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Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis.
PLoS One. 2017; 12(1):e0170172.Plos

Abstract

BACKGROUND/OBJECTIVE

Chronic inflammation contributes to the onset and development of metabolic diseases. Clinical evidence has suggested that coenzyme Q10 (CoQ10) has some effects on inflammatory markers. However, these results are equivocal. The aim of this systematic review was to assess the effects of CoQ10 on serum levels of inflammatory markers in people with metabolic diseases.

METHODS

Electronic databases were searched up to February 2016 for randomized controlled trials (RCTs). The outcome parameters were related to inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and C reactive protein (CRP). RevMan software was used for meta-analysis. Meta-regression analysis, Egger line regression test and Begg rank correlation test were performed by STATA software.

RESULTS

Nine trials involving 428 subjects were included in this meta-analysis. The results showed that compared with control group, CoQ10 supplementation has significantly improved the serum level of CoQ10 by 1.17μg/ml [MD = 1.17, 95% CI (0.47 to 1.87) μg/ml, I2 = 94%]. Meanwhile, it has significantly decreased TNF-α by 0.45 pg/ml [MD = -0.45, 95% CI (-0.67 to -0.24) pg/ml, I2 = 0%]. No significant difference was observed between CoQ10 and placebo with regard to CRP [MD = -0.21, 95% CI (-0.60 to 0.17) mg/L, I2 = 21%] and IL-6 [MD = -0.89, 95% CI (-1.95 to 0.16) pg/ml, I2 = 84%].

CONCLUSIONS

CoQ10 supplementation may partly improve the process of inflammatory state. The effects of CoQ10 on inflammation should be further investigated by conducting larger sample size and well-defined trials of long enough duration.

Authors+Show Affiliations

Department of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University. Chengdu, China.Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.Department of Surgery, Shanghai Ninth People's Hospital (North), Shanghai Jiaotong University School of Medicine, Shanghai, China.The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.Department of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University. Chengdu, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

28125601

Citation

Zhai, Junya, et al. "Effects of Coenzyme Q10 On Markers of Inflammation: a Systematic Review and Meta-Analysis." PloS One, vol. 12, no. 1, 2017, pp. e0170172.
Zhai J, Bo Y, Lu Y, et al. Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis. PLoS One. 2017;12(1):e0170172.
Zhai, J., Bo, Y., Lu, Y., Liu, C., & Zhang, L. (2017). Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis. PloS One, 12(1), e0170172. https://doi.org/10.1371/journal.pone.0170172
Zhai J, et al. Effects of Coenzyme Q10 On Markers of Inflammation: a Systematic Review and Meta-Analysis. PLoS One. 2017;12(1):e0170172. PubMed PMID: 28125601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis. AU - Zhai,Junya, AU - Bo,Yacong, AU - Lu,Yan, AU - Liu,Chunli, AU - Zhang,Lishi, Y1 - 2017/01/26/ PY - 2016/04/20/received PY - 2016/12/30/accepted PY - 2017/1/27/entrez PY - 2017/1/27/pubmed PY - 2017/8/10/medline SP - e0170172 EP - e0170172 JF - PloS one JO - PLoS One VL - 12 IS - 1 N2 - BACKGROUND/OBJECTIVE: Chronic inflammation contributes to the onset and development of metabolic diseases. Clinical evidence has suggested that coenzyme Q10 (CoQ10) has some effects on inflammatory markers. However, these results are equivocal. The aim of this systematic review was to assess the effects of CoQ10 on serum levels of inflammatory markers in people with metabolic diseases. METHODS: Electronic databases were searched up to February 2016 for randomized controlled trials (RCTs). The outcome parameters were related to inflammatory factors, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and C reactive protein (CRP). RevMan software was used for meta-analysis. Meta-regression analysis, Egger line regression test and Begg rank correlation test were performed by STATA software. RESULTS: Nine trials involving 428 subjects were included in this meta-analysis. The results showed that compared with control group, CoQ10 supplementation has significantly improved the serum level of CoQ10 by 1.17μg/ml [MD = 1.17, 95% CI (0.47 to 1.87) μg/ml, I2 = 94%]. Meanwhile, it has significantly decreased TNF-α by 0.45 pg/ml [MD = -0.45, 95% CI (-0.67 to -0.24) pg/ml, I2 = 0%]. No significant difference was observed between CoQ10 and placebo with regard to CRP [MD = -0.21, 95% CI (-0.60 to 0.17) mg/L, I2 = 21%] and IL-6 [MD = -0.89, 95% CI (-1.95 to 0.16) pg/ml, I2 = 84%]. CONCLUSIONS: CoQ10 supplementation may partly improve the process of inflammatory state. The effects of CoQ10 on inflammation should be further investigated by conducting larger sample size and well-defined trials of long enough duration. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/28125601/Effects_of_Coenzyme_Q10_on_Markers_of_Inflammation:_A_Systematic_Review_and_Meta_Analysis_ DB - PRIME DP - Unbound Medicine ER -