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Retinal Nerve Fiber Layer May Be Better Preserved in MOG-IgG versus AQP4-IgG Optic Neuritis: A Cohort Study.
PLoS One. 2017; 12(1):e0170847.Plos

Abstract

BACKGROUND

Optic neuritis (ON) in patients with anti-myelin oligodendrocyte glycoprotein (MOG)-IgG antibodies has been associated with a better clinical outcome than anti-aquaporin 4 (AQP4)- IgG ON. Average retinal nerve fiber layer thickness (RNFL) correlates with visual outcome after ON.

OBJECTIVES

The aim of this study was to examine whether anti-MOG-IgG ON is associated with better average RNFL compared to anti-AQP4-IgG ON, and whether this corresponds with a better visual outcome.

METHODS

A retrospective study was done in a consecutive cohort of patients following anti-AQP4-IgG and anti-MOG-IgG ON. A generalized estimating equation (GEE) models analysis was used to compare average RNFL outcomes in ON eyes of patients with MOG-IgG to AQP4-IgG-positive patients, after adjusting for the number of ON events. The final mean visual field defect and visual acuity were compared between ON eyes of MOG-IgG and AQP4-IgG-positive patients. A correlation between average RNFL and visual function was performed in all study eyes.

RESULTS

Sixteen patients were analyzed; ten AQP4-IgG-positive and six MOG-IgG-positive. The six patients with MOG-IgG had ten ON events with disc edema, five of which were bilateral. In the AQP4-IgG-positive ON events, 1/10 patients had disc edema. Final average RNFL was significantly better in eyes following MOG-IgG-ON (75.33μm), compared to 63.63μm in AQP4-IgG-ON, after adjusting for the number of ON attacks (GEE, p = 0.023). Mean visual field defects were significantly smaller (GEE, p = 0.046) among MOG-IgG positive ON eyes compared to AQP-IgG positive ON eyes, but last visual acuity did not differ between the groups (GEE, p = 0.153). Among all eyes, average RNFL positively correlated with mean visual field defect (GEE, p = 0.00015) and negatively correlated with final visual acuity (GEE, p = 0.00005).

CONCLUSIONS

Following ON, RNFL is better preserved in eyes of patients with MOG-IgG antibodies compared to those with AQP4-IgG antibodies, correlating with better visual outcomes.

Authors+Show Affiliations

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Neuro-Ophthalmology Unit, Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel.Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Neuro-Immunology Service and Department of Neurology, Rabin Medical Center, Petah Tikva, Israel.Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Neuro-Ophthalmology Unit, Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel.Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Department of Epidemiology and Preventive Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Neuro-Ophthalmology Unit, Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel.Service de Neurologie A, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron, France.Eye Center, Medical Center, University of Freiburg, Germany, and Faculty of Medicine, University of Freiburg, Germany.Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Neuro-Immunology Service and Department of Neurology, Rabin Medical Center, Petah Tikva, Israel.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28125740

Citation

Stiebel-Kalish, Hadas, et al. "Retinal Nerve Fiber Layer May Be Better Preserved in MOG-IgG Versus AQP4-IgG Optic Neuritis: a Cohort Study." PloS One, vol. 12, no. 1, 2017, pp. e0170847.
Stiebel-Kalish H, Lotan I, Brody J, et al. Retinal Nerve Fiber Layer May Be Better Preserved in MOG-IgG versus AQP4-IgG Optic Neuritis: A Cohort Study. PLoS ONE. 2017;12(1):e0170847.
Stiebel-Kalish, H., Lotan, I., Brody, J., Chodick, G., Bialer, O., Marignier, R., Bach, M., & Hellmann, M. A. (2017). Retinal Nerve Fiber Layer May Be Better Preserved in MOG-IgG versus AQP4-IgG Optic Neuritis: A Cohort Study. PloS One, 12(1), e0170847. https://doi.org/10.1371/journal.pone.0170847
Stiebel-Kalish H, et al. Retinal Nerve Fiber Layer May Be Better Preserved in MOG-IgG Versus AQP4-IgG Optic Neuritis: a Cohort Study. PLoS ONE. 2017;12(1):e0170847. PubMed PMID: 28125740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal Nerve Fiber Layer May Be Better Preserved in MOG-IgG versus AQP4-IgG Optic Neuritis: A Cohort Study. AU - Stiebel-Kalish,Hadas, AU - Lotan,Itay, AU - Brody,Judith, AU - Chodick,Gabriel, AU - Bialer,Omer, AU - Marignier,Romain, AU - Bach,Michael, AU - Hellmann,Mark Andrew, Y1 - 2017/01/26/ PY - 2016/08/25/received PY - 2017/01/11/accepted PY - 2017/1/27/entrez PY - 2017/1/27/pubmed PY - 2017/8/11/medline SP - e0170847 EP - e0170847 JF - PloS one JO - PLoS ONE VL - 12 IS - 1 N2 - BACKGROUND: Optic neuritis (ON) in patients with anti-myelin oligodendrocyte glycoprotein (MOG)-IgG antibodies has been associated with a better clinical outcome than anti-aquaporin 4 (AQP4)- IgG ON. Average retinal nerve fiber layer thickness (RNFL) correlates with visual outcome after ON. OBJECTIVES: The aim of this study was to examine whether anti-MOG-IgG ON is associated with better average RNFL compared to anti-AQP4-IgG ON, and whether this corresponds with a better visual outcome. METHODS: A retrospective study was done in a consecutive cohort of patients following anti-AQP4-IgG and anti-MOG-IgG ON. A generalized estimating equation (GEE) models analysis was used to compare average RNFL outcomes in ON eyes of patients with MOG-IgG to AQP4-IgG-positive patients, after adjusting for the number of ON events. The final mean visual field defect and visual acuity were compared between ON eyes of MOG-IgG and AQP4-IgG-positive patients. A correlation between average RNFL and visual function was performed in all study eyes. RESULTS: Sixteen patients were analyzed; ten AQP4-IgG-positive and six MOG-IgG-positive. The six patients with MOG-IgG had ten ON events with disc edema, five of which were bilateral. In the AQP4-IgG-positive ON events, 1/10 patients had disc edema. Final average RNFL was significantly better in eyes following MOG-IgG-ON (75.33μm), compared to 63.63μm in AQP4-IgG-ON, after adjusting for the number of ON attacks (GEE, p = 0.023). Mean visual field defects were significantly smaller (GEE, p = 0.046) among MOG-IgG positive ON eyes compared to AQP-IgG positive ON eyes, but last visual acuity did not differ between the groups (GEE, p = 0.153). Among all eyes, average RNFL positively correlated with mean visual field defect (GEE, p = 0.00015) and negatively correlated with final visual acuity (GEE, p = 0.00005). CONCLUSIONS: Following ON, RNFL is better preserved in eyes of patients with MOG-IgG antibodies compared to those with AQP4-IgG antibodies, correlating with better visual outcomes. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/28125740/Retinal_Nerve_Fiber_Layer_May_Be_Better_Preserved_in_MOG_IgG_versus_AQP4_IgG_Optic_Neuritis:_A_Cohort_Study_ L2 - http://dx.plos.org/10.1371/journal.pone.0170847 DB - PRIME DP - Unbound Medicine ER -