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Molecular Targets of the Phytocannabinoids: A Complex Picture.
Prog Chem Org Nat Prod 2017; 103:103-131PC

Abstract

For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa L., have been used for their medicinal, as well as, their psychotropic effects. These effects are associated with the phytocannabinoids which are oxygen containing C21 aromatic hydrocarbons found in Cannabis sativa L. To date, over 120 phytocannabinoids have been isolated from Cannabis. For many years, it was assumed that the beneficial effects of the phytocannabinoids were mediated by the cannabinoid receptors, CB1 and CB2. However, today we know that the picture is much more complex, with the same phytocannabinoid acting at multiple targets. This contribution focuses on the molecular pharmacology of the phytocannabinoids, including Δ9-THC and CBD, from the prospective of the targets at which these important compounds act.

Authors+Show Affiliations

Chemistry and Biochemistry Department, UNC Greensboro, 1400 Spring Garden Street, Greensboro, NC, 27412, USA.Chemistry and Biochemistry Department, UNC Greensboro, 1400 Spring Garden Street, Greensboro, NC, 27412, USA.Chemistry and Biochemistry Department, UNC Greensboro, 1400 Spring Garden Street, Greensboro, NC, 27412, USA. phreggio@uncg.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28120232

Citation

Morales, Paula, et al. "Molecular Targets of the Phytocannabinoids: a Complex Picture." Progress in the Chemistry of Organic Natural Products, vol. 103, 2017, pp. 103-131.
Morales P, Hurst DP, Reggio PH. Molecular Targets of the Phytocannabinoids: A Complex Picture. Prog Chem Org Nat Prod. 2017;103:103-131.
Morales, P., Hurst, D. P., & Reggio, P. H. (2017). Molecular Targets of the Phytocannabinoids: A Complex Picture. Progress in the Chemistry of Organic Natural Products, 103, pp. 103-131. doi:10.1007/978-3-319-45541-9_4.
Morales P, Hurst DP, Reggio PH. Molecular Targets of the Phytocannabinoids: a Complex Picture. Prog Chem Org Nat Prod. 2017;103:103-131. PubMed PMID: 28120232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular Targets of the Phytocannabinoids: A Complex Picture. AU - Morales,Paula, AU - Hurst,Dow P, AU - Reggio,Patricia H, PY - 2017/1/26/entrez PY - 2017/1/26/pubmed PY - 2017/6/7/medline KW - CB1 receptor KW - CB2 receptor KW - CBC KW - CBD KW - CBDV KW - CBE KW - CBG KW - CBL KW - CBN KW - CBND KW - CBT KW - CBV KW - GPCR KW - Glycine receptor KW - PPARγ KW - Phytocannabinoid KW - THCV KW - TRPA1 channel KW - TRPM8 channel KW - TRPV1 channel KW - Δ8-THC KW - Δ9-THC SP - 103 EP - 131 JF - Progress in the chemistry of organic natural products JO - Prog Chem Org Nat Prod VL - 103 N2 - For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa L., have been used for their medicinal, as well as, their psychotropic effects. These effects are associated with the phytocannabinoids which are oxygen containing C21 aromatic hydrocarbons found in Cannabis sativa L. To date, over 120 phytocannabinoids have been isolated from Cannabis. For many years, it was assumed that the beneficial effects of the phytocannabinoids were mediated by the cannabinoid receptors, CB1 and CB2. However, today we know that the picture is much more complex, with the same phytocannabinoid acting at multiple targets. This contribution focuses on the molecular pharmacology of the phytocannabinoids, including Δ9-THC and CBD, from the prospective of the targets at which these important compounds act. SN - 2191-7043 UR - https://www.unboundmedicine.com/medline/citation/28120232/Molecular_Targets_of_the_Phytocannabinoids:_A_Complex_Picture_ L2 - https://dx.doi.org/10.1007/978-3-319-45541-9_4 DB - PRIME DP - Unbound Medicine ER -