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Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis.
Vet Pathol. 2017 05; 54(3):511-519.VP

Abstract

Canine chronic ulcerative stomatitis, also known as chronic ulcerative paradental stomatitis, is a painful condition of the oral cavity. The purpose of this study was to determine if there are commonalities in clinical and radiographic features among patients, whether the histopathologic evaluation might inform the pathogenesis, and whether the condition appears similar to human oral mucosal diseases. To do this, we prospectively collected clinical, radiographic, and histopathologic data from 20 dogs diagnosed with the disease. Clinical data were based on a clinical disease activity index, oral and periodontal examination parameters, and full-mouth dental radiographs. The histopathological and immunohistochemical data were based on oral mucosal samples obtained from erosive or ulcerated areas. Our findings revealed that canine chronic stomatitis is clinically characterized by painful oral mucosal ulcers of varying size, pattern, appearance, and distribution, most often associated with teeth with early periodontitis. Histologic examination revealed a subepithelial lichenoid band (interface mucositis) where B cells, T cells, and Forkhead-box protein 3 (FoxP3)- and interleukin-17-expressing cells were present. These cells might play a role in the underlying immune response and an immune-mediated pathogenesis is suspected. The clinical and histopathologic features of this chronic inflammatory mucosal disease in dogs resemble those of oral lichen planus in humans.

Authors+Show Affiliations

1 Sacramento Veterinary Dental Services, Rancho Cordova, CA, USA.2 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.3 Department of Pathology, Microbiology and Immunology, University of California, Davis, School of Veterinary Medicine, Davis, CA, USA.4 Department of Analytic Epidemiology, School of Veterinary Medicine and School of Medicine, University of California, Davis, CA, USA.3 Department of Pathology, Microbiology and Immunology, University of California, Davis, School of Veterinary Medicine, Davis, CA, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28113036

Citation

Anderson, J G., et al. "Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis." Veterinary Pathology, vol. 54, no. 3, 2017, pp. 511-519.
Anderson JG, Peralta S, Kol A, et al. Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis. Vet Pathol. 2017;54(3):511-519.
Anderson, J. G., Peralta, S., Kol, A., Kass, P. H., & Murphy, B. (2017). Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis. Veterinary Pathology, 54(3), 511-519. https://doi.org/10.1177/0300985816688754
Anderson JG, et al. Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis. Vet Pathol. 2017;54(3):511-519. PubMed PMID: 28113036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis. AU - Anderson,J G, AU - Peralta,S, AU - Kol,A, AU - Kass,P H, AU - Murphy,B, Y1 - 2017/01/23/ PY - 2017/1/24/pubmed PY - 2017/11/14/medline PY - 2017/1/24/entrez KW - FoxP3 KW - IL-17 KW - canine chronic ulcerative stomatitis KW - dentistry KW - histopathology KW - immune-mediated disease KW - oral cavity SP - 511 EP - 519 JF - Veterinary pathology JO - Vet. Pathol. VL - 54 IS - 3 N2 - Canine chronic ulcerative stomatitis, also known as chronic ulcerative paradental stomatitis, is a painful condition of the oral cavity. The purpose of this study was to determine if there are commonalities in clinical and radiographic features among patients, whether the histopathologic evaluation might inform the pathogenesis, and whether the condition appears similar to human oral mucosal diseases. To do this, we prospectively collected clinical, radiographic, and histopathologic data from 20 dogs diagnosed with the disease. Clinical data were based on a clinical disease activity index, oral and periodontal examination parameters, and full-mouth dental radiographs. The histopathological and immunohistochemical data were based on oral mucosal samples obtained from erosive or ulcerated areas. Our findings revealed that canine chronic stomatitis is clinically characterized by painful oral mucosal ulcers of varying size, pattern, appearance, and distribution, most often associated with teeth with early periodontitis. Histologic examination revealed a subepithelial lichenoid band (interface mucositis) where B cells, T cells, and Forkhead-box protein 3 (FoxP3)- and interleukin-17-expressing cells were present. These cells might play a role in the underlying immune response and an immune-mediated pathogenesis is suspected. The clinical and histopathologic features of this chronic inflammatory mucosal disease in dogs resemble those of oral lichen planus in humans. SN - 1544-2217 UR - https://www.unboundmedicine.com/medline/citation/28113036/Clinical_and_Histopathologic_Characterization_of_Canine_Chronic_Ulcerative_Stomatitis L2 - http://journals.sagepub.com/doi/full/10.1177/0300985816688754?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -