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Piceatannol extends the lifespan of Caenorhabditis elegans via DAF-16.
Biofactors. 2017 May 06; 43(3):379-387.B

Abstract

Piceatannol is a natural stilbene with many beneficial effects, such as antioxidative, anti-inflammatory, antiatherogenic activities; however, its role on aging is not known. In this study, we used Caenorhabditis elegans as an animal model to study the effect of piceatannol on its lifespan and investigated the underlying mechanisms. The results showed that 50 and 100 µM piceatannol significantly extended the lifespan of C. elegans without altering the growth rate, worm size and progeny production. Piceatannol delayed the age-related decline of pumping rate and locomotive activity, and protected the worms from heat and oxidative stress. This study further indicated that lifespan extension and enhanced stress resistance induced by piceatannol requires DAF-16. Since DAF-16 is conserved from nematodes to mammals, our study may have important implications in utilizing piceatannol to promote healthy aging and combat age-related disease in humans. © 2016 BioFactors, 43(3):379-387, 2017.

Authors+Show Affiliations

Department of Food Science, University of Massachusetts, Amherst, MA, USA.Department of Food Science, University of Massachusetts, Amherst, MA, USA.Department of Food Science, University of Massachusetts, Amherst, MA, USA.Bow High School, Bow, NH, USA.Department of Food Science, Purdue University, West Lafayette, IN, USA. Center for Cancer Research Purdue University, West Lafayette, IN, USA.Department of Food Science, University of Massachusetts, Amherst, MA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28128482

Citation

Shen, Peiyi, et al. "Piceatannol Extends the Lifespan of Caenorhabditis Elegans Via DAF-16." BioFactors (Oxford, England), vol. 43, no. 3, 2017, pp. 379-387.
Shen P, Yue Y, Sun Q, et al. Piceatannol extends the lifespan of Caenorhabditis elegans via DAF-16. Biofactors. 2017;43(3):379-387.
Shen, P., Yue, Y., Sun, Q., Kasireddy, N., Kim, K. H., & Park, Y. (2017). Piceatannol extends the lifespan of Caenorhabditis elegans via DAF-16. BioFactors (Oxford, England), 43(3), 379-387. https://doi.org/10.1002/biof.1346
Shen P, et al. Piceatannol Extends the Lifespan of Caenorhabditis Elegans Via DAF-16. Biofactors. 2017 May 6;43(3):379-387. PubMed PMID: 28128482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Piceatannol extends the lifespan of Caenorhabditis elegans via DAF-16. AU - Shen,Peiyi, AU - Yue,Yiren, AU - Sun,Quancai, AU - Kasireddy,Nandita, AU - Kim,Kee-Hong, AU - Park,Yeonhwa, Y1 - 2017/01/27/ PY - 2016/10/03/received PY - 2016/11/17/accepted PY - 2017/1/28/pubmed PY - 2018/3/15/medline PY - 2017/1/28/entrez KW - C. elegans KW - daf-16 KW - lifespan KW - piceatannol SP - 379 EP - 387 JF - BioFactors (Oxford, England) JO - Biofactors VL - 43 IS - 3 N2 - Piceatannol is a natural stilbene with many beneficial effects, such as antioxidative, anti-inflammatory, antiatherogenic activities; however, its role on aging is not known. In this study, we used Caenorhabditis elegans as an animal model to study the effect of piceatannol on its lifespan and investigated the underlying mechanisms. The results showed that 50 and 100 µM piceatannol significantly extended the lifespan of C. elegans without altering the growth rate, worm size and progeny production. Piceatannol delayed the age-related decline of pumping rate and locomotive activity, and protected the worms from heat and oxidative stress. This study further indicated that lifespan extension and enhanced stress resistance induced by piceatannol requires DAF-16. Since DAF-16 is conserved from nematodes to mammals, our study may have important implications in utilizing piceatannol to promote healthy aging and combat age-related disease in humans. © 2016 BioFactors, 43(3):379-387, 2017. SN - 1872-8081 UR - https://www.unboundmedicine.com/medline/citation/28128482/Piceatannol_extends_the_lifespan_of_Caenorhabditis_elegans_via_DAF_16_ L2 - https://doi.org/10.1002/biof.1346 DB - PRIME DP - Unbound Medicine ER -