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Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study.
Behav Brain Res 2017; 322(Pt A):100-109BB

Abstract

Apolipoprotein E (APOE) ε4 allele is the genetic risk factor with the most established evidence for sporadic Alzheimer's disease. Previous neuroimaging studies have demonstrated insufficiently consistent functional and structural changes among healthy APOE ε4 carriers when compared to non-carriers. Here, in a cognitively intact elderly group (a total of 110: 45 APOE ε4 carriers, 65 non-carriers), we aimed to investigate the potential role of APOE ε4 in the modulation of grey matter activity, white matter integrity, and brain morphology before the development of clinically significant symptoms and signs, by methods of: amplitude of low frequency fluctuations and regional homogeneity analysis based on resting state fMRI, and fiber tractography approach based on diffusion tensor imaging. Our results revealed that compared to non-carriers, APOE ε4 carriers showed: (1) an inconsistent pattern of activity change in the default mode network, including increased gray matter activity in anterior cingulate cortex and medial prefrontal cortex and decreased activity in precuneus; (2) lower mean diffusivity (MD) in fibers of corona radiata and corpus callosum, and lower axial diffusivity in genu of corpus callosum; and (3) significant positive correlation between the MD value of the right superior corona radiate and gross white matter volume; significant negative correlation between the MD value of the right superior corona radiate and Mini-Mental State Examination (MMSE) score. Our results suggested that APOE ε4 gene can modulate gray matter activity and white matter integrity in cognitive and memory related regions, even before any clinical or neuropsychic symtoms or signs of imminent disease.

Authors+Show Affiliations

School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China.Department of Medical Biotechnology, Dongguk University, 21 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea.School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China.The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China.MGB, 291, Harmony-ro, Yeonsu-gu, Incheon, Republic of Korea.EDGC, 291, Harmony-ro, Yeonsu-gu, Incheon, Republic of Korea.School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China. Electronic address: huangly@mail.xidian.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28108320

Citation

Cai, Suping, et al. "Modulation On Brain Gray Matter Activity and White Matter Integrity By APOE Ε4 Risk Gene in Cognitively Intact Elderly: a Multimodal Neuroimaging Study." Behavioural Brain Research, vol. 322, no. Pt A, 2017, pp. 100-109.
Cai S, Jiang Y, Wang Y, et al. Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study. Behav Brain Res. 2017;322(Pt A):100-109.
Cai, S., Jiang, Y., Wang, Y., Wu, X., Ren, J., Lee, M. S., ... Huang, L. (2017). Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study. Behavioural Brain Research, 322(Pt A), pp. 100-109. doi:10.1016/j.bbr.2017.01.027.
Cai S, et al. Modulation On Brain Gray Matter Activity and White Matter Integrity By APOE Ε4 Risk Gene in Cognitively Intact Elderly: a Multimodal Neuroimaging Study. Behav Brain Res. 2017 03 30;322(Pt A):100-109. PubMed PMID: 28108320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study. AU - Cai,Suping, AU - Jiang,Yuanyuan, AU - Wang,Yubo, AU - Wu,Xiaoming, AU - Ren,Junchan, AU - Lee,Min Seob, AU - Lee,Sunghoon, AU - Huang,Liyu, Y1 - 2017/01/17/ PY - 2016/10/31/received PY - 2017/01/11/revised PY - 2017/01/13/accepted PY - 2017/1/22/pubmed PY - 2017/12/2/medline PY - 2017/1/22/entrez KW - APOE ε4 KW - Alzheimer’s disease KW - Cognitively intact elderly KW - DTI KW - Gray matter activity KW - MRI KW - White matter integrity KW - fMRI SP - 100 EP - 109 JF - Behavioural brain research JO - Behav. Brain Res. VL - 322 IS - Pt A N2 - Apolipoprotein E (APOE) ε4 allele is the genetic risk factor with the most established evidence for sporadic Alzheimer's disease. Previous neuroimaging studies have demonstrated insufficiently consistent functional and structural changes among healthy APOE ε4 carriers when compared to non-carriers. Here, in a cognitively intact elderly group (a total of 110: 45 APOE ε4 carriers, 65 non-carriers), we aimed to investigate the potential role of APOE ε4 in the modulation of grey matter activity, white matter integrity, and brain morphology before the development of clinically significant symptoms and signs, by methods of: amplitude of low frequency fluctuations and regional homogeneity analysis based on resting state fMRI, and fiber tractography approach based on diffusion tensor imaging. Our results revealed that compared to non-carriers, APOE ε4 carriers showed: (1) an inconsistent pattern of activity change in the default mode network, including increased gray matter activity in anterior cingulate cortex and medial prefrontal cortex and decreased activity in precuneus; (2) lower mean diffusivity (MD) in fibers of corona radiata and corpus callosum, and lower axial diffusivity in genu of corpus callosum; and (3) significant positive correlation between the MD value of the right superior corona radiate and gross white matter volume; significant negative correlation between the MD value of the right superior corona radiate and Mini-Mental State Examination (MMSE) score. Our results suggested that APOE ε4 gene can modulate gray matter activity and white matter integrity in cognitive and memory related regions, even before any clinical or neuropsychic symtoms or signs of imminent disease. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/28108320/Modulation_on_brain_gray_matter_activity_and_white_matter_integrity_by_APOE_ε4_risk_gene_in_cognitively_intact_elderly:_A_multimodal_neuroimaging_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(16)30961-5 DB - PRIME DP - Unbound Medicine ER -