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miRNAs as biomarkers of neurodegenerative disorders.
Biomark Med. 2017 Feb; 11(2):151-167.BM

Abstract

Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons, ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing therapies are mainly aimed at treating the most bothersome symptoms. Since early treatment is crucial in NDDs, there is an urgent need for specific and sensitive biomarkers that can aid in early diagnosis of these disorders. Recently, altered expression of miRNAs has been implicated in several neurological disorders, including NDDs. miRNA expression has been extensively investigated in the cells, tissues and body fluids of patients with different types of NDDs. The aim of this review is to provide a comprehensive overview of miRNAs as biomarkers and therapeutic targets for NDDs.

Authors+Show Affiliations

Department of Neurogenetics, Institute for Communicative & Cognitive Neurosciences (ICCONS), Shoranur, Palakkad 679 523, Kerala, India.Department of Neurogenetics, Institute for Communicative & Cognitive Neurosciences (ICCONS), Shoranur, Palakkad 679 523, Kerala, India.Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan.Department of Neurology, Institute for Communicative & Cognitive Neurosciences (ICCONS), Shoranur, Palakkad 679 523, Kerala, India.Department of Neurogenetics, Institute for Communicative & Cognitive Neurosciences (ICCONS), Shoranur, Palakkad 679 523, Kerala, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28125293

Citation

Viswambharan, Vijitha, et al. "MiRNAs as Biomarkers of Neurodegenerative Disorders." Biomarkers in Medicine, vol. 11, no. 2, 2017, pp. 151-167.
Viswambharan V, Thanseem I, Vasu MM, et al. MiRNAs as biomarkers of neurodegenerative disorders. Biomark Med. 2017;11(2):151-167.
Viswambharan, V., Thanseem, I., Vasu, M. M., Poovathinal, S. A., & Anitha, A. (2017). MiRNAs as biomarkers of neurodegenerative disorders. Biomarkers in Medicine, 11(2), 151-167. https://doi.org/10.2217/bmm-2016-0242
Viswambharan V, et al. MiRNAs as Biomarkers of Neurodegenerative Disorders. Biomark Med. 2017;11(2):151-167. PubMed PMID: 28125293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - miRNAs as biomarkers of neurodegenerative disorders. AU - Viswambharan,Vijitha, AU - Thanseem,Ismail, AU - Vasu,Mahesh M, AU - Poovathinal,Suresh A, AU - Anitha,Ayyappan, Y1 - 2017/01/26/ PY - 2017/1/27/pubmed PY - 2017/10/27/medline PY - 2017/1/27/entrez KW - Alzheimer's disease KW - Friedreich's ataxia KW - Huntington's disease KW - Parkinson's disease KW - amyotrophic lateral sclerosis KW - miRNA KW - multiple sclerosis KW - prion disease KW - spinal muscular atrophy KW - spinocerebellar ataxia SP - 151 EP - 167 JF - Biomarkers in medicine JO - Biomark Med VL - 11 IS - 2 N2 - Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons, ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing therapies are mainly aimed at treating the most bothersome symptoms. Since early treatment is crucial in NDDs, there is an urgent need for specific and sensitive biomarkers that can aid in early diagnosis of these disorders. Recently, altered expression of miRNAs has been implicated in several neurological disorders, including NDDs. miRNA expression has been extensively investigated in the cells, tissues and body fluids of patients with different types of NDDs. The aim of this review is to provide a comprehensive overview of miRNAs as biomarkers and therapeutic targets for NDDs. SN - 1752-0371 UR - https://www.unboundmedicine.com/medline/citation/28125293/miRNAs_as_biomarkers_of_neurodegenerative_disorders_ L2 - http://www.futuremedicine.com/doi/full/10.2217/bmm-2016-0242?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -