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Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion.
Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):30-34.IO

Abstract

Purpose

To evaluate the changes in foveal avascular zone (FAZ) area and the retinal capillary density after a single intravitreal anti-VEGF injection for macular edema secondary to diabetic retinopathy or retinal vein occlusion.

Methods

In this prospective noncomparative case series, 18 eyes of 15 patients with diabetic macular edema (13 eyes) or macular edema secondary to central retinal vein occlusion (5 eyes) were included. Optical coherence tomography angiography (OCTA) images were obtained, and retinal capillary vessel density and FAZ area were measured in the foveal and parafoveal regions at the level of the superficial (SCP) and deep retinal capillary plexus (DCP) before and at the first visit after intravitreal injection.

Results

The mean interval between baseline and follow up OCTA was 32.5 ± 9.4 (range, 21-50) days. Foveal and parafoveal vessel density in the SCP and DCP were not significantly different before and after intravitreal injection (all P > 0.1), nor was FAZ area (P = 0.48 and P = 0.42, respectively). No significant difference was found between eyes with diabetic macular edema and those with retinal vein occlusion with respect to the mean change of vessel density and FAZ area (all P > 0.05).

Conclusions

In this pilot study, retinal capillary density and FAZ area remained statistically unchanged in the short-term after a single intravitreal injection of an anti-VEGF agent.

Authors+Show Affiliations

Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 2Doheny Eye Institute, University of California Los Angeles, Los Angeles, California, United States 3Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 4Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States.Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 4Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States.Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 4Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States.Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 2Doheny Eye Institute, University of California Los Angeles, Los Angeles, California, United States.Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States 4Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States 5Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28114569

Citation

Ghasemi Falavarjani, Khalil, et al. "Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion." Investigative Ophthalmology & Visual Science, vol. 58, no. 1, 2017, pp. 30-34.
Ghasemi Falavarjani K, Iafe NA, Hubschman JP, et al. Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion. Invest Ophthalmol Vis Sci. 2017;58(1):30-34.
Ghasemi Falavarjani, K., Iafe, N. A., Hubschman, J. P., Tsui, I., Sadda, S. R., & Sarraf, D. (2017). Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion. Investigative Ophthalmology & Visual Science, 58(1), 30-34. https://doi.org/10.1167/iovs.16-20579
Ghasemi Falavarjani K, et al. Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion. Invest Ophthalmol Vis Sci. 2017 01 1;58(1):30-34. PubMed PMID: 28114569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion. AU - Ghasemi Falavarjani,Khalil, AU - Iafe,Nicholas A, AU - Hubschman,Jean-Pierre, AU - Tsui,Irena, AU - Sadda,Srinivas R, AU - Sarraf,David, PY - 2017/1/24/entrez PY - 2017/1/24/pubmed PY - 2017/6/22/medline SP - 30 EP - 34 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 58 IS - 1 N2 - Purpose: To evaluate the changes in foveal avascular zone (FAZ) area and the retinal capillary density after a single intravitreal anti-VEGF injection for macular edema secondary to diabetic retinopathy or retinal vein occlusion. Methods: In this prospective noncomparative case series, 18 eyes of 15 patients with diabetic macular edema (13 eyes) or macular edema secondary to central retinal vein occlusion (5 eyes) were included. Optical coherence tomography angiography (OCTA) images were obtained, and retinal capillary vessel density and FAZ area were measured in the foveal and parafoveal regions at the level of the superficial (SCP) and deep retinal capillary plexus (DCP) before and at the first visit after intravitreal injection. Results: The mean interval between baseline and follow up OCTA was 32.5 ± 9.4 (range, 21-50) days. Foveal and parafoveal vessel density in the SCP and DCP were not significantly different before and after intravitreal injection (all P > 0.1), nor was FAZ area (P = 0.48 and P = 0.42, respectively). No significant difference was found between eyes with diabetic macular edema and those with retinal vein occlusion with respect to the mean change of vessel density and FAZ area (all P > 0.05). Conclusions: In this pilot study, retinal capillary density and FAZ area remained statistically unchanged in the short-term after a single intravitreal injection of an anti-VEGF agent. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/28114569/Optical_Coherence_Tomography_Angiography_Analysis_of_the_Foveal_Avascular_Zone_and_Macular_Vessel_Density_After_Anti_VEGF_Therapy_in_Eyes_With_Diabetic_Macular_Edema_and_Retinal_Vein_Occlusion_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.16-20579 DB - PRIME DP - Unbound Medicine ER -