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Antioxidant Activity and Inhibitory Potential of Cistus salviifolius (L.) and Cistus monspeliensis (L.) Aerial Parts Extracts against Key Enzymes Linked to Hyperglycemia.
Biomed Res Int. 2017; 2017:2789482.BR

Abstract

Cistus genus (Cistaceae) comprises several medicinal plants used in traditional medicines to treat several pathological conditions including hyperglycemia. These include Cistus salviifolius L. (CS) and Cistus monspeliensis L. (CM), still not fully explored as a source of metabolites with therapeutic potential for human diseases. In this study, the antioxidant α-amylase and α-glucosidase enzyme inhibitory effects of aqueous and hydromethanolic extracts from the aerial parts of Moroccan CS and CM were investigated. Antioxidant activity has been assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radicals and ferric reducing/antioxidant power (FRAP) methods. The α-amylase and α-glucosidase inhibitory activity has been assessed using an in vitro model. Moreover, mineral and phenolic contents of CS and CM were analyzed. The extracts of both species exhibited potent antioxidant activity in all used systems and possess strong inhibitory effect towards α-glucosidase (IC50: 0.95 ± 0.14 to 14.58 ± 1.26 μg/mL) and significant inhibitory potential against α-amylase (IC50: 217.10 ± 0.15 to 886.10 ± 0.10 μg/mL). Furthermore, the result showed high levels of phenolic content and unexpectedly some higher levels of mineral content in CS. The results suggest that the phenolic rich extracts of CS and CM may have a therapeutic potential against diseases associated with oxidative stress and may be useful in the management of hyperglycemia in diabetic patients.

Authors+Show Affiliations

Faculté de Médecine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie, l'Équipe de Pharmacocinétique, Mohammed V University in Rabat, BP 6203, Rabat Instituts, Rabat, Morocco.Faculté de Médecine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie, l'Équipe de Pharmacocinétique, Mohammed V University in Rabat, BP 6203, Rabat Instituts, Rabat, Morocco.Faculté de Médecine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie, l'Équipe de Pharmacocinétique, Mohammed V University in Rabat, BP 6203, Rabat Instituts, Rabat, Morocco.Faculté de Médecine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie, l'Équipe de Pharmacocinétique, Mohammed V University in Rabat, BP 6203, Rabat Instituts, Rabat, Morocco.Faculté de Médecine et de Pharmacie, Laboratoire de Pharmacologie et Toxicologie, l'Équipe de Pharmacocinétique, Mohammed V University in Rabat, BP 6203, Rabat Instituts, Rabat, Morocco.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28116307

Citation

Sayah, Karima, et al. "Antioxidant Activity and Inhibitory Potential of Cistus Salviifolius (L.) and Cistus Monspeliensis (L.) Aerial Parts Extracts Against Key Enzymes Linked to Hyperglycemia." BioMed Research International, vol. 2017, 2017, p. 2789482.
Sayah K, Marmouzi I, Naceiri Mrabti H, et al. Antioxidant Activity and Inhibitory Potential of Cistus salviifolius (L.) and Cistus monspeliensis (L.) Aerial Parts Extracts against Key Enzymes Linked to Hyperglycemia. Biomed Res Int. 2017;2017:2789482.
Sayah, K., Marmouzi, I., Naceiri Mrabti, H., Cherrah, Y., & Faouzi, M. E. (2017). Antioxidant Activity and Inhibitory Potential of Cistus salviifolius (L.) and Cistus monspeliensis (L.) Aerial Parts Extracts against Key Enzymes Linked to Hyperglycemia. BioMed Research International, 2017, 2789482. https://doi.org/10.1155/2017/2789482
Sayah K, et al. Antioxidant Activity and Inhibitory Potential of Cistus Salviifolius (L.) and Cistus Monspeliensis (L.) Aerial Parts Extracts Against Key Enzymes Linked to Hyperglycemia. Biomed Res Int. 2017;2017:2789482. PubMed PMID: 28116307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant Activity and Inhibitory Potential of Cistus salviifolius (L.) and Cistus monspeliensis (L.) Aerial Parts Extracts against Key Enzymes Linked to Hyperglycemia. AU - Sayah,Karima, AU - Marmouzi,Ilias, AU - Naceiri Mrabti,Hanae, AU - Cherrah,Yahia, AU - Faouzi,My El Abbes, Y1 - 2017/01/01/ PY - 2016/08/21/received PY - 2016/11/20/revised PY - 2016/12/12/accepted PY - 2017/1/25/entrez PY - 2017/1/25/pubmed PY - 2017/3/21/medline SP - 2789482 EP - 2789482 JF - BioMed research international JO - Biomed Res Int VL - 2017 N2 - Cistus genus (Cistaceae) comprises several medicinal plants used in traditional medicines to treat several pathological conditions including hyperglycemia. These include Cistus salviifolius L. (CS) and Cistus monspeliensis L. (CM), still not fully explored as a source of metabolites with therapeutic potential for human diseases. In this study, the antioxidant α-amylase and α-glucosidase enzyme inhibitory effects of aqueous and hydromethanolic extracts from the aerial parts of Moroccan CS and CM were investigated. Antioxidant activity has been assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radicals and ferric reducing/antioxidant power (FRAP) methods. The α-amylase and α-glucosidase inhibitory activity has been assessed using an in vitro model. Moreover, mineral and phenolic contents of CS and CM were analyzed. The extracts of both species exhibited potent antioxidant activity in all used systems and possess strong inhibitory effect towards α-glucosidase (IC50: 0.95 ± 0.14 to 14.58 ± 1.26 μg/mL) and significant inhibitory potential against α-amylase (IC50: 217.10 ± 0.15 to 886.10 ± 0.10 μg/mL). Furthermore, the result showed high levels of phenolic content and unexpectedly some higher levels of mineral content in CS. The results suggest that the phenolic rich extracts of CS and CM may have a therapeutic potential against diseases associated with oxidative stress and may be useful in the management of hyperglycemia in diabetic patients. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/28116307/Antioxidant_Activity_and_Inhibitory_Potential_of_Cistus_salviifolius__L___and_Cistus_monspeliensis__L___Aerial_Parts_Extracts_against_Key_Enzymes_Linked_to_Hyperglycemia_ L2 - https://doi.org/10.1155/2017/2789482 DB - PRIME DP - Unbound Medicine ER -