls in MCI (p = 0.033), moderate AD (p = 0.025), and FTD (p < 0.001), and versus mild AD in FTD (p = 0.042). GCL-IPL showed a significant group effect as well [F(4,121) = 5.104, p < 0.001], with reduction in moderate AD versus HC (p < 0.001), MCI (p = 0.037), and mild AD (p = 0.009); in FTD versus HC (p = 0.002) and mild AD (p = 0.038). In AD, GCL-IPL correlated with MMSE (r = 0.487, p = 0.003), without significant effects of age, gender, or disease duration.

CONCLUSION

Retinal neuroaxonal thinning occurs in MCI/AD consistently with previous reports, as well as in FTD. Correlation with disease severity in AD suggests that retinal and brain neurodegeneration may occur in parallel to some extent, and prompts larger studies aimed at providing surrogate endpoints for clinical trials in AD.

Authors+Show Affiliations

Department of Neurology and INSPE - Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.University Vita-Salute San Raffaele Milan, Italy.Department of Neurology and INSPE - Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy.University Vita-Salute San Raffaele Milan, Italy.Department of Neurology and INSPE - Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy. University Vita-Salute San Raffaele Milan, Italy.Department of Neurology and INSPE - Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy. University Vita-Salute San Raffaele Milan, Italy.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28106555

Citation

Ferrari, Laura, et al. "Optical Coherence Tomography Reveals Retinal Neuroaxonal Thinning in Frontotemporal Dementia as in Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 56, no. 3, 2017, pp. 1101-1107.
Ferrari L, Huang SC, Magnani G, et al. Optical Coherence Tomography Reveals Retinal Neuroaxonal Thinning in Frontotemporal Dementia as in Alzheimer's Disease. J Alzheimers Dis. 2017;56(3):1101-1107.
Ferrari, L., Huang, S. C., Magnani, G., Ambrosi, A., Comi, G., & Leocani, L. (2017). Optical Coherence Tomography Reveals Retinal Neuroaxonal Thinning in Frontotemporal Dementia as in Alzheimer's Disease. Journal of Alzheimer's Disease : JAD, 56(3), 1101-1107. https://doi.org/10.3233/JAD-160886
Ferrari L, et al. Optical Coherence Tomography Reveals Retinal Neuroaxonal Thinning in Frontotemporal Dementia as in Alzheimer's Disease. J Alzheimers Dis. 2017;56(3):1101-1107. PubMed PMID: 28106555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optical Coherence Tomography Reveals Retinal Neuroaxonal Thinning in Frontotemporal Dementia as in Alzheimer's Disease. AU - Ferrari,Laura, AU - Huang,Su-Chun, AU - Magnani,Giuseppe, AU - Ambrosi,Alessandro, AU - Comi,Giancarlo, AU - Leocani,Letizia, PY - 2017/1/21/pubmed PY - 2018/2/22/medline PY - 2017/1/21/entrez KW - Alzheimer’s disease KW - frontotemporal dementia KW - ganglion cell layer KW - optical coherence tomography KW - retinal nerve fiber layer SP - 1101 EP - 1107 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 56 IS - 3 N2 - BACKGROUND: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are leading causes of cognitive decline. Optical coherence tomography (OCT) allows the measurement of thickness of retinal neuroaxonal layers. While in AD and mild cognitive impairment (MCI), retinal nerve fiber layer (RNFL) thinning is frequently reported, less information is available on ganglion cell layer-inner plexiform layer (GCL-IPL). Data on FTD are lacking. OBJECTIVE: To obtain cross-sectional information on RNFL and GCL-IPL thickness among MCI, AD, FTD, and healthy controls (HC), and their correlations with dementia severity. METHODS: Peripapillary OCT scans were obtained in 27 MCI, 39 AD, 17 FTD, 49 HC using high-definition Heidelberg Spectral-domain OCT, with RNFL and GCL-IPL thickness measurement. Statistical analysis tested group effects and correlation with gender, disease duration and severity (Mini-Mental State Examination, MMSE). RESULTS: RNFL showed a significant group effect [F(4,132) = 3.786, p = 0.006], being reduced versus controls in MCI (p = 0.033), moderate AD (p = 0.025), and FTD (p < 0.001), and versus mild AD in FTD (p = 0.042). GCL-IPL showed a significant group effect as well [F(4,121) = 5.104, p < 0.001], with reduction in moderate AD versus HC (p < 0.001), MCI (p = 0.037), and mild AD (p = 0.009); in FTD versus HC (p = 0.002) and mild AD (p = 0.038). In AD, GCL-IPL correlated with MMSE (r = 0.487, p = 0.003), without significant effects of age, gender, or disease duration. CONCLUSION: Retinal neuroaxonal thinning occurs in MCI/AD consistently with previous reports, as well as in FTD. Correlation with disease severity in AD suggests that retinal and brain neurodegeneration may occur in parallel to some extent, and prompts larger studies aimed at providing surrogate endpoints for clinical trials in AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/28106555/Optical_Coherence_Tomography_Reveals_Retinal_Neuroaxonal_Thinning_in_Frontotemporal_Dementia_as_in_Alzheimer's_Disease_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JAD-160886 DB - PRIME DP - Unbound Medicine ER -