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Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis.
World J Gastroenterol. 2017 Jan 14; 23(2):336-344.WJ

Abstract

AIM

To confirm previous conclusions on Saccharomyces cerevisiae (S. cerevisiae) CNCM I-3856 for irritable bowel syndrome (IBS) management.

METHODS

An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal (GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve (AUC) and weekly means], responder status, and bowel movements (stool frequency and consistency). Statistical analyses were conducted in Intent to Treat (ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline ("IBS-C ≥ 2 subpopulation").

RESULTS

S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC (W5-W8)] with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group (P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group (P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit (a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder (reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group (P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as "normal" compared to Placebo (respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation (Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).

CONCLUSION

This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations.

Authors+Show Affiliations

Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

28127207

Citation

Cayzeele-Decherf, Amélie, et al. "Saccharomyces Cerevisiae CNCM I-3856 in Irritable Bowel Syndrome: an Individual Subject Meta-analysis." World Journal of Gastroenterology, vol. 23, no. 2, 2017, pp. 336-344.
Cayzeele-Decherf A, Pélerin F, Leuillet S, et al. Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis. World J Gastroenterol. 2017;23(2):336-344.
Cayzeele-Decherf, A., Pélerin, F., Leuillet, S., Douillard, B., Housez, B., Cazaubiel, M., Jacobson, G. K., Jüsten, P., & Desreumaux, P. (2017). Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis. World Journal of Gastroenterology, 23(2), 336-344. https://doi.org/10.3748/wjg.v23.i2.336
Cayzeele-Decherf A, et al. Saccharomyces Cerevisiae CNCM I-3856 in Irritable Bowel Syndrome: an Individual Subject Meta-analysis. World J Gastroenterol. 2017 Jan 14;23(2):336-344. PubMed PMID: 28127207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis. AU - Cayzeele-Decherf,Amélie, AU - Pélerin,Fanny, AU - Leuillet,Sébastien, AU - Douillard,Benoit, AU - Housez,Béatrice, AU - Cazaubiel,Murielle, AU - Jacobson,Gunnard K, AU - Jüsten,Peter, AU - Desreumaux,Pierre, PY - 2016/08/02/received PY - 2016/10/03/revised PY - 2016/10/19/accepted PY - 2017/1/28/entrez PY - 2017/1/28/pubmed PY - 2017/7/18/medline KW - Abdominal pain KW - Constipation KW - Irritable bowel syndrome KW - Probiotics KW - Saccharomyces cerevisiae SP - 336 EP - 344 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 23 IS - 2 N2 - AIM: To confirm previous conclusions on Saccharomyces cerevisiae (S. cerevisiae) CNCM I-3856 for irritable bowel syndrome (IBS) management. METHODS: An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal (GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve (AUC) and weekly means], responder status, and bowel movements (stool frequency and consistency). Statistical analyses were conducted in Intent to Treat (ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline ("IBS-C ≥ 2 subpopulation"). RESULTS: S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC (W5-W8)] with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group (P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group (P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit (a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder (reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group (P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as "normal" compared to Placebo (respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation (Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009). CONCLUSION: This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/28127207/Saccharomyces_cerevisiae_CNCM_I_3856_in_irritable_bowel_syndrome:_An_individual_subject_meta_analysis_ L2 - https://www.wjgnet.com/1007-9327/full/v23/i2/336.htm DB - PRIME DP - Unbound Medicine ER -