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Scanning from an independently specified branch point defines the 3' splice site of mammalian introns.
Nature. 1989 Nov 16; 342(6247):243-7.Nat

Abstract

During pre-messenger RNA splicing the lariat branch point in mammalian introns is specified independently of the 3' splice site by the sequence surrounding the branch point and by an adjacent downstream polypyrimidine tract. The 3' splice site is dispensable for spliceosome assembly and cleavage at the 5' splice site, and is itself determined by a scanning process that recognizes the first AG located 3' of the branch point/polypyrimidine tract, irrespective of distance or sequence environment.

Authors+Show Affiliations

Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, Boston, Massachusetts.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2812024

Citation

Smith, C W., et al. "Scanning From an Independently Specified Branch Point Defines the 3' Splice Site of Mammalian Introns." Nature, vol. 342, no. 6247, 1989, pp. 243-7.
Smith CW, Porro EB, Patton JG, et al. Scanning from an independently specified branch point defines the 3' splice site of mammalian introns. Nature. 1989;342(6247):243-7.
Smith, C. W., Porro, E. B., Patton, J. G., & Nadal-Ginard, B. (1989). Scanning from an independently specified branch point defines the 3' splice site of mammalian introns. Nature, 342(6247), 243-7.
Smith CW, et al. Scanning From an Independently Specified Branch Point Defines the 3' Splice Site of Mammalian Introns. Nature. 1989 Nov 16;342(6247):243-7. PubMed PMID: 2812024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scanning from an independently specified branch point defines the 3' splice site of mammalian introns. AU - Smith,C W, AU - Porro,E B, AU - Patton,J G, AU - Nadal-Ginard,B, PY - 1989/11/16/pubmed PY - 1989/11/16/medline PY - 1989/11/16/entrez SP - 243 EP - 7 JF - Nature JO - Nature VL - 342 IS - 6247 N2 - During pre-messenger RNA splicing the lariat branch point in mammalian introns is specified independently of the 3' splice site by the sequence surrounding the branch point and by an adjacent downstream polypyrimidine tract. The 3' splice site is dispensable for spliceosome assembly and cleavage at the 5' splice site, and is itself determined by a scanning process that recognizes the first AG located 3' of the branch point/polypyrimidine tract, irrespective of distance or sequence environment. SN - 0028-0836 UR - https://www.unboundmedicine.com/medline/citation/2812024/Scanning_from_an_independently_specified_branch_point_defines_the_3'_splice_site_of_mammalian_introns_ L2 - https://doi.org/10.1038/342243a0 DB - PRIME DP - Unbound Medicine ER -