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[An unclassifiable case of hypoplastic leukemia in old age treated successfully with vincristine and prednisolone].
Rinsho Ketsueki. 1989 Jul; 30(7):1042-6.RK

Abstract

An 80-year-old male was admitted because of dizziness and palpitation. Laboratory investigation revealed pancytopenia. A bone marrow aspirate showed a markedly hypocellular marrow with 41.6% blast cells. Peroxidase activity was negative and PAS reaction was block positive in the blast cells. Surface markers of these cells were positive for HLA-DR antigen and partially positive for CD13 (MY7). Other markers, such as T, B or myeloid antigens were all negative. These blast cells were classified as L1 according to the FAB system but suggested essentially unclassifiable in cell differentiation. The patient was treated successfully with vincristine and prednisolone and induced into complete remission although repeated marrow examination findings revealed hypocellular. As for the classification of hypoplastic leukemia, lymphoid or primitive "stem cell" leukemia also should be considered as other categories of acute leukemias and be treated according to each case.

Authors

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Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

2810788

Citation

Shimada, H, et al. "[An Unclassifiable Case of Hypoplastic Leukemia in Old Age Treated Successfully With Vincristine and Prednisolone]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 30, no. 7, 1989, pp. 1042-6.
Shimada H, Kainouchi M, Shiomura T, et al. [An unclassifiable case of hypoplastic leukemia in old age treated successfully with vincristine and prednisolone]. Rinsho Ketsueki. 1989;30(7):1042-6.
Shimada, H., Kainouchi, M., Shiomura, T., & Obara, H. (1989). [An unclassifiable case of hypoplastic leukemia in old age treated successfully with vincristine and prednisolone]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 30(7), 1042-6.
Shimada H, et al. [An Unclassifiable Case of Hypoplastic Leukemia in Old Age Treated Successfully With Vincristine and Prednisolone]. Rinsho Ketsueki. 1989;30(7):1042-6. PubMed PMID: 2810788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [An unclassifiable case of hypoplastic leukemia in old age treated successfully with vincristine and prednisolone]. AU - Shimada,H, AU - Kainouchi,M, AU - Shiomura,T, AU - Obara,H, PY - 1989/7/1/pubmed PY - 1989/7/1/medline PY - 1989/7/1/entrez SP - 1042 EP - 6 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 30 IS - 7 N2 - An 80-year-old male was admitted because of dizziness and palpitation. Laboratory investigation revealed pancytopenia. A bone marrow aspirate showed a markedly hypocellular marrow with 41.6% blast cells. Peroxidase activity was negative and PAS reaction was block positive in the blast cells. Surface markers of these cells were positive for HLA-DR antigen and partially positive for CD13 (MY7). Other markers, such as T, B or myeloid antigens were all negative. These blast cells were classified as L1 according to the FAB system but suggested essentially unclassifiable in cell differentiation. The patient was treated successfully with vincristine and prednisolone and induced into complete remission although repeated marrow examination findings revealed hypocellular. As for the classification of hypoplastic leukemia, lymphoid or primitive "stem cell" leukemia also should be considered as other categories of acute leukemias and be treated according to each case. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/2810788/[An_unclassifiable_case_of_hypoplastic_leukemia_in_old_age_treated_successfully_with_vincristine_and_prednisolone]_ L2 - https://medlineplus.gov/leukemia.html DB - PRIME DP - Unbound Medicine ER -