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Induction of apoptosis and DNA damage by 4-nonylphenol in African catfish (Clarias gariepinus) and the antioxidant role of Cydonia oblonga.
Ecotoxicol Environ Saf. 2017 May; 139:97-101.EE

Abstract

In this study, we assessed the toxic effects of sub lethal concentration (0.1mgl-1) 4-nonylphenol (4-NP) on serum biochemical parameters, liver lipid peroxidation (LPO) and antioxidant enzymes of the African catfish Clarias gariepinus for 14 days and the ability of the quince leaf extract to alleviate the effects of (4-NP). Fish were categorized into four groups: control, exposure to 0.1mgl-1 4-NP, exposure to 0.1mgl-1 4-NP with quince leaf extract (10ml/30L water), and exposure to 0.1mgl-1 4-NP with quince leaf extract (20ml/30L water). 4-NP exposure induced a significant (p<0.05) increase in the levels of glucose, AST, ALT, creatinine, urea, uric acid, cholesterol, and G6PDH as well as, the percentages of hepatic LPO level, DNA fragmentation, and apoptotic erythrocytes (p<0.05). A significant (p<0.05) decrease in alkaline phosphatase (ALP), total protein, albumin, globulin, total lipids, and LDH were also recorded. Liver enzyme activities (SOD, CAT and TAC) were increased. Addition of the quince leaf extract into the water was able to reinstate the alterations in biochemical parameters, antioxidant biomarkers, apoptotic level and hepatic DNA damage induced by 4-NP.

Authors+Show Affiliations

Department of Zoology, Faculty of Science, Assiut University, Assiut, Egypt. Electronic address: alaa_h254@yahoo.com.Department of Zoology, Faculty of women for Arts, Science & Education, Ain Shams University, Cairo, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28113117

Citation

Sayed, Alaa El-Din H., and Heba S. Hamed. "Induction of Apoptosis and DNA Damage By 4-nonylphenol in African Catfish (Clarias Gariepinus) and the Antioxidant Role of Cydonia Oblonga." Ecotoxicology and Environmental Safety, vol. 139, 2017, pp. 97-101.
Sayed AE, Hamed HS. Induction of apoptosis and DNA damage by 4-nonylphenol in African catfish (Clarias gariepinus) and the antioxidant role of Cydonia oblonga. Ecotoxicol Environ Saf. 2017;139:97-101.
Sayed, A. E., & Hamed, H. S. (2017). Induction of apoptosis and DNA damage by 4-nonylphenol in African catfish (Clarias gariepinus) and the antioxidant role of Cydonia oblonga. Ecotoxicology and Environmental Safety, 139, 97-101. https://doi.org/10.1016/j.ecoenv.2017.01.024
Sayed AE, Hamed HS. Induction of Apoptosis and DNA Damage By 4-nonylphenol in African Catfish (Clarias Gariepinus) and the Antioxidant Role of Cydonia Oblonga. Ecotoxicol Environ Saf. 2017;139:97-101. PubMed PMID: 28113117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of apoptosis and DNA damage by 4-nonylphenol in African catfish (Clarias gariepinus) and the antioxidant role of Cydonia oblonga. AU - Sayed,Alaa El-Din H, AU - Hamed,Heba S, PY - 2016/09/20/received PY - 2017/01/12/revised PY - 2017/01/13/accepted PY - 2017/1/24/pubmed PY - 2017/6/1/medline PY - 2017/1/24/entrez KW - 4- Nonylphenol KW - Biochemistry KW - Catfish KW - DNA KW - Oxidative stress KW - Quince SP - 97 EP - 101 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 139 N2 - In this study, we assessed the toxic effects of sub lethal concentration (0.1mgl-1) 4-nonylphenol (4-NP) on serum biochemical parameters, liver lipid peroxidation (LPO) and antioxidant enzymes of the African catfish Clarias gariepinus for 14 days and the ability of the quince leaf extract to alleviate the effects of (4-NP). Fish were categorized into four groups: control, exposure to 0.1mgl-1 4-NP, exposure to 0.1mgl-1 4-NP with quince leaf extract (10ml/30L water), and exposure to 0.1mgl-1 4-NP with quince leaf extract (20ml/30L water). 4-NP exposure induced a significant (p<0.05) increase in the levels of glucose, AST, ALT, creatinine, urea, uric acid, cholesterol, and G6PDH as well as, the percentages of hepatic LPO level, DNA fragmentation, and apoptotic erythrocytes (p<0.05). A significant (p<0.05) decrease in alkaline phosphatase (ALP), total protein, albumin, globulin, total lipids, and LDH were also recorded. Liver enzyme activities (SOD, CAT and TAC) were increased. Addition of the quince leaf extract into the water was able to reinstate the alterations in biochemical parameters, antioxidant biomarkers, apoptotic level and hepatic DNA damage induced by 4-NP. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/28113117/Induction_of_apoptosis_and_DNA_damage_by_4_nonylphenol_in_African_catfish__Clarias_gariepinus__and_the_antioxidant_role_of_Cydonia_oblonga_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-6513(17)30023-4 DB - PRIME DP - Unbound Medicine ER -